Subcellular localization of hippocampal ryanodine receptor 2 and its role in neuronal excitability and memory

A mouse model containing a GFP-tagged ryanodine receptor 2 (RyR2) has shed light on the precise subcellular localization of hippocampal RyR2 and mechanisms underlying neuronal excitability, learning, and memory.

Bibliographic Details
Main Authors: Florian Hiess, Jinjing Yao, Zhenpeng Song, Bo Sun, Zizhen Zhang, Junting Huang, Lina Chen, Adam Institoris, John Paul Estillore, Ruiwu Wang, Henk E. D. J. ter Keurs, Peter K. Stys, Grant R. Gordon, Gerald W. Zamponi, Anutosh Ganguly, S. R. Wayne Chen
Format: Article
Language:English
Published: Nature Portfolio 2022-03-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-022-03124-2
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author Florian Hiess
Jinjing Yao
Zhenpeng Song
Bo Sun
Zizhen Zhang
Junting Huang
Lina Chen
Adam Institoris
John Paul Estillore
Ruiwu Wang
Henk E. D. J. ter Keurs
Peter K. Stys
Grant R. Gordon
Gerald W. Zamponi
Anutosh Ganguly
S. R. Wayne Chen
author_facet Florian Hiess
Jinjing Yao
Zhenpeng Song
Bo Sun
Zizhen Zhang
Junting Huang
Lina Chen
Adam Institoris
John Paul Estillore
Ruiwu Wang
Henk E. D. J. ter Keurs
Peter K. Stys
Grant R. Gordon
Gerald W. Zamponi
Anutosh Ganguly
S. R. Wayne Chen
author_sort Florian Hiess
collection DOAJ
description A mouse model containing a GFP-tagged ryanodine receptor 2 (RyR2) has shed light on the precise subcellular localization of hippocampal RyR2 and mechanisms underlying neuronal excitability, learning, and memory.
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spelling doaj.art-9b9b91a266df4b92bd4d0f52c3d1dc442022-12-21T20:00:40ZengNature PortfolioCommunications Biology2399-36422022-03-015111610.1038/s42003-022-03124-2Subcellular localization of hippocampal ryanodine receptor 2 and its role in neuronal excitability and memoryFlorian Hiess0Jinjing Yao1Zhenpeng Song2Bo Sun3Zizhen Zhang4Junting Huang5Lina Chen6Adam Institoris7John Paul Estillore8Ruiwu Wang9Henk E. D. J. ter Keurs10Peter K. Stys11Grant R. Gordon12Gerald W. Zamponi13Anutosh Ganguly14S. R. Wayne Chen15Libin Cardiovascular Institute, Department of Physiology and Pharmacology, University of CalgaryLibin Cardiovascular Institute, Department of Physiology and Pharmacology, University of CalgaryLibin Cardiovascular Institute, Department of Physiology and Pharmacology, University of CalgaryLibin Cardiovascular Institute, Department of Physiology and Pharmacology, University of CalgaryHotchkiss Brain Institute, Department of Physiology and Pharmacology, University of CalgaryHotchkiss Brain Institute, Department of Physiology and Pharmacology, University of CalgaryHotchkiss Brain Institute, Department of Physiology and Pharmacology, University of CalgaryHotchkiss Brain Institute, Department of Physiology and Pharmacology, University of CalgaryLibin Cardiovascular Institute, Department of Physiology and Pharmacology, University of CalgaryLibin Cardiovascular Institute, Department of Physiology and Pharmacology, University of CalgaryLibin Cardiovascular Institute, Department of Cardiovascular Science, Department of Medicine, University of CalgaryHotchkiss Brain Institute, Department of Physiology and Pharmacology, University of CalgaryHotchkiss Brain Institute, Department of Physiology and Pharmacology, University of CalgaryHotchkiss Brain Institute, Department of Physiology and Pharmacology, University of CalgaryDepartment of Microbiology, Immunology, and Infectious Diseases, University of CalgaryLibin Cardiovascular Institute, Department of Physiology and Pharmacology, University of CalgaryA mouse model containing a GFP-tagged ryanodine receptor 2 (RyR2) has shed light on the precise subcellular localization of hippocampal RyR2 and mechanisms underlying neuronal excitability, learning, and memory.https://doi.org/10.1038/s42003-022-03124-2
spellingShingle Florian Hiess
Jinjing Yao
Zhenpeng Song
Bo Sun
Zizhen Zhang
Junting Huang
Lina Chen
Adam Institoris
John Paul Estillore
Ruiwu Wang
Henk E. D. J. ter Keurs
Peter K. Stys
Grant R. Gordon
Gerald W. Zamponi
Anutosh Ganguly
S. R. Wayne Chen
Subcellular localization of hippocampal ryanodine receptor 2 and its role in neuronal excitability and memory
Communications Biology
title Subcellular localization of hippocampal ryanodine receptor 2 and its role in neuronal excitability and memory
title_full Subcellular localization of hippocampal ryanodine receptor 2 and its role in neuronal excitability and memory
title_fullStr Subcellular localization of hippocampal ryanodine receptor 2 and its role in neuronal excitability and memory
title_full_unstemmed Subcellular localization of hippocampal ryanodine receptor 2 and its role in neuronal excitability and memory
title_short Subcellular localization of hippocampal ryanodine receptor 2 and its role in neuronal excitability and memory
title_sort subcellular localization of hippocampal ryanodine receptor 2 and its role in neuronal excitability and memory
url https://doi.org/10.1038/s42003-022-03124-2
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