Use of varenicline for more than 12 months for smoking cessation in heavy chronic obstructive pulmonary disease smokers unmotivated to quit: a pilot study
Introduction: Use of varenicline for as long as necessary to achieve abstinence has not been studied. The aim of this study was to test whether smokers with mild-to-moderate chronic obstructive pulmonary disease (COPD) are able to quit if they use varenicline for a sufficient length of time. Methods...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2016-10-01
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| Series: | Therapeutic Advances in Respiratory Disease |
| Online Access: | https://doi.org/10.1177/1753465816654823 |
| _version_ | 1828885590432546816 |
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| author | Raúl H. Sansores Alejandra Ramírez-Venegas Rosario Arellano-Rocha Valeri Noé-Díaz Leonor García-Gómez Oliver Pérez Bautista Mónica Velázquez Uncal |
| author_facet | Raúl H. Sansores Alejandra Ramírez-Venegas Rosario Arellano-Rocha Valeri Noé-Díaz Leonor García-Gómez Oliver Pérez Bautista Mónica Velázquez Uncal |
| author_sort | Raúl H. Sansores |
| collection | DOAJ |
| description | Introduction: Use of varenicline for as long as necessary to achieve abstinence has not been studied. The aim of this study was to test whether smokers with mild-to-moderate chronic obstructive pulmonary disease (COPD) are able to quit if they use varenicline for a sufficient length of time. Methods: A total of 30 heavy smokers with COPD took varenicline for sufficiently long enough for smoking cessation. Smokers were allowed to smoke without a fixed quit date. The main endpoints were the time of voluntary abstinence (VA) and the continuous abstinence rate (CAR) at 12 and 18 months. Results: Of 28 subjects, eight subjects continued to smoke and 20 subjects stopped smoking, demonstrating a CAR up to 18 months (71%). Median time of treatment was 6 (range 3–24) and 2 (range 1–8) months for abstainers and non-abstainers, respectively, and the median time of VA for abstainers was 4 (range 1–21) months. Conclusions: Use of varenicline for more than the traditional 12 recommended weeks may be a good strategy to increase the cessation rate in heavy smokers with mild COPD. |
| first_indexed | 2024-12-13T11:29:22Z |
| format | Article |
| id | doaj.art-9b978c4092c34f44806f4b9094a90914 |
| institution | Directory Open Access Journal |
| issn | 1753-4658 1753-4666 |
| language | English |
| last_indexed | 2024-12-13T11:29:22Z |
| publishDate | 2016-10-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Therapeutic Advances in Respiratory Disease |
| spelling | doaj.art-9b978c4092c34f44806f4b9094a909142022-12-21T23:48:01ZengSAGE PublishingTherapeutic Advances in Respiratory Disease1753-46581753-46662016-10-011010.1177/1753465816654823Use of varenicline for more than 12 months for smoking cessation in heavy chronic obstructive pulmonary disease smokers unmotivated to quit: a pilot studyRaúl H. SansoresAlejandra Ramírez-VenegasRosario Arellano-RochaValeri Noé-DíazLeonor García-GómezOliver Pérez BautistaMónica Velázquez UncalIntroduction: Use of varenicline for as long as necessary to achieve abstinence has not been studied. The aim of this study was to test whether smokers with mild-to-moderate chronic obstructive pulmonary disease (COPD) are able to quit if they use varenicline for a sufficient length of time. Methods: A total of 30 heavy smokers with COPD took varenicline for sufficiently long enough for smoking cessation. Smokers were allowed to smoke without a fixed quit date. The main endpoints were the time of voluntary abstinence (VA) and the continuous abstinence rate (CAR) at 12 and 18 months. Results: Of 28 subjects, eight subjects continued to smoke and 20 subjects stopped smoking, demonstrating a CAR up to 18 months (71%). Median time of treatment was 6 (range 3–24) and 2 (range 1–8) months for abstainers and non-abstainers, respectively, and the median time of VA for abstainers was 4 (range 1–21) months. Conclusions: Use of varenicline for more than the traditional 12 recommended weeks may be a good strategy to increase the cessation rate in heavy smokers with mild COPD.https://doi.org/10.1177/1753465816654823 |
| spellingShingle | Raúl H. Sansores Alejandra Ramírez-Venegas Rosario Arellano-Rocha Valeri Noé-Díaz Leonor García-Gómez Oliver Pérez Bautista Mónica Velázquez Uncal Use of varenicline for more than 12 months for smoking cessation in heavy chronic obstructive pulmonary disease smokers unmotivated to quit: a pilot study Therapeutic Advances in Respiratory Disease |
| title | Use of varenicline for more than 12 months for smoking cessation in heavy chronic obstructive pulmonary disease smokers unmotivated to quit: a pilot study |
| title_full | Use of varenicline for more than 12 months for smoking cessation in heavy chronic obstructive pulmonary disease smokers unmotivated to quit: a pilot study |
| title_fullStr | Use of varenicline for more than 12 months for smoking cessation in heavy chronic obstructive pulmonary disease smokers unmotivated to quit: a pilot study |
| title_full_unstemmed | Use of varenicline for more than 12 months for smoking cessation in heavy chronic obstructive pulmonary disease smokers unmotivated to quit: a pilot study |
| title_short | Use of varenicline for more than 12 months for smoking cessation in heavy chronic obstructive pulmonary disease smokers unmotivated to quit: a pilot study |
| title_sort | use of varenicline for more than 12 months for smoking cessation in heavy chronic obstructive pulmonary disease smokers unmotivated to quit a pilot study |
| url | https://doi.org/10.1177/1753465816654823 |
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