Synthesis and Antiplasmodial Activity of Novel Fosmidomycin Derivatives and Conjugates with Artemisinin and Aminochloroquinoline

Synthesis and Antiplasmodial Activity of Novel Fosmidomycin Derivatives and Conjugates with Artemisinin and Aminochloroquinoline

Malaria, despite many efforts, remains among the most problematic infectious diseases worldwide, mainly due to the development of drug resistance by <i>Plasmodium falciparum.</i> The antibiotic fosmidomycin (FSM) is also known for its antimalarial activity by targeting the non-mevalonate...

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Bibliographic Details
Main Authors: Despina Palla, Antonia I. Antoniou, Michel Baltas, Christophe Menendez, Philippe Grellier, Elisabeth Mouray, Constantinos M. Athanassopoulos
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Molecules
Subjects:
fosmidomycin
chloroquine
artemisinin
hybrid
conjugates
antimalarial activity
Online Access:https://www.mdpi.com/1420-3049/25/20/4858

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