Influence of Free Radicals in the Origin of Atherosclerosis
Most of the pathologic components of oxidative stress of cardiovascular diseases are closely related with diregulation of metabolism of reactive species of oxygen, which favor the appearance of the so called oxidative stress. The oxidation of low density lipoproteins, endothelial dysfunction and inf...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Spanish |
| Published: |
Universidad de las Ciencias Médicas de Cienfuegos
2020-06-01
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| Series: | Revista Finlay |
| Subjects: | |
| Online Access: | https://revfinlay.sld.cu/index.php/finlay/article/view/718 |
| _version_ | 1797301733183979520 |
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| author | Yoel Hernández Guerra Alain Rodríguez Gómez Janet Villafuerte Reinante Ignacio Marrero Silva Carlos Manuel Mora Hernández |
| author_facet | Yoel Hernández Guerra Alain Rodríguez Gómez Janet Villafuerte Reinante Ignacio Marrero Silva Carlos Manuel Mora Hernández |
| author_sort | Yoel Hernández Guerra |
| collection | DOAJ |
| description | Most of the pathologic components of oxidative stress of cardiovascular diseases are closely related with diregulation of metabolism of reactive species of oxygen, which favor the appearance of the so called oxidative stress. The oxidation of low density lipoproteins, endothelial dysfunction and inflammatory processes are mediated in some way by cellular production of the reactive oxygen species. This review is conducted aimed at revising the latest findings that explain the influence of free radicals in the origin of atherosclerosis. It is concluded that oxygen is the main source of free radical formation whose action is determinant for the genesis of atherosclerosis. The increase of oxidative stress favors atherothrombatic phases: platelet adhesion and aggregation, cell proliferation, lipid and protein perioxidation, irreversible damage in DNA and mitochondrial membrane and inestabilzation/desestabilization of the plaque. |
| first_indexed | 2024-03-07T23:26:55Z |
| format | Article |
| id | doaj.art-9b9b8af5d4cc4837ab5c41606a611ad7 |
| institution | Directory Open Access Journal |
| issn | 2221-2434 |
| language | Spanish |
| last_indexed | 2024-03-07T23:26:55Z |
| publishDate | 2020-06-01 |
| publisher | Universidad de las Ciencias Médicas de Cienfuegos |
| record_format | Article |
| series | Revista Finlay |
| spelling | doaj.art-9b9b8af5d4cc4837ab5c41606a611ad72024-02-21T02:59:19ZspaUniversidad de las Ciencias Médicas de CienfuegosRevista Finlay2221-24342020-06-01102170178442Influence of Free Radicals in the Origin of AtherosclerosisYoel Hernández Guerra0Alain Rodríguez Gómez1Janet Villafuerte Reinante2Ignacio Marrero Silva3Carlos Manuel Mora Hernández4Universidad de Ciencias Médicas de Cienfuegos. Cienfuegos.Policlínico Comunitario José Luis Chaviano. Cienfuegos.Universidad de Ciencias Médicas de Cienfuegos. Cienfuegos.Universidad de Ciencias Médicas de Cienfuegos. Cienfuegos.Universidad de Ciencias Médicas de Cienfuegos. Cienfuegos.Most of the pathologic components of oxidative stress of cardiovascular diseases are closely related with diregulation of metabolism of reactive species of oxygen, which favor the appearance of the so called oxidative stress. The oxidation of low density lipoproteins, endothelial dysfunction and inflammatory processes are mediated in some way by cellular production of the reactive oxygen species. This review is conducted aimed at revising the latest findings that explain the influence of free radicals in the origin of atherosclerosis. It is concluded that oxygen is the main source of free radical formation whose action is determinant for the genesis of atherosclerosis. The increase of oxidative stress favors atherothrombatic phases: platelet adhesion and aggregation, cell proliferation, lipid and protein perioxidation, irreversible damage in DNA and mitochondrial membrane and inestabilzation/desestabilization of the plaque.https://revfinlay.sld.cu/index.php/finlay/article/view/718aterosclerosisradicales libresestrés oxidativo |
| spellingShingle | Yoel Hernández Guerra Alain Rodríguez Gómez Janet Villafuerte Reinante Ignacio Marrero Silva Carlos Manuel Mora Hernández Influence of Free Radicals in the Origin of Atherosclerosis Revista Finlay aterosclerosis radicales libres estrés oxidativo |
| title | Influence of Free Radicals in the Origin of Atherosclerosis |
| title_full | Influence of Free Radicals in the Origin of Atherosclerosis |
| title_fullStr | Influence of Free Radicals in the Origin of Atherosclerosis |
| title_full_unstemmed | Influence of Free Radicals in the Origin of Atherosclerosis |
| title_short | Influence of Free Radicals in the Origin of Atherosclerosis |
| title_sort | influence of free radicals in the origin of atherosclerosis |
| topic | aterosclerosis radicales libres estrés oxidativo |
| url | https://revfinlay.sld.cu/index.php/finlay/article/view/718 |
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