Endoplasmic reticulum stress associates with the development of intervertebral disc degeneration
Endoplasmic reticulum (ER) is an important player in various intracellular signaling pathways that regulate cellular functions in many diseases. Intervertebral disc degeneration (IDD), an age-related degenerative disease, is one of the main clinical causes of low back pain. Although the pathological...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.1094394/full |
| _version_ | 1828066525465018368 |
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| author | Jishang Huang Qingluo Zhou Qun Ren Liliang Luo Guanglin Ji Tiansheng Zheng |
| author_facet | Jishang Huang Qingluo Zhou Qun Ren Liliang Luo Guanglin Ji Tiansheng Zheng |
| author_sort | Jishang Huang |
| collection | DOAJ |
| description | Endoplasmic reticulum (ER) is an important player in various intracellular signaling pathways that regulate cellular functions in many diseases. Intervertebral disc degeneration (IDD), an age-related degenerative disease, is one of the main clinical causes of low back pain. Although the pathological development of IDD is far from being fully elucidated, many studies have been shown that ER stress (ERS) is involved in IDD development and regulates various processes, such as inflammation, cellular senescence and apoptosis, excessive mechanical loading, metabolic disturbances, oxidative stress, calcium homeostasis imbalance, and extracellular matrix (ECM) dysregulation. This review summarizes the formation of ERS and the potential link between ERS and IDD development. ERS can be a promising new therapeutic target for the clinical management of IDD. |
| first_indexed | 2024-04-10T23:31:59Z |
| format | Article |
| id | doaj.art-9b910fcfa3324ecfa886e619e7e68459 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-10T23:31:59Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-9b910fcfa3324ecfa886e619e7e684592023-01-12T04:57:38ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-01-011310.3389/fendo.2022.10943941094394Endoplasmic reticulum stress associates with the development of intervertebral disc degenerationJishang Huang0Qingluo Zhou1Qun Ren2Liliang Luo3Guanglin Ji4Tiansheng Zheng5Department of Orthopedics, First Affiliated Hospital of Gannan Medical University, Ganzhou, ChinaDepartment of Orthopedics, First Affiliated Hospital of Gannan Medical University, Ganzhou, ChinaCollege of Pharmacy, Gannan Medical University, Ganzhou, ChinaDepartment of Orthopedics, Shangyou Hospital of traditional Chinese Medicine, Ganzhou, ChinaDepartment of Orthopedics, First Affiliated Hospital of Gannan Medical University, Ganzhou, ChinaDepartment of Orthopedics, First Affiliated Hospital of Gannan Medical University, Ganzhou, ChinaEndoplasmic reticulum (ER) is an important player in various intracellular signaling pathways that regulate cellular functions in many diseases. Intervertebral disc degeneration (IDD), an age-related degenerative disease, is one of the main clinical causes of low back pain. Although the pathological development of IDD is far from being fully elucidated, many studies have been shown that ER stress (ERS) is involved in IDD development and regulates various processes, such as inflammation, cellular senescence and apoptosis, excessive mechanical loading, metabolic disturbances, oxidative stress, calcium homeostasis imbalance, and extracellular matrix (ECM) dysregulation. This review summarizes the formation of ERS and the potential link between ERS and IDD development. ERS can be a promising new therapeutic target for the clinical management of IDD.https://www.frontiersin.org/articles/10.3389/fendo.2022.1094394/fullintervertebral disc degenerationendoplasmic reticulum stressapoptosisPERKIRE1αATF6 |
| spellingShingle | Jishang Huang Qingluo Zhou Qun Ren Liliang Luo Guanglin Ji Tiansheng Zheng Endoplasmic reticulum stress associates with the development of intervertebral disc degeneration Frontiers in Endocrinology intervertebral disc degeneration endoplasmic reticulum stress apoptosis PERK IRE1α ATF6 |
| title | Endoplasmic reticulum stress associates with the development of intervertebral disc degeneration |
| title_full | Endoplasmic reticulum stress associates with the development of intervertebral disc degeneration |
| title_fullStr | Endoplasmic reticulum stress associates with the development of intervertebral disc degeneration |
| title_full_unstemmed | Endoplasmic reticulum stress associates with the development of intervertebral disc degeneration |
| title_short | Endoplasmic reticulum stress associates with the development of intervertebral disc degeneration |
| title_sort | endoplasmic reticulum stress associates with the development of intervertebral disc degeneration |
| topic | intervertebral disc degeneration endoplasmic reticulum stress apoptosis PERK IRE1α ATF6 |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.1094394/full |
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