Priming With Recombinant BCG Expressing Novel HIV-1 Conserved Mosaic Immunogens and Boosting With Recombinant ChAdOx1 Is Safe, Stable, and Elicits HIV-1-Specific T-Cell Responses in BALB/c Mice

Priming With Recombinant BCG Expressing Novel HIV-1 Conserved Mosaic Immunogens and Boosting With Recombinant ChAdOx1 Is Safe, Stable, and Elicits HIV-1-Specific T-Cell Responses in BALB/c Mice

BCG is currently the only licensed vaccine against tuberculosis (TB) and confers protection against meningitis and miliary tuberculosis in infants, although pulmonary disease protection in adults is inconsistent. Recently, promising HIV-1 immunogens were developed, such as the T-cell immunogens “tHI...

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Bibliographic Details
Main Authors: Athina Kilpeläinen, Narcís Saubi, Núria Guitart, Nathifa Moyo, Edmund G. Wee, Krupa Ravi, Tomáš Hanke, Joan Joseph
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Immunology
Subjects:
mycobacteria
HIV
conserved
vaccine
rBCG
live-attenuated vaccines
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00923/full

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