Comparative Dosimetric Evaluation of Volumetric-Modulated Arc Therapy (VMAT) Versus Intensity-Modulated Radiotherapy (IMRT) in Thoracic Esophageal Cancer
Introduction: With the introduction of Intensity Modulated Radiotherapy (IMRT) approach, better dosimetry results and patient outcomes has been attained for various anatomical sites. In present study, a comparative dosimetric evaluation of Volumetric-Modulated Arc Therapy (VMAT) versus two technique...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2023-05-01
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| Series: | Iranian Journal of Medical Physics |
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| Online Access: | https://ijmp.mums.ac.ir/article_20462_83410eafb13e35fed436d5577a53d049.pdf |
| _version_ | 1827284526612611072 |
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| author | Atul Mishra Ramji Pathak Kailash Mittal SURENDRA MISHRA Sudesh Singh Anoop Srivastava |
| author_facet | Atul Mishra Ramji Pathak Kailash Mittal SURENDRA MISHRA Sudesh Singh Anoop Srivastava |
| author_sort | Atul Mishra |
| collection | DOAJ |
| description | Introduction: With the introduction of Intensity Modulated Radiotherapy (IMRT) approach, better dosimetry results and patient outcomes has been attained for various anatomical sites. In present study, a comparative dosimetric evaluation of Volumetric-Modulated Arc Therapy (VMAT) versus two techniques of IMRT i.e. Dynamic IMRT (d-IMRT) and step & shoot IMRT (ss-IMRT) was done for thoracic esophageal cancer.Material and Methods: VMAT, ss-IMRT, and d-IMRT plans were generated on the Computed Tomography Simulator data sets of 13 Patients with thoracic esophageal carcinoma who had been treated earlier. The prescription dose for each patient was 50.4 Gy in 28 fractions. All the plans were optimized to achieve greater or equal to 95% of the prescribed dose to the Planning Target Volume (PTV). Dose to PTV and organ at risk (OAR) were compared with the help of Dose Volume Histogram (DVH).Results: VMAT and d-IMRT plans were nearly equivalent for PTV coverage, homogeneity index (HI), and uniformity index (UI) (p> 0.05). However, VMAT and d-IMRT plans had superior PTV coverage, HI, and UI, (p < 0.01) than ss-IMRT. For PTV, the Dmean, D98, and D95 values in ss-IMRT were significantly less than VMAT and d-IMRT (p< 0.05).Conclusion: All three techniques are able to provide a homogeneous and conformal dose distribution. VMAT offers better homogeneous dose distribution and may be preferred for treating thoracic esophageal carcinoma. Thus, the multi-arc VMAT technique may be a better option with equivalent or superior dose distribution, uniformity, and homogeneity. |
| first_indexed | 2024-04-24T09:57:51Z |
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| institution | Directory Open Access Journal |
| issn | 2345-3672 |
| language | English |
| last_indexed | 2024-04-24T09:57:51Z |
| publishDate | 2023-05-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Medical Physics |
| spelling | doaj.art-9b9e424d1d1b4aa0b67b3c78cb7e3f5b2024-04-14T06:28:22ZengMashhad University of Medical SciencesIranian Journal of Medical Physics2345-36722023-05-0120315916710.22038/ijmp.2022.61938.204720462Comparative Dosimetric Evaluation of Volumetric-Modulated Arc Therapy (VMAT) Versus Intensity-Modulated Radiotherapy (IMRT) in Thoracic Esophageal CancerAtul Mishra0Ramji Pathak1Kailash Mittal2SURENDRA MISHRA3Sudesh Singh4Anoop Srivastava5Department of Physics, Tilak Dhari P. G. College, Jaunpur, (U.P.) - 222002, INDIA and Department of Radiation Oncology, Lecturer(Physicist), Uttar Pradesh University of Medical Sciences, Saifai etawah-UP 206130 IndiaDepartment of Physics, Tilak Dhari P. G. College, Jaunpur, (U.P.) - 222002, INDIADepartment of Radiation Oncology, Uttar Pradesh University of Medical Sciences, Saifai, Etawah (U.P.) - 206130, INDIADepartment of Radiation Oncology, Dr. Ram Manohar Lohia Institute of Medical Sciences, Vibhuti Khand Gomti Nagar, Lucknow -226010Department of Physics, Tilak Dhari P. G. College, Jaunpur, (U.P.) - 222002, INDIADepartment of Radiation Oncology, Dr. Ram Manohar Lohia Institute of Medical Sciences, Vibhuti Khand Gomti Nagar, Lucknow -226010 IndiaIntroduction: With the introduction of Intensity Modulated Radiotherapy (IMRT) approach, better dosimetry results and patient outcomes has been attained for various anatomical sites. In present study, a comparative dosimetric evaluation of Volumetric-Modulated Arc Therapy (VMAT) versus two techniques of IMRT i.e. Dynamic IMRT (d-IMRT) and step & shoot IMRT (ss-IMRT) was done for thoracic esophageal cancer.Material and Methods: VMAT, ss-IMRT, and d-IMRT plans were generated on the Computed Tomography Simulator data sets of 13 Patients with thoracic esophageal carcinoma who had been treated earlier. The prescription dose for each patient was 50.4 Gy in 28 fractions. All the plans were optimized to achieve greater or equal to 95% of the prescribed dose to the Planning Target Volume (PTV). Dose to PTV and organ at risk (OAR) were compared with the help of Dose Volume Histogram (DVH).Results: VMAT and d-IMRT plans were nearly equivalent for PTV coverage, homogeneity index (HI), and uniformity index (UI) (p> 0.05). However, VMAT and d-IMRT plans had superior PTV coverage, HI, and UI, (p < 0.01) than ss-IMRT. For PTV, the Dmean, D98, and D95 values in ss-IMRT were significantly less than VMAT and d-IMRT (p< 0.05).Conclusion: All three techniques are able to provide a homogeneous and conformal dose distribution. VMAT offers better homogeneous dose distribution and may be preferred for treating thoracic esophageal carcinoma. Thus, the multi-arc VMAT technique may be a better option with equivalent or superior dose distribution, uniformity, and homogeneity.https://ijmp.mums.ac.ir/article_20462_83410eafb13e35fed436d5577a53d049.pdfradiotherapydosimetryesophaguscomputed tomographyintensity modulatedradiotherapy planninghomogeneity indexconformity index |
| spellingShingle | Atul Mishra Ramji Pathak Kailash Mittal SURENDRA MISHRA Sudesh Singh Anoop Srivastava Comparative Dosimetric Evaluation of Volumetric-Modulated Arc Therapy (VMAT) Versus Intensity-Modulated Radiotherapy (IMRT) in Thoracic Esophageal Cancer Iranian Journal of Medical Physics radiotherapy dosimetry esophagus computed tomography intensity modulated radiotherapy planning homogeneity index conformity index |
| title | Comparative Dosimetric Evaluation of Volumetric-Modulated Arc Therapy (VMAT) Versus Intensity-Modulated Radiotherapy (IMRT) in Thoracic Esophageal Cancer |
| title_full | Comparative Dosimetric Evaluation of Volumetric-Modulated Arc Therapy (VMAT) Versus Intensity-Modulated Radiotherapy (IMRT) in Thoracic Esophageal Cancer |
| title_fullStr | Comparative Dosimetric Evaluation of Volumetric-Modulated Arc Therapy (VMAT) Versus Intensity-Modulated Radiotherapy (IMRT) in Thoracic Esophageal Cancer |
| title_full_unstemmed | Comparative Dosimetric Evaluation of Volumetric-Modulated Arc Therapy (VMAT) Versus Intensity-Modulated Radiotherapy (IMRT) in Thoracic Esophageal Cancer |
| title_short | Comparative Dosimetric Evaluation of Volumetric-Modulated Arc Therapy (VMAT) Versus Intensity-Modulated Radiotherapy (IMRT) in Thoracic Esophageal Cancer |
| title_sort | comparative dosimetric evaluation of volumetric modulated arc therapy vmat versus intensity modulated radiotherapy imrt in thoracic esophageal cancer |
| topic | radiotherapy dosimetry esophagus computed tomography intensity modulated radiotherapy planning homogeneity index conformity index |
| url | https://ijmp.mums.ac.ir/article_20462_83410eafb13e35fed436d5577a53d049.pdf |
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