Understanding the role of inflammation in sensorineural hearing loss: Current goals and future prospects
Abstract Sensorineural hearing loss (SNHL) is a common otologic condition caused by damage to hair cells and spiral ganglion neurons that affects transmission pathways. Most of these cells cannot be regenerated, and there has been no breakthrough in regeneration techniques for inner ear cells. SNHL...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-09-01
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| Series: | Brain-X |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/brx2.34 |
| _version_ | 1797231285206253568 |
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| author | Liling Li Dan Chen Xuexin Lin Jia Luo Jingqian Tan Peng Li |
| author_facet | Liling Li Dan Chen Xuexin Lin Jia Luo Jingqian Tan Peng Li |
| author_sort | Liling Li |
| collection | DOAJ |
| description | Abstract Sensorineural hearing loss (SNHL) is a common otologic condition caused by damage to hair cells and spiral ganglion neurons that affects transmission pathways. Most of these cells cannot be regenerated, and there has been no breakthrough in regeneration techniques for inner ear cells. SNHL has a high incidence rate and can cause a variety of clinical symptoms, greatly impacting people's daily lives. With limited clinical treatments, the search for critical targets is urgent. Studies have shown that inflammation is prevalent in the pathogenesis of SNHL and plays a significant role in it. Inflammation is a normal body defense response, and a systemic anti‐inflammatory approach is undesirable. It is crucial for us to identify potential targets of inflammation in SNHL and take measures specifically targeting those targets with minimal systemic impact. This paper firstly describes the role of inflammation in various types of SNHL and then provides an overview of the interactions between inflammation and cochlear immunity, cochlear microcirculation, vascular spasm, and glutamate metabolism and finally comprehensively examines the feasibility of targets in these interactions. This paper is expected to facilitate the development of targeted anti‐inflammation for SNHL and provide strategies and approaches for treating clinical SNHL. |
| first_indexed | 2024-04-24T15:41:57Z |
| format | Article |
| id | doaj.art-9b919599b4a348219a21268ced451310 |
| institution | Directory Open Access Journal |
| issn | 2835-3153 |
| language | English |
| last_indexed | 2024-04-24T15:41:57Z |
| publishDate | 2023-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Brain-X |
| spelling | doaj.art-9b919599b4a348219a21268ced4513102024-04-01T19:00:07ZengWileyBrain-X2835-31532023-09-0113n/an/a10.1002/brx2.34Understanding the role of inflammation in sensorineural hearing loss: Current goals and future prospectsLiling Li0Dan Chen1Xuexin Lin2Jia Luo3Jingqian Tan4Peng Li5Department of Otolaryngology Head and Neck Surgery The Third Affiliated Hospital of Sun Yat‐Sen University Guangzhou Guangdong ChinaDepartment of Otolaryngology Head and Neck Surgery The Third Affiliated Hospital of Sun Yat‐Sen University Guangzhou Guangdong ChinaDepartment of Otolaryngology Head and Neck Surgery The Third Affiliated Hospital of Sun Yat‐Sen University Guangzhou Guangdong ChinaDepartment of Otolaryngology Head and Neck Surgery The Third Affiliated Hospital of Sun Yat‐Sen University Guangzhou Guangdong ChinaDepartment of Otolaryngology Head and Neck Surgery The Third Affiliated Hospital of Sun Yat‐Sen University Guangzhou Guangdong ChinaDepartment of Otolaryngology Head and Neck Surgery The Third Affiliated Hospital of Sun Yat‐Sen University Guangzhou Guangdong ChinaAbstract Sensorineural hearing loss (SNHL) is a common otologic condition caused by damage to hair cells and spiral ganglion neurons that affects transmission pathways. Most of these cells cannot be regenerated, and there has been no breakthrough in regeneration techniques for inner ear cells. SNHL has a high incidence rate and can cause a variety of clinical symptoms, greatly impacting people's daily lives. With limited clinical treatments, the search for critical targets is urgent. Studies have shown that inflammation is prevalent in the pathogenesis of SNHL and plays a significant role in it. Inflammation is a normal body defense response, and a systemic anti‐inflammatory approach is undesirable. It is crucial for us to identify potential targets of inflammation in SNHL and take measures specifically targeting those targets with minimal systemic impact. This paper firstly describes the role of inflammation in various types of SNHL and then provides an overview of the interactions between inflammation and cochlear immunity, cochlear microcirculation, vascular spasm, and glutamate metabolism and finally comprehensively examines the feasibility of targets in these interactions. This paper is expected to facilitate the development of targeted anti‐inflammation for SNHL and provide strategies and approaches for treating clinical SNHL.https://doi.org/10.1002/brx2.34auditory nervesblood labyrinth barriercytokinesinflammationsensorineural hearing loss |
| spellingShingle | Liling Li Dan Chen Xuexin Lin Jia Luo Jingqian Tan Peng Li Understanding the role of inflammation in sensorineural hearing loss: Current goals and future prospects Brain-X auditory nerves blood labyrinth barrier cytokines inflammation sensorineural hearing loss |
| title | Understanding the role of inflammation in sensorineural hearing loss: Current goals and future prospects |
| title_full | Understanding the role of inflammation in sensorineural hearing loss: Current goals and future prospects |
| title_fullStr | Understanding the role of inflammation in sensorineural hearing loss: Current goals and future prospects |
| title_full_unstemmed | Understanding the role of inflammation in sensorineural hearing loss: Current goals and future prospects |
| title_short | Understanding the role of inflammation in sensorineural hearing loss: Current goals and future prospects |
| title_sort | understanding the role of inflammation in sensorineural hearing loss current goals and future prospects |
| topic | auditory nerves blood labyrinth barrier cytokines inflammation sensorineural hearing loss |
| url | https://doi.org/10.1002/brx2.34 |
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