Joint Associations Between Body Mass Index and Waist Circumference With Atrial Fibrillation in Men and Women
Background Associations between adiposity and atrial fibrillation (AF) might differ between sexes. We aimed to determine precise estimates of the risk of AF by body mass index (BMI) and waist circumference (WC) in men and women. Methods and Results Between 2008 and 2013, over 3.2 million adults atte...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-04-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.120.019025 |
| _version_ | 1811334020437377024 |
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| author | Michiel H. F. Poorthuis Paul Sherliker Gert J. de Borst Jennifer L. Carter Kin Bong Hubert Lam Nicholas R. Jones Alison Halliday Sarah Lewington Richard Bulbulia |
| author_facet | Michiel H. F. Poorthuis Paul Sherliker Gert J. de Borst Jennifer L. Carter Kin Bong Hubert Lam Nicholas R. Jones Alison Halliday Sarah Lewington Richard Bulbulia |
| author_sort | Michiel H. F. Poorthuis |
| collection | DOAJ |
| description | Background Associations between adiposity and atrial fibrillation (AF) might differ between sexes. We aimed to determine precise estimates of the risk of AF by body mass index (BMI) and waist circumference (WC) in men and women. Methods and Results Between 2008 and 2013, over 3.2 million adults attended commercial screening clinics. Participants completed health questionnaires and underwent physical examination along with cardiovascular investigations, including an ECG. We excluded those with cardiovascular and cardiac disease. We used multivariable logistic regression and determined joint associations of BMI and WC and the risk of AF in men and women by comparing likelihood ratio χ2 statistics. Among 2.1 million included participants 12 067 (0.6%) had AF. A positive association between BMI per 5 kg/m2 increment and AF was observed, with an odds ratio of 1.65 (95% CI, 1.57–1.73) for men and 1.36 (95% CI, 1.30–1.42) for women among those with a BMI above 20 kg/m2. We found a positive association between AF and WC per 10 cm increment, with an odds ratio of 1.47 (95% CI, 1.36–1.60) for men and 1.37 (95% CI, 1.26–1.49) for women. Improvement of likelihood ratio χ2 was equal after adding BMI and WC to models with all participants. In men, WC showed stronger improvement of likelihood ratio χ2 than BMI (30% versus 23%). In women, BMI showed stronger improvement of likelihood ratio χ2 than WC (23% versus 12%). Conclusions We found a positive association between BMI (above 20 kg/m2) and AF and between WC and AF in both men and women. BMI seems a more informative measure about risk of AF in women and WC seems more informative in men. |
| first_indexed | 2024-04-13T17:01:33Z |
| format | Article |
| id | doaj.art-9b8ec0339aa9442cbd0a5e7d56175652 |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-04-13T17:01:33Z |
| publishDate | 2021-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-9b8ec0339aa9442cbd0a5e7d561756522022-12-22T02:38:38ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802021-04-0110810.1161/JAHA.120.019025Joint Associations Between Body Mass Index and Waist Circumference With Atrial Fibrillation in Men and WomenMichiel H. F. Poorthuis0Paul Sherliker1Gert J. de Borst2Jennifer L. Carter3Kin Bong Hubert Lam4Nicholas R. Jones5Alison Halliday6Sarah Lewington7Richard Bulbulia8Clinical Trial Service Unit and Epidemiological Studies Unit Nuffield Department of Population Health University of Oxford United KingdomClinical Trial Service Unit and Epidemiological Studies Unit Nuffield Department of Population Health University of Oxford United KingdomDepartment of Vascular Surgery University Medical Center Utrecht Utrecht The NetherlandsClinical Trial Service Unit and Epidemiological Studies Unit Nuffield Department of Population Health University of Oxford United KingdomClinical Trial Service Unit and Epidemiological Studies Unit Nuffield Department of Population Health University of Oxford United KingdomNuffield Department of Primary Care Health Sciences University of Oxford Oxford United KingdomNuffield Department of Surgical Sciences University of Oxford Oxford United KingdomClinical Trial Service Unit and Epidemiological Studies Unit Nuffield Department of Population Health University of Oxford United KingdomClinical Trial Service Unit and Epidemiological Studies Unit Nuffield Department of Population Health University of Oxford United KingdomBackground Associations between adiposity and atrial fibrillation (AF) might differ between sexes. We aimed to determine precise estimates of the risk of AF by body mass index (BMI) and waist circumference (WC) in men and women. Methods and Results Between 2008 and 2013, over 3.2 million adults attended commercial screening clinics. Participants completed health questionnaires and underwent physical examination along with cardiovascular investigations, including an ECG. We excluded those with cardiovascular and cardiac disease. We used multivariable logistic regression and determined joint associations of BMI and WC and the risk of AF in men and women by comparing likelihood ratio χ2 statistics. Among 2.1 million included participants 12 067 (0.6%) had AF. A positive association between BMI per 5 kg/m2 increment and AF was observed, with an odds ratio of 1.65 (95% CI, 1.57–1.73) for men and 1.36 (95% CI, 1.30–1.42) for women among those with a BMI above 20 kg/m2. We found a positive association between AF and WC per 10 cm increment, with an odds ratio of 1.47 (95% CI, 1.36–1.60) for men and 1.37 (95% CI, 1.26–1.49) for women. Improvement of likelihood ratio χ2 was equal after adding BMI and WC to models with all participants. In men, WC showed stronger improvement of likelihood ratio χ2 than BMI (30% versus 23%). In women, BMI showed stronger improvement of likelihood ratio χ2 than WC (23% versus 12%). Conclusions We found a positive association between BMI (above 20 kg/m2) and AF and between WC and AF in both men and women. BMI seems a more informative measure about risk of AF in women and WC seems more informative in men.https://www.ahajournals.org/doi/10.1161/JAHA.120.019025adiposityatrial fibrillationbody mass indexsex‐specific risk factorswaist circumference |
| spellingShingle | Michiel H. F. Poorthuis Paul Sherliker Gert J. de Borst Jennifer L. Carter Kin Bong Hubert Lam Nicholas R. Jones Alison Halliday Sarah Lewington Richard Bulbulia Joint Associations Between Body Mass Index and Waist Circumference With Atrial Fibrillation in Men and Women Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease adiposity atrial fibrillation body mass index sex‐specific risk factors waist circumference |
| title | Joint Associations Between Body Mass Index and Waist Circumference With Atrial Fibrillation in Men and Women |
| title_full | Joint Associations Between Body Mass Index and Waist Circumference With Atrial Fibrillation in Men and Women |
| title_fullStr | Joint Associations Between Body Mass Index and Waist Circumference With Atrial Fibrillation in Men and Women |
| title_full_unstemmed | Joint Associations Between Body Mass Index and Waist Circumference With Atrial Fibrillation in Men and Women |
| title_short | Joint Associations Between Body Mass Index and Waist Circumference With Atrial Fibrillation in Men and Women |
| title_sort | joint associations between body mass index and waist circumference with atrial fibrillation in men and women |
| topic | adiposity atrial fibrillation body mass index sex‐specific risk factors waist circumference |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.120.019025 |
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