Subcellular localization of hippocampal ryanodine receptor 2 and its role in neuronal excitability and memory
A mouse model containing a GFP-tagged ryanodine receptor 2 (RyR2) has shed light on the precise subcellular localization of hippocampal RyR2 and mechanisms underlying neuronal excitability, learning, and memory.
Main Authors: | , , , , , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2022-03-01
|
Series: | Communications Biology |
Online Access: | https://doi.org/10.1038/s42003-022-03124-2 |
_version_ | 1818915655572783104 |
---|---|
author | Florian Hiess Jinjing Yao Zhenpeng Song Bo Sun Zizhen Zhang Junting Huang Lina Chen Adam Institoris John Paul Estillore Ruiwu Wang Henk E. D. J. ter Keurs Peter K. Stys Grant R. Gordon Gerald W. Zamponi Anutosh Ganguly S. R. Wayne Chen |
author_facet | Florian Hiess Jinjing Yao Zhenpeng Song Bo Sun Zizhen Zhang Junting Huang Lina Chen Adam Institoris John Paul Estillore Ruiwu Wang Henk E. D. J. ter Keurs Peter K. Stys Grant R. Gordon Gerald W. Zamponi Anutosh Ganguly S. R. Wayne Chen |
author_sort | Florian Hiess |
collection | DOAJ |
description | A mouse model containing a GFP-tagged ryanodine receptor 2 (RyR2) has shed light on the precise subcellular localization of hippocampal RyR2 and mechanisms underlying neuronal excitability, learning, and memory. |
first_indexed | 2024-12-20T00:05:44Z |
format | Article |
id | doaj.art-9b9b91a266df4b92bd4d0f52c3d1dc44 |
institution | Directory Open Access Journal |
issn | 2399-3642 |
language | English |
last_indexed | 2024-12-20T00:05:44Z |
publishDate | 2022-03-01 |
publisher | Nature Portfolio |
record_format | Article |
series | Communications Biology |
spelling | doaj.art-9b9b91a266df4b92bd4d0f52c3d1dc442022-12-21T20:00:40ZengNature PortfolioCommunications Biology2399-36422022-03-015111610.1038/s42003-022-03124-2Subcellular localization of hippocampal ryanodine receptor 2 and its role in neuronal excitability and memoryFlorian Hiess0Jinjing Yao1Zhenpeng Song2Bo Sun3Zizhen Zhang4Junting Huang5Lina Chen6Adam Institoris7John Paul Estillore8Ruiwu Wang9Henk E. D. J. ter Keurs10Peter K. Stys11Grant R. Gordon12Gerald W. Zamponi13Anutosh Ganguly14S. R. Wayne Chen15Libin Cardiovascular Institute, Department of Physiology and Pharmacology, University of CalgaryLibin Cardiovascular Institute, Department of Physiology and Pharmacology, University of CalgaryLibin Cardiovascular Institute, Department of Physiology and Pharmacology, University of CalgaryLibin Cardiovascular Institute, Department of Physiology and Pharmacology, University of CalgaryHotchkiss Brain Institute, Department of Physiology and Pharmacology, University of CalgaryHotchkiss Brain Institute, Department of Physiology and Pharmacology, University of CalgaryHotchkiss Brain Institute, Department of Physiology and Pharmacology, University of CalgaryHotchkiss Brain Institute, Department of Physiology and Pharmacology, University of CalgaryLibin Cardiovascular Institute, Department of Physiology and Pharmacology, University of CalgaryLibin Cardiovascular Institute, Department of Physiology and Pharmacology, University of CalgaryLibin Cardiovascular Institute, Department of Cardiovascular Science, Department of Medicine, University of CalgaryHotchkiss Brain Institute, Department of Physiology and Pharmacology, University of CalgaryHotchkiss Brain Institute, Department of Physiology and Pharmacology, University of CalgaryHotchkiss Brain Institute, Department of Physiology and Pharmacology, University of CalgaryDepartment of Microbiology, Immunology, and Infectious Diseases, University of CalgaryLibin Cardiovascular Institute, Department of Physiology and Pharmacology, University of CalgaryA mouse model containing a GFP-tagged ryanodine receptor 2 (RyR2) has shed light on the precise subcellular localization of hippocampal RyR2 and mechanisms underlying neuronal excitability, learning, and memory.https://doi.org/10.1038/s42003-022-03124-2 |
spellingShingle | Florian Hiess Jinjing Yao Zhenpeng Song Bo Sun Zizhen Zhang Junting Huang Lina Chen Adam Institoris John Paul Estillore Ruiwu Wang Henk E. D. J. ter Keurs Peter K. Stys Grant R. Gordon Gerald W. Zamponi Anutosh Ganguly S. R. Wayne Chen Subcellular localization of hippocampal ryanodine receptor 2 and its role in neuronal excitability and memory Communications Biology |
title | Subcellular localization of hippocampal ryanodine receptor 2 and its role in neuronal excitability and memory |
title_full | Subcellular localization of hippocampal ryanodine receptor 2 and its role in neuronal excitability and memory |
title_fullStr | Subcellular localization of hippocampal ryanodine receptor 2 and its role in neuronal excitability and memory |
title_full_unstemmed | Subcellular localization of hippocampal ryanodine receptor 2 and its role in neuronal excitability and memory |
title_short | Subcellular localization of hippocampal ryanodine receptor 2 and its role in neuronal excitability and memory |
title_sort | subcellular localization of hippocampal ryanodine receptor 2 and its role in neuronal excitability and memory |
url | https://doi.org/10.1038/s42003-022-03124-2 |
work_keys_str_mv | AT florianhiess subcellularlocalizationofhippocampalryanodinereceptor2anditsroleinneuronalexcitabilityandmemory AT jinjingyao subcellularlocalizationofhippocampalryanodinereceptor2anditsroleinneuronalexcitabilityandmemory AT zhenpengsong subcellularlocalizationofhippocampalryanodinereceptor2anditsroleinneuronalexcitabilityandmemory AT bosun subcellularlocalizationofhippocampalryanodinereceptor2anditsroleinneuronalexcitabilityandmemory AT zizhenzhang subcellularlocalizationofhippocampalryanodinereceptor2anditsroleinneuronalexcitabilityandmemory AT juntinghuang subcellularlocalizationofhippocampalryanodinereceptor2anditsroleinneuronalexcitabilityandmemory AT linachen subcellularlocalizationofhippocampalryanodinereceptor2anditsroleinneuronalexcitabilityandmemory AT adaminstitoris subcellularlocalizationofhippocampalryanodinereceptor2anditsroleinneuronalexcitabilityandmemory AT johnpaulestillore subcellularlocalizationofhippocampalryanodinereceptor2anditsroleinneuronalexcitabilityandmemory AT ruiwuwang subcellularlocalizationofhippocampalryanodinereceptor2anditsroleinneuronalexcitabilityandmemory AT henkedjterkeurs subcellularlocalizationofhippocampalryanodinereceptor2anditsroleinneuronalexcitabilityandmemory AT peterkstys subcellularlocalizationofhippocampalryanodinereceptor2anditsroleinneuronalexcitabilityandmemory AT grantrgordon subcellularlocalizationofhippocampalryanodinereceptor2anditsroleinneuronalexcitabilityandmemory AT geraldwzamponi subcellularlocalizationofhippocampalryanodinereceptor2anditsroleinneuronalexcitabilityandmemory AT anutoshganguly subcellularlocalizationofhippocampalryanodinereceptor2anditsroleinneuronalexcitabilityandmemory AT srwaynechen subcellularlocalizationofhippocampalryanodinereceptor2anditsroleinneuronalexcitabilityandmemory |