Genome-wide methylation and transcriptome of blood neutrophils reveal the roles of DNA methylation in affecting transcription of protein-coding genes and miRNAs in E. coli-infected mastitis cows

Genome-wide methylation and transcriptome of blood neutrophils reveal the roles of DNA methylation in affecting transcription of protein-coding genes and miRNAs in E. coli-infected mastitis cows

Abstract Background Neutrophils are the first effectors of inflammatory response triggered by mastitis infection, and are important defense cells against pathogenic Escherichia coli (E. coli). DNA methylation, as a critical epigenetic mechanism for regulating gene function, is involved in bovine mas...

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Bibliographic Details
Main Authors: Zhihua Ju, Qiang Jiang, Jinpeng Wang, Xiuge Wang, Chunhong Yang, Yan Sun, Yaran Zhang, Changfa Wang, Yaping Gao, Xiaochao Wei, Minghai Hou, Jinming Huang
Format: Article
Language:English
Published: BMC 2020-01-01
Series:BMC Genomics
Subjects:
Cows
E. coli mastitis
Neutrophils
DNA methylation
Expression pattern
miRNA
Online Access:https://doi.org/10.1186/s12864-020-6526-z

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