Effects of water fluoridation on early embryonic development of zebrafish
Fluoride has strong electronegativity and exposes diversely in nature. Water fluoridation is the most pervasive form of occurrence, representing a significant threat to human health. In this study, we investigate the morphometric and physiological alterations triggered by fluoride stimulation during...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651323014112 |
| _version_ | 1797350620949118976 |
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| author | Ya-Lan Wei Xin-Chen Lin Ying-Ying Liu Yu-Qing Lei Xu-Dong Zhuang Hai-Tao Zhang Xin-Rui Wang |
| author_facet | Ya-Lan Wei Xin-Chen Lin Ying-Ying Liu Yu-Qing Lei Xu-Dong Zhuang Hai-Tao Zhang Xin-Rui Wang |
| author_sort | Ya-Lan Wei |
| collection | DOAJ |
| description | Fluoride has strong electronegativity and exposes diversely in nature. Water fluoridation is the most pervasive form of occurrence, representing a significant threat to human health. In this study, we investigate the morphometric and physiological alterations triggered by fluoride stimulation during the embryogenesis of zebrafish and reveal its putative effects of stage- and/or dose-dependent. Fluoride exhibits potent biological activity and can be extensively absorbed by the yolk sac, exerting significant effects on the development of multiple organs. This is primarily manifested as restricted nutrient utilization and elevated levels of lipid peroxidation, further leading to the accumulation of superoxide in the yolk sac, liver, and intestines. Moreover, pericardial edema exerts pressure on the brain and eye development, resulting in spinal curvature and reduced body length. Besides, acute fluoride exposure with varying concentrations has led to diverse teratogenic outcomes. A low dose of water fluoridation tends to induce abnormal development of the embryonic yolk sac, while vascular malformation is widely observed in all fluoride-treated groups. The effect of fluoride exposure on blood circulation is universally present, even in zebrafish larvae that do not exhibit obvious deformities. Their swimming behavior is also affected by water fluoridation, resulting in reduced activity and delayed reactions. In conclusion, this study provides valuable insights into the monitoring of environmental quality related to water fluoridation and disease prevention. |
| first_indexed | 2024-03-08T12:47:30Z |
| format | Article |
| id | doaj.art-9b9159a53c3948b8bd2798dd23019e10 |
| institution | Directory Open Access Journal |
| issn | 0147-6513 |
| language | English |
| last_indexed | 2024-03-08T12:47:30Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj.art-9b9159a53c3948b8bd2798dd23019e102024-01-21T05:05:28ZengElsevierEcotoxicology and Environmental Safety0147-65132024-01-01270115907Effects of water fluoridation on early embryonic development of zebrafishYa-Lan Wei0Xin-Chen Lin1Ying-Ying Liu2Yu-Qing Lei3Xu-Dong Zhuang4Hai-Tao Zhang5Xin-Rui Wang6College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian 350122, China; Medical Research Center, Fujian Maternity and Child Health Hospital, Fuzhou, Fujian 350001, ChinaCollege of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian 350122, China; Medical Research Center, Fujian Maternity and Child Health Hospital, Fuzhou, Fujian 350001, ChinaCollege of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian 350122, ChinaCollege of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian 350122, China; Medical Research Center, Fujian Maternity and Child Health Hospital, Fuzhou, Fujian 350001, ChinaCollege of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian 350122, China; Medical Research Center, Fujian Maternity and Child Health Hospital, Fuzhou, Fujian 350001, ChinaCollege of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian 350122, China; Medical Research Center, Fujian Maternity and Child Health Hospital, Fuzhou, Fujian 350001, ChinaCollege of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian 350122, China; Medical Research Center, Fujian Maternity and Child Health Hospital, Fuzhou, Fujian 350001, China; Corresponding author at: Medical Research Center, Fujian Maternity and Child Health Hospital, Fuzhou, Fujian 350001, China.Fluoride has strong electronegativity and exposes diversely in nature. Water fluoridation is the most pervasive form of occurrence, representing a significant threat to human health. In this study, we investigate the morphometric and physiological alterations triggered by fluoride stimulation during the embryogenesis of zebrafish and reveal its putative effects of stage- and/or dose-dependent. Fluoride exhibits potent biological activity and can be extensively absorbed by the yolk sac, exerting significant effects on the development of multiple organs. This is primarily manifested as restricted nutrient utilization and elevated levels of lipid peroxidation, further leading to the accumulation of superoxide in the yolk sac, liver, and intestines. Moreover, pericardial edema exerts pressure on the brain and eye development, resulting in spinal curvature and reduced body length. Besides, acute fluoride exposure with varying concentrations has led to diverse teratogenic outcomes. A low dose of water fluoridation tends to induce abnormal development of the embryonic yolk sac, while vascular malformation is widely observed in all fluoride-treated groups. The effect of fluoride exposure on blood circulation is universally present, even in zebrafish larvae that do not exhibit obvious deformities. Their swimming behavior is also affected by water fluoridation, resulting in reduced activity and delayed reactions. In conclusion, this study provides valuable insights into the monitoring of environmental quality related to water fluoridation and disease prevention.http://www.sciencedirect.com/science/article/pii/S0147651323014112Fluoride toxicityWater fluoridationEmbryogenesisOxidative stressDanio rerio |
| spellingShingle | Ya-Lan Wei Xin-Chen Lin Ying-Ying Liu Yu-Qing Lei Xu-Dong Zhuang Hai-Tao Zhang Xin-Rui Wang Effects of water fluoridation on early embryonic development of zebrafish Ecotoxicology and Environmental Safety Fluoride toxicity Water fluoridation Embryogenesis Oxidative stress Danio rerio |
| title | Effects of water fluoridation on early embryonic development of zebrafish |
| title_full | Effects of water fluoridation on early embryonic development of zebrafish |
| title_fullStr | Effects of water fluoridation on early embryonic development of zebrafish |
| title_full_unstemmed | Effects of water fluoridation on early embryonic development of zebrafish |
| title_short | Effects of water fluoridation on early embryonic development of zebrafish |
| title_sort | effects of water fluoridation on early embryonic development of zebrafish |
| topic | Fluoride toxicity Water fluoridation Embryogenesis Oxidative stress Danio rerio |
| url | http://www.sciencedirect.com/science/article/pii/S0147651323014112 |
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