Abnormal gut microbiota and impaired incretin effect as a cause of type 2 diabetes mellitus
It has now been established that the intestinal microbiota (CM) is one of the 11 links in the pathogenesis of type 2 diabetes mellitus (DM2). Th e fact is that when the composition of BM is disrupted and the concentration of its active metabolites changes, the processes of synthesis and secretion of...
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| Format: | Article |
| Language: | English |
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State Budget Educational Institute of Higher Professional Education, Rostov State Medical University, Ministry Health of Russian Federation
2022-03-01
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| Series: | Медицинский вестник Юга России |
| Subjects: | |
| Online Access: | https://www.medicalherald.ru/jour/article/view/1463 |
| _version_ | 1811179486850318336 |
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| author | T. Y. Demidova K. G. Lobanova T. N. Korotkova L. D. Kharchilava |
| author_facet | T. Y. Demidova K. G. Lobanova T. N. Korotkova L. D. Kharchilava |
| author_sort | T. Y. Demidova |
| collection | DOAJ |
| description | It has now been established that the intestinal microbiota (CM) is one of the 11 links in the pathogenesis of type 2 diabetes mellitus (DM2). Th e fact is that when the composition of BM is disrupted and the concentration of its active metabolites changes, the processes of synthesis and secretion of incretin hormones are disrupted, the homeostasis of carbohydrates and fats in the body is disrupted, the processes of central regulation of appetite change, chronic infl ammation and insulin resistance of peripheral tissues develop. Th is review discusses possible ways of impairing the synthesis of incretin hormones and the incretin eff ect in patients with T2DM through the prism of BM and its active metabolites, and discusses possible ways of correcting the altered composition of BM with incretin drugs.A systematic literature search was carried out using the Scopus, PubMed, Web of Science databases. |
| first_indexed | 2024-04-11T06:35:04Z |
| format | Article |
| id | doaj.art-9b9f72eed03b4d0e92a19242bab6ba46 |
| institution | Directory Open Access Journal |
| issn | 2219-8075 2618-7876 |
| language | English |
| last_indexed | 2024-04-11T06:35:04Z |
| publishDate | 2022-03-01 |
| publisher | State Budget Educational Institute of Higher Professional Education, Rostov State Medical University, Ministry Health of Russian Federation |
| record_format | Article |
| series | Медицинский вестник Юга России |
| spelling | doaj.art-9b9f72eed03b4d0e92a19242bab6ba462022-12-22T04:39:51ZengState Budget Educational Institute of Higher Professional Education, Rostov State Medical University, Ministry Health of Russian FederationМедицинский вестник Юга России2219-80752618-78762022-03-01131244210.21886/2219-8075-2022-13-1-24-42837Abnormal gut microbiota and impaired incretin effect as a cause of type 2 diabetes mellitusT. Y. Demidova0K. G. Lobanova1T. N. Korotkova2L. D. Kharchilava3Pirogov Russian National Research Medical UniversityPirogov Russian National Research Medical UniversityFederal Research Center of Nutrition and BiotechnologyPirogov Russian National Research Medical UniversityIt has now been established that the intestinal microbiota (CM) is one of the 11 links in the pathogenesis of type 2 diabetes mellitus (DM2). Th e fact is that when the composition of BM is disrupted and the concentration of its active metabolites changes, the processes of synthesis and secretion of incretin hormones are disrupted, the homeostasis of carbohydrates and fats in the body is disrupted, the processes of central regulation of appetite change, chronic infl ammation and insulin resistance of peripheral tissues develop. Th is review discusses possible ways of impairing the synthesis of incretin hormones and the incretin eff ect in patients with T2DM through the prism of BM and its active metabolites, and discusses possible ways of correcting the altered composition of BM with incretin drugs.A systematic literature search was carried out using the Scopus, PubMed, Web of Science databases.https://www.medicalherald.ru/jour/article/view/1463gut microbiotaincretin eff ectglucagon-like peptide-1glucose-dependent insulinotropic peptidetype 2 diabetes mellitusreview |
| spellingShingle | T. Y. Demidova K. G. Lobanova T. N. Korotkova L. D. Kharchilava Abnormal gut microbiota and impaired incretin effect as a cause of type 2 diabetes mellitus Медицинский вестник Юга России gut microbiota incretin eff ect glucagon-like peptide-1 glucose-dependent insulinotropic peptide type 2 diabetes mellitus review |
| title | Abnormal gut microbiota and impaired incretin effect as a cause of type 2 diabetes mellitus |
| title_full | Abnormal gut microbiota and impaired incretin effect as a cause of type 2 diabetes mellitus |
| title_fullStr | Abnormal gut microbiota and impaired incretin effect as a cause of type 2 diabetes mellitus |
| title_full_unstemmed | Abnormal gut microbiota and impaired incretin effect as a cause of type 2 diabetes mellitus |
| title_short | Abnormal gut microbiota and impaired incretin effect as a cause of type 2 diabetes mellitus |
| title_sort | abnormal gut microbiota and impaired incretin effect as a cause of type 2 diabetes mellitus |
| topic | gut microbiota incretin eff ect glucagon-like peptide-1 glucose-dependent insulinotropic peptide type 2 diabetes mellitus review |
| url | https://www.medicalherald.ru/jour/article/view/1463 |
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