Overview of MMP-13 as a Promising Target for the Treatment of Osteoarthritis
Osteoarthritis (OA) is a common degenerative disease characterized by the destruction of articular cartilage and chronic inflammation of surrounding tissues. Matrix metalloproteinase-13 (MMP-13) is the primary MMP involved in cartilage degradation through its particular ability to cleave type II col...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-02-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/4/1742 |
| _version_ | 1797412176481222656 |
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| author | Qichan Hu Melanie Ecker |
| author_facet | Qichan Hu Melanie Ecker |
| author_sort | Qichan Hu |
| collection | DOAJ |
| description | Osteoarthritis (OA) is a common degenerative disease characterized by the destruction of articular cartilage and chronic inflammation of surrounding tissues. Matrix metalloproteinase-13 (MMP-13) is the primary MMP involved in cartilage degradation through its particular ability to cleave type II collagen. Hence, it is an attractive target for the treatment of OA. However, the detailed molecular mechanisms of OA initiation and progression remain elusive, and, currently, there are no interventions available to restore degraded cartilage. This review fully illustrates the involvement of MMP-13 in the initiation and progression of OA through the regulation of MMP-13 activity at the molecular and epigenetic levels, as well as the strategies that have been employed against MMP-13. The aim of this review is to identify MMP-13 as an attractive target for inhibitor development in the treatment of OA. |
| first_indexed | 2024-03-09T04:58:20Z |
| format | Article |
| id | doaj.art-9b8ed809ec0c4a5d83363d0c501f4f8a |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T04:58:20Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-9b8ed809ec0c4a5d83363d0c501f4f8a2023-12-03T13:02:58ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-02-01224174210.3390/ijms22041742Overview of MMP-13 as a Promising Target for the Treatment of OsteoarthritisQichan Hu0Melanie Ecker1Department of Biomedical Engineering, University of North Texas, Denton, TX 76203, USADepartment of Biomedical Engineering, University of North Texas, Denton, TX 76203, USAOsteoarthritis (OA) is a common degenerative disease characterized by the destruction of articular cartilage and chronic inflammation of surrounding tissues. Matrix metalloproteinase-13 (MMP-13) is the primary MMP involved in cartilage degradation through its particular ability to cleave type II collagen. Hence, it is an attractive target for the treatment of OA. However, the detailed molecular mechanisms of OA initiation and progression remain elusive, and, currently, there are no interventions available to restore degraded cartilage. This review fully illustrates the involvement of MMP-13 in the initiation and progression of OA through the regulation of MMP-13 activity at the molecular and epigenetic levels, as well as the strategies that have been employed against MMP-13. The aim of this review is to identify MMP-13 as an attractive target for inhibitor development in the treatment of OA.https://www.mdpi.com/1422-0067/22/4/1742osteoarthritiscartilagetype II collagenmatrix metalloproteinasesMMP-13regulation |
| spellingShingle | Qichan Hu Melanie Ecker Overview of MMP-13 as a Promising Target for the Treatment of Osteoarthritis International Journal of Molecular Sciences osteoarthritis cartilage type II collagen matrix metalloproteinases MMP-13 regulation |
| title | Overview of MMP-13 as a Promising Target for the Treatment of Osteoarthritis |
| title_full | Overview of MMP-13 as a Promising Target for the Treatment of Osteoarthritis |
| title_fullStr | Overview of MMP-13 as a Promising Target for the Treatment of Osteoarthritis |
| title_full_unstemmed | Overview of MMP-13 as a Promising Target for the Treatment of Osteoarthritis |
| title_short | Overview of MMP-13 as a Promising Target for the Treatment of Osteoarthritis |
| title_sort | overview of mmp 13 as a promising target for the treatment of osteoarthritis |
| topic | osteoarthritis cartilage type II collagen matrix metalloproteinases MMP-13 regulation |
| url | https://www.mdpi.com/1422-0067/22/4/1742 |
| work_keys_str_mv | AT qichanhu overviewofmmp13asapromisingtargetforthetreatmentofosteoarthritis AT melanieecker overviewofmmp13asapromisingtargetforthetreatmentofosteoarthritis |