Corneal Graft Success Rates in HSV Keratitis: A Systematic Review
Herpes Simplex Virus (HSV) has worldwide prevalence. The primary objective of this systematic review was to compare penetrating keratoplasty (PK) and deep anterior lamellar keratoplasty (DALK) regarding the efficacy and complications of the treatment of corneal scarring caused by herpes simplex kera...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Karolinum Press
2020-01-01
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| Series: | Acta Medica |
| Subjects: | |
| Online Access: | https://actamedica.lfhk.cuni.cz/63/4/0150/ |
| _version_ | 1818644651565907968 |
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| author | Konstantinos Skarentzos Eleftherios Chatzimichael Eirini-Kanella Panagiotopoulou Sergios Taliantzis Aristeidis Konstantinidis Georgios Labiris |
| author_facet | Konstantinos Skarentzos Eleftherios Chatzimichael Eirini-Kanella Panagiotopoulou Sergios Taliantzis Aristeidis Konstantinidis Georgios Labiris |
| author_sort | Konstantinos Skarentzos |
| collection | DOAJ |
| description | Herpes Simplex Virus (HSV) has worldwide prevalence. The primary objective of this systematic review was to compare penetrating keratoplasty (PK) and deep anterior lamellar keratoplasty (DALK) regarding the efficacy and complications of the treatment of corneal scarring caused by herpes simplex keratitis. Out of the 469 articles identified during the combined search of the literature based on the PubMed and Cochrane libraries, 10 retrospective and 2 prospective studies published from January 2010 to December 2019 were included. The study outcomes indicated that both surgical approaches resulted in a comparable improvement of visual acuity (VA). However, DALK demonstrated fewer complications in the majority of studies. Higher graft survival rates were associated with higher acyclovir (ACV) doses (above 800 mg/day), topical steroid and antibiotic drops. In conclusion, in terms of postoperative VA, both PK and DALK demonstrate comparable efficacy. However, DALK, which is applied in less severe HSK cases, is associated with fewer complications and better graft survival rates. High dosages of ACV, topical steroids and antibiotics contribute significantly to improved postoperative outcomes. |
| first_indexed | 2024-12-17T00:18:14Z |
| format | Article |
| id | doaj.art-9b98fe2592454d6ba9067d8510743302 |
| institution | Directory Open Access Journal |
| issn | 1211-4286 1805-9694 |
| language | English |
| last_indexed | 2024-12-17T00:18:14Z |
| publishDate | 2020-01-01 |
| publisher | Karolinum Press |
| record_format | Article |
| series | Acta Medica |
| spelling | doaj.art-9b98fe2592454d6ba9067d85107433022022-12-21T22:10:38ZengKarolinum PressActa Medica1211-42861805-96942020-01-0163415015810.14712/18059694.2020.57Corneal Graft Success Rates in HSV Keratitis: A Systematic ReviewKonstantinos Skarentzos0Eleftherios Chatzimichael1Eirini-Kanella Panagiotopoulou2Sergios Taliantzis3Aristeidis Konstantinidis4Georgios Labiris5Department of Ophthalmology, University Hospital of Alexandroupolis, Dragana, Alexandroupolis, GreeceDepartment of Ophthalmology, University Hospital of Alexandroupolis, Dragana, Alexandroupolis, GreeceDepartment of Ophthalmology, University Hospital of Alexandroupolis, Dragana, Alexandroupolis, GreeceDepartment of Ophthalmology, University Hospital of Alexandroupolis, Dragana, Alexandroupolis, GreeceDepartment of Ophthalmology, University Hospital of Alexandroupolis, Dragana, Alexandroupolis, GreeceDepartment of Ophthalmology, University Hospital of Alexandroupolis, Dragana, Alexandroupolis, GreeceHerpes Simplex Virus (HSV) has worldwide prevalence. The primary objective of this systematic review was to compare penetrating keratoplasty (PK) and deep anterior lamellar keratoplasty (DALK) regarding the efficacy and complications of the treatment of corneal scarring caused by herpes simplex keratitis. Out of the 469 articles identified during the combined search of the literature based on the PubMed and Cochrane libraries, 10 retrospective and 2 prospective studies published from January 2010 to December 2019 were included. The study outcomes indicated that both surgical approaches resulted in a comparable improvement of visual acuity (VA). However, DALK demonstrated fewer complications in the majority of studies. Higher graft survival rates were associated with higher acyclovir (ACV) doses (above 800 mg/day), topical steroid and antibiotic drops. In conclusion, in terms of postoperative VA, both PK and DALK demonstrate comparable efficacy. However, DALK, which is applied in less severe HSK cases, is associated with fewer complications and better graft survival rates. High dosages of ACV, topical steroids and antibiotics contribute significantly to improved postoperative outcomes.https://actamedica.lfhk.cuni.cz/63/4/0150/herpes simplex virusherpes simplex keratitispenetrating keratoplastydeep anterior lamellar keratoplastysystematic review |
| spellingShingle | Konstantinos Skarentzos Eleftherios Chatzimichael Eirini-Kanella Panagiotopoulou Sergios Taliantzis Aristeidis Konstantinidis Georgios Labiris Corneal Graft Success Rates in HSV Keratitis: A Systematic Review Acta Medica herpes simplex virus herpes simplex keratitis penetrating keratoplasty deep anterior lamellar keratoplasty systematic review |
| title | Corneal Graft Success Rates in HSV Keratitis: A Systematic Review |
| title_full | Corneal Graft Success Rates in HSV Keratitis: A Systematic Review |
| title_fullStr | Corneal Graft Success Rates in HSV Keratitis: A Systematic Review |
| title_full_unstemmed | Corneal Graft Success Rates in HSV Keratitis: A Systematic Review |
| title_short | Corneal Graft Success Rates in HSV Keratitis: A Systematic Review |
| title_sort | corneal graft success rates in hsv keratitis a systematic review |
| topic | herpes simplex virus herpes simplex keratitis penetrating keratoplasty deep anterior lamellar keratoplasty systematic review |
| url | https://actamedica.lfhk.cuni.cz/63/4/0150/ |
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