Prenatal exposures and exposomics of asthma
This review examines the causal investigation of preclinical development of childhood asthma using exposomic tools. We examine the current state of knowledge regarding early-life exposure to non-biogenic indoor air pollution and the developmental modulation of the immune system. We examine how metab...
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| Format: | Article |
| Language: | English |
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AIMS Press
2015-02-01
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| Series: | AIMS Environmental Science |
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| _version_ | 1818278972921741312 |
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| author | Hyunok Choi Mark T. McAuley David A. Lawrence |
| author_facet | Hyunok Choi Mark T. McAuley David A. Lawrence |
| author_sort | Hyunok Choi |
| collection | DOAJ |
| description | This review examines the causal investigation of preclinical development of childhood asthma using exposomic tools. We examine the current state of knowledge regarding early-life exposure to non-biogenic indoor air pollution and the developmental modulation of the immune system. We examine how metabolomics technologies could aid not only in the biomarker identification of a particular asthma phenotype, but also the mechanisms underlying the immunopathologic process. Within such a framework, we propose alternate components of exposomic investigation of asthma in which, the exposome represents a reiterative investigative process of targeted biomarker identification, validation through computational systems biology and physical sampling of environmental media. |
| first_indexed | 2024-12-12T23:25:56Z |
| format | Article |
| id | doaj.art-9b9f653e7a1548a0b41f949e5d3ec8be |
| institution | Directory Open Access Journal |
| issn | 2372-0344 2372-0352 |
| language | English |
| last_indexed | 2024-12-12T23:25:56Z |
| publishDate | 2015-02-01 |
| publisher | AIMS Press |
| record_format | Article |
| series | AIMS Environmental Science |
| spelling | doaj.art-9b9f653e7a1548a0b41f949e5d3ec8be2022-12-22T00:08:04ZengAIMS PressAIMS Environmental Science2372-03442372-03522015-02-01218710910.3934/environsci.2015.1.87Prenatal exposures and exposomics of asthmaHyunok Choi0Mark T. McAuley1David A. Lawrence2Departments of Environmental Health Sciences, Epidemiology, and Biostatistics, University at Albany, School of Public Health, One University Place, Rm 153, Rensselaer, NY 12144-3456, USAChemical Engineering Department, Faculty of Science and Engineering, Thornton Science Park, University of Chester, Chester, CH2 4NU, UKWadsworth Center, New York State Department of Health, Center for Medical Sciences, Rm 1155, 150 New Scotland Ave. Albany, NY 12201, USAThis review examines the causal investigation of preclinical development of childhood asthma using exposomic tools. We examine the current state of knowledge regarding early-life exposure to non-biogenic indoor air pollution and the developmental modulation of the immune system. We examine how metabolomics technologies could aid not only in the biomarker identification of a particular asthma phenotype, but also the mechanisms underlying the immunopathologic process. Within such a framework, we propose alternate components of exposomic investigation of asthma in which, the exposome represents a reiterative investigative process of targeted biomarker identification, validation through computational systems biology and physical sampling of environmental media.air pollutionprenatalearly-lifein uteroexposomeasthmaimmunemetabolomicsindoor |
| spellingShingle | Hyunok Choi Mark T. McAuley David A. Lawrence Prenatal exposures and exposomics of asthma AIMS Environmental Science air pollution prenatal early-life in utero exposome asthma immune metabolomics indoor |
| title | Prenatal exposures and exposomics of asthma |
| title_full | Prenatal exposures and exposomics of asthma |
| title_fullStr | Prenatal exposures and exposomics of asthma |
| title_full_unstemmed | Prenatal exposures and exposomics of asthma |
| title_short | Prenatal exposures and exposomics of asthma |
| title_sort | prenatal exposures and exposomics of asthma |
| topic | air pollution prenatal early-life in utero exposome asthma immune metabolomics indoor |
| work_keys_str_mv | AT hyunokchoi prenatalexposuresandexposomicsofasthma AT marktmcauley prenatalexposuresandexposomicsofasthma AT davidalawrence prenatalexposuresandexposomicsofasthma |