Intranasal Immunization with a Vaccinia Virus Vaccine Vector Expressing Pre-Fusion Stabilized SARS-CoV-2 Spike Fully Protected Mice against Lethal Challenge with the Heavily Mutated Mouse-Adapted SARS2-N501Y<sub>MA30</sub> Strain of SARS-CoV-2

Intranasal Immunization with a Vaccinia Virus Vaccine Vector Expressing Pre-Fusion Stabilized SARS-CoV-2 Spike Fully Protected Mice against Lethal Challenge with the Heavily Mutated Mouse-Adapted SARS2-N501Y<sub>MA30</sub> Strain of SARS-CoV-2

The Omicron SARS-CoV-2 variant has been designated as a variant of concern because its spike protein is heavily mutated. In particular, the Omicron spike is mutated at five positions (K417, N440, E484, Q493, and N501) that have been associated with escape from neutralizing antibodies induced by eith...

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Bibliographic Details
Main Authors: Karen V. Kibler, Mateusz Szczerba, Douglas Lake, Alexa J. Roeder, Masmudur Rahman, Brenda G. Hogue, Lok-Yin Roy Wong, Stanley Perlman, Yize Li, Bertram L. Jacobs
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Vaccines
Subjects:
vaccine
SARS-CoV-2
replication-competent
Online Access:https://www.mdpi.com/2076-393X/10/8/1172

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