Maternal allo anti-M antibody-induced hemolytic disease of newborn
Hemolytic disease of the fetus and newborn is a syndrome associated with immune destruction of the fetal and newborn red cells by maternal red cell alloantibodies. The detection of anti-M in antenatal screening can be responsible for neonatal red cell aplasia. A 32-h-old full-term neonate admitted w...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Asian Journal of Transfusion Science |
| Subjects: | |
| Online Access: | http://www.ajts.org/article.asp?issn=0973-6247;year=2022;volume=16;issue=1;spage=144;epage=147;aulast= |
| _version_ | 1818503450728595456 |
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| author | Ashly Monson Mathew Sangita Shah Nidhi Bhatnagar Mamta Shah Tarak Patel Truptee Thakkar |
| author_facet | Ashly Monson Mathew Sangita Shah Nidhi Bhatnagar Mamta Shah Tarak Patel Truptee Thakkar |
| author_sort | Ashly Monson Mathew |
| collection | DOAJ |
| description | Hemolytic disease of the fetus and newborn is a syndrome associated with immune destruction of the fetal and newborn red cells by maternal red cell alloantibodies. The detection of anti-M in antenatal screening can be responsible for neonatal red cell aplasia. A 32-h-old full-term neonate admitted with inconsolable cry and mild fever. Laboratory tests revealed progressive anemia and hyperbilirubinemia on day 3. The peripheral blood smear showed evidence of hemolysis and reticulocyte count was reduced. Intensive phototherapy and antibiotics were started after ruling out other causes of hyperbilirubinemia. Blood group typing and advanced red cell serology workup were done. Antibody screening and identification was suggestive of the presence of anti-M antibody in both mother and baby. Intravenous immunoglobulin and red blood cell transfusions were given. Anti-M is capable of causing hemolytic disease of the fetus and newborn and prolonged anemia. Newborns with anemia should be evaluated for all the possible causes to establish a diagnosis. |
| first_indexed | 2024-12-10T21:24:10Z |
| format | Article |
| id | doaj.art-9b9971a701fc4635a0136867b2aa28e7 |
| institution | Directory Open Access Journal |
| issn | 0973-6247 1998-3565 |
| language | English |
| last_indexed | 2024-12-10T21:24:10Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Journal of Transfusion Science |
| spelling | doaj.art-9b9971a701fc4635a0136867b2aa28e72022-12-22T01:33:02ZengWolters Kluwer Medknow PublicationsAsian Journal of Transfusion Science0973-62471998-35652022-01-0116114414710.4103/ajts.ajts_109_21Maternal allo anti-M antibody-induced hemolytic disease of newbornAshly Monson MathewSangita ShahNidhi BhatnagarMamta ShahTarak PatelTruptee ThakkarHemolytic disease of the fetus and newborn is a syndrome associated with immune destruction of the fetal and newborn red cells by maternal red cell alloantibodies. The detection of anti-M in antenatal screening can be responsible for neonatal red cell aplasia. A 32-h-old full-term neonate admitted with inconsolable cry and mild fever. Laboratory tests revealed progressive anemia and hyperbilirubinemia on day 3. The peripheral blood smear showed evidence of hemolysis and reticulocyte count was reduced. Intensive phototherapy and antibiotics were started after ruling out other causes of hyperbilirubinemia. Blood group typing and advanced red cell serology workup were done. Antibody screening and identification was suggestive of the presence of anti-M antibody in both mother and baby. Intravenous immunoglobulin and red blood cell transfusions were given. Anti-M is capable of causing hemolytic disease of the fetus and newborn and prolonged anemia. Newborns with anemia should be evaluated for all the possible causes to establish a diagnosis.http://www.ajts.org/article.asp?issn=0973-6247;year=2022;volume=16;issue=1;spage=144;epage=147;aulast=alloantibodyanti-mhemolytic diseasered cell serology |
| spellingShingle | Ashly Monson Mathew Sangita Shah Nidhi Bhatnagar Mamta Shah Tarak Patel Truptee Thakkar Maternal allo anti-M antibody-induced hemolytic disease of newborn Asian Journal of Transfusion Science alloantibody anti-m hemolytic disease red cell serology |
| title | Maternal allo anti-M antibody-induced hemolytic disease of newborn |
| title_full | Maternal allo anti-M antibody-induced hemolytic disease of newborn |
| title_fullStr | Maternal allo anti-M antibody-induced hemolytic disease of newborn |
| title_full_unstemmed | Maternal allo anti-M antibody-induced hemolytic disease of newborn |
| title_short | Maternal allo anti-M antibody-induced hemolytic disease of newborn |
| title_sort | maternal allo anti m antibody induced hemolytic disease of newborn |
| topic | alloantibody anti-m hemolytic disease red cell serology |
| url | http://www.ajts.org/article.asp?issn=0973-6247;year=2022;volume=16;issue=1;spage=144;epage=147;aulast= |
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