TNFα modulates PANX1 activation to promote ATP release and enhance P2RX7-mediated antitumor immune responses after chemotherapy in colorectal cancer

TNFα modulates PANX1 activation to promote ATP release and enhance P2RX7-mediated antitumor immune responses after chemotherapy in colorectal cancer

Abstract ATP and its receptor P2RX7 exert a pivotal effect on antitumor immunity during chemotherapy-induced immunogenic cell death (ICD). Here, we demonstrated that TNFα-mediated PANX1 cleavage was essential for ATP release in response to chemotherapy in colorectal cancer (CRC). TNFα promoted PANX1...

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Detalles Bibliográficos
Autores principales: Kevin Chih-Yang Huang, Shu-Fen Chiang, Pei-Chun Lin, Wei-Ze Hong, Pei-Chen Yang, Hui-Ping Chang, Shin-Lei Peng, Tsung-Wei Chen, Tao-Wei Ke, Ji-An Liang, William Tzu-Liang Chen, K. S. Clifford Chao
Formato: Artículo
Lenguaje:English
Publicado: Nature Publishing Group 2024-01-01
Colección:Cell Death and Disease
Acceso en línea:https://doi.org/10.1038/s41419-023-06408-5

Internet

https://doi.org/10.1038/s41419-023-06408-5

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