Towards an optimal model for gastric cancer peritoneal metastasis: current challenges and future directions
Summary: Peritoneal metastasis is a challenging aspect of clinical practice for gastric cancer. Animal models are crucial in understanding molecular mechanisms, assessing drug efficacy, and conducting clinical intervention studies, including those related to gastric cancer peritoneal metastasis. Unl...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-06-01
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| Series: | EBioMedicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352396423001664 |
| _version_ | 1797828131927621632 |
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| author | Zehui Li Jin Wang Zhenning Wang Yan Xu |
| author_facet | Zehui Li Jin Wang Zhenning Wang Yan Xu |
| author_sort | Zehui Li |
| collection | DOAJ |
| description | Summary: Peritoneal metastasis is a challenging aspect of clinical practice for gastric cancer. Animal models are crucial in understanding molecular mechanisms, assessing drug efficacy, and conducting clinical intervention studies, including those related to gastric cancer peritoneal metastasis. Unlike other xenograft models, peritoneal metastasis models should not only present tumor growth at the transplant site, but also recapitulate tumor cell metastasis in the abdominal cavity. Developing a reliable model of gastric cancer peritoneal metastasis involves several technical aspects, such as the selection of model animals, source of xenograft tumors, technology of transplantation, and dynamic monitoring of the tumor progression. To date, challenges remain in developing a reliable model that can completely recapitulate peritoneal metastasis. Thus, this review aims to summarize the techniques and strategies used to establish animal models of gastric cancer peritoneal metastasis, providing a reference for future model establishment. |
| first_indexed | 2024-04-09T12:59:48Z |
| format | Article |
| id | doaj.art-9b9d6f7fa83f4f0bbea3f4e707adeb2e |
| institution | Directory Open Access Journal |
| issn | 2352-3964 |
| language | English |
| last_indexed | 2024-04-09T12:59:48Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | EBioMedicine |
| spelling | doaj.art-9b9d6f7fa83f4f0bbea3f4e707adeb2e2023-05-13T04:25:16ZengElsevierEBioMedicine2352-39642023-06-0192104601Towards an optimal model for gastric cancer peritoneal metastasis: current challenges and future directionsZehui Li0Jin Wang1Zhenning Wang2Yan Xu3Department of Surgical Oncology and General Surgery, First Hospital of China Medical University, Shenyang, 110001, PR ChinaDepartment of E.N.T., Shengjing Hospital of China Medical University, Shenyang, 110003, PR ChinaDepartment of Surgical Oncology and General Surgery, First Hospital of China Medical University, Shenyang, 110001, PR China; Corresponding author.Department of Surgical Oncology and General Surgery, First Hospital of China Medical University, Shenyang, 110001, PR China; Corresponding author.Summary: Peritoneal metastasis is a challenging aspect of clinical practice for gastric cancer. Animal models are crucial in understanding molecular mechanisms, assessing drug efficacy, and conducting clinical intervention studies, including those related to gastric cancer peritoneal metastasis. Unlike other xenograft models, peritoneal metastasis models should not only present tumor growth at the transplant site, but also recapitulate tumor cell metastasis in the abdominal cavity. Developing a reliable model of gastric cancer peritoneal metastasis involves several technical aspects, such as the selection of model animals, source of xenograft tumors, technology of transplantation, and dynamic monitoring of the tumor progression. To date, challenges remain in developing a reliable model that can completely recapitulate peritoneal metastasis. Thus, this review aims to summarize the techniques and strategies used to establish animal models of gastric cancer peritoneal metastasis, providing a reference for future model establishment.http://www.sciencedirect.com/science/article/pii/S2352396423001664Gastric cancerPeritoneal metastasisAnimal modelImmunodeficient mousePatient-derived xenograft (PDX)Cell line-derived xenograft (CDX) |
| spellingShingle | Zehui Li Jin Wang Zhenning Wang Yan Xu Towards an optimal model for gastric cancer peritoneal metastasis: current challenges and future directions EBioMedicine Gastric cancer Peritoneal metastasis Animal model Immunodeficient mouse Patient-derived xenograft (PDX) Cell line-derived xenograft (CDX) |
| title | Towards an optimal model for gastric cancer peritoneal metastasis: current challenges and future directions |
| title_full | Towards an optimal model for gastric cancer peritoneal metastasis: current challenges and future directions |
| title_fullStr | Towards an optimal model for gastric cancer peritoneal metastasis: current challenges and future directions |
| title_full_unstemmed | Towards an optimal model for gastric cancer peritoneal metastasis: current challenges and future directions |
| title_short | Towards an optimal model for gastric cancer peritoneal metastasis: current challenges and future directions |
| title_sort | towards an optimal model for gastric cancer peritoneal metastasis current challenges and future directions |
| topic | Gastric cancer Peritoneal metastasis Animal model Immunodeficient mouse Patient-derived xenograft (PDX) Cell line-derived xenograft (CDX) |
| url | http://www.sciencedirect.com/science/article/pii/S2352396423001664 |
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