Assessment of the association between ACYP2 and laryngeal squamous cell carcinoma risk in Chinese males
Abstract Background Laryngeal squamous cell carcinoma (LSCC) is one of the most prevalent malignant neoplasms of the upper respiratory tract. Studies have confirmed that an unstable chromosome constitution promotes the progress of laryngeal tumorigenesis, and ACYP2 has been confirmed as a telomere l...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-07-01
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| Series: | Molecular Genetics & Genomic Medicine |
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| Online Access: | https://doi.org/10.1002/mgg3.731 |
| _version_ | 1818856712055029760 |
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| author | Wenhui Zhao Fanglin Niu Zhilan Xie Mengdan Yan Jingjie Li Yuan Zhang Jun Chen Qiufang Liu Tianbo Jin |
| author_facet | Wenhui Zhao Fanglin Niu Zhilan Xie Mengdan Yan Jingjie Li Yuan Zhang Jun Chen Qiufang Liu Tianbo Jin |
| author_sort | Wenhui Zhao |
| collection | DOAJ |
| description | Abstract Background Laryngeal squamous cell carcinoma (LSCC) is one of the most prevalent malignant neoplasms of the upper respiratory tract. Studies have confirmed that an unstable chromosome constitution promotes the progress of laryngeal tumorigenesis, and ACYP2 has been confirmed as a telomere length‐related gene. However, to date, the association between ACYP2 polymorphisms and LSCC susceptibility has not been investigated. Methods We performed this study to explore the effect of 11 single‐nucleotide polymorphisms (SNPs) in ACYP2 on LSCC susceptibility in Chinese Han males. Unconditional logistic regression analysis adjusted for age was used to calculate the odds ratios and 95% confidence intervals. Results Based on allele and genotype models, our results showed that rs1682111 variant was significantly associated with a decreased LSCC susceptibility (p < 0.05). On the contrary, polymorphisms of rs10439478, rs11125529, rs12615793, rs843711, rs11896604, and rs17045754 were significantly associated with an increased LSCC risk (p < 0.05). The results of haplotype analysis indicated that haplotypes “TTCTCG” and “TTCTAA” in block 1 and “TG” in block 2 showed a risk factor for the development of LCSS (p = 0.009, p < 0.001, and p = 0.001, respectively). The results of Genotype‐Tissue Expression analysis indicate that these significant SNPs were known to be associated with ACYP2 expression. Conclusion Our data demonstrated that ACYP2 polymorphisms may exert effects on LSCC susceptibility in Chinese Han males. |
| first_indexed | 2024-12-19T08:28:51Z |
| format | Article |
| id | doaj.art-9b9697519d104d98abe82f66b4c5a263 |
| institution | Directory Open Access Journal |
| issn | 2324-9269 |
| language | English |
| last_indexed | 2024-12-19T08:28:51Z |
| publishDate | 2019-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Molecular Genetics & Genomic Medicine |
| spelling | doaj.art-9b9697519d104d98abe82f66b4c5a2632022-12-21T20:29:15ZengWileyMolecular Genetics & Genomic Medicine2324-92692019-07-0177n/an/a10.1002/mgg3.731Assessment of the association between ACYP2 and laryngeal squamous cell carcinoma risk in Chinese malesWenhui Zhao0Fanglin Niu1Zhilan Xie2Mengdan Yan3Jingjie Li4Yuan Zhang5Jun Chen6Qiufang Liu7Tianbo Jin8Department of Anesthesiology Shaanxi Provincial Cancer Hospital Xi'an ChinaKey Laboratory of Resource Biology and Biotechnology in Western China Northwest University, Ministry of Education Xi’an ChinaKey Laboratory of Resource Biology and Biotechnology in Western China Northwest University, Ministry of Education Xi’an ChinaKey Laboratory of Resource Biology and Biotechnology in Western China Northwest University, Ministry of Education Xi’an ChinaKey Laboratory of Resource Biology and Biotechnology in Western China Northwest University, Ministry of Education Xi’an ChinaKey Laboratory of Resource Biology and Biotechnology in Western China Northwest University, Ministry of Education Xi’an ChinaDepartment of Anesthesiology Shaanxi Provincial Cancer Hospital Xi'an ChinaDepartment of Radiotherapy Shaanxi Provincial Cancer Hospital Affiliated to Medical College, Xi’an Jiaotong University Xi’an ChinaKey Laboratory of Resource Biology and Biotechnology in Western China Northwest University, Ministry of Education Xi’an ChinaAbstract Background Laryngeal squamous cell carcinoma (LSCC) is one of the most prevalent malignant neoplasms of the upper respiratory tract. Studies have confirmed that an unstable chromosome constitution promotes the progress of laryngeal tumorigenesis, and ACYP2 has been confirmed as a telomere length‐related gene. However, to date, the association between ACYP2 polymorphisms and LSCC susceptibility has not been investigated. Methods We performed this study to explore the effect of 11 single‐nucleotide polymorphisms (SNPs) in ACYP2 on LSCC susceptibility in Chinese Han males. Unconditional logistic regression analysis adjusted for age was used to calculate the odds ratios and 95% confidence intervals. Results Based on allele and genotype models, our results showed that rs1682111 variant was significantly associated with a decreased LSCC susceptibility (p < 0.05). On the contrary, polymorphisms of rs10439478, rs11125529, rs12615793, rs843711, rs11896604, and rs17045754 were significantly associated with an increased LSCC risk (p < 0.05). The results of haplotype analysis indicated that haplotypes “TTCTCG” and “TTCTAA” in block 1 and “TG” in block 2 showed a risk factor for the development of LCSS (p = 0.009, p < 0.001, and p = 0.001, respectively). The results of Genotype‐Tissue Expression analysis indicate that these significant SNPs were known to be associated with ACYP2 expression. Conclusion Our data demonstrated that ACYP2 polymorphisms may exert effects on LSCC susceptibility in Chinese Han males.https://doi.org/10.1002/mgg3.731ACYP2gene expressionlaryngeal squamous cell carcinoma (LSCC)single‐nucleotide polymorphisms (SNPs) |
| spellingShingle | Wenhui Zhao Fanglin Niu Zhilan Xie Mengdan Yan Jingjie Li Yuan Zhang Jun Chen Qiufang Liu Tianbo Jin Assessment of the association between ACYP2 and laryngeal squamous cell carcinoma risk in Chinese males Molecular Genetics & Genomic Medicine ACYP2 gene expression laryngeal squamous cell carcinoma (LSCC) single‐nucleotide polymorphisms (SNPs) |
| title | Assessment of the association between ACYP2 and laryngeal squamous cell carcinoma risk in Chinese males |
| title_full | Assessment of the association between ACYP2 and laryngeal squamous cell carcinoma risk in Chinese males |
| title_fullStr | Assessment of the association between ACYP2 and laryngeal squamous cell carcinoma risk in Chinese males |
| title_full_unstemmed | Assessment of the association between ACYP2 and laryngeal squamous cell carcinoma risk in Chinese males |
| title_short | Assessment of the association between ACYP2 and laryngeal squamous cell carcinoma risk in Chinese males |
| title_sort | assessment of the association between acyp2 and laryngeal squamous cell carcinoma risk in chinese males |
| topic | ACYP2 gene expression laryngeal squamous cell carcinoma (LSCC) single‐nucleotide polymorphisms (SNPs) |
| url | https://doi.org/10.1002/mgg3.731 |
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