Small RNAs, spermatogenesis, and male infertility: a decade of retrospect
Abstract Small non-coding RNAs (sncRNAs), being the top regulators of gene expression, have been thoroughly studied in various biological systems, including the testis. Research over the last decade has generated significant evidence in support of the crucial roles of sncRNAs in male reproduction, p...
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| Format: | Article |
| Language: | English |
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BMC
2023-11-01
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| Series: | Reproductive Biology and Endocrinology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12958-023-01155-w |
| _version_ | 1797636630777954304 |
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| author | Meghali Joshi Shruti Sethi Poonam Mehta Anamika Kumari Singh Rajender |
| author_facet | Meghali Joshi Shruti Sethi Poonam Mehta Anamika Kumari Singh Rajender |
| author_sort | Meghali Joshi |
| collection | DOAJ |
| description | Abstract Small non-coding RNAs (sncRNAs), being the top regulators of gene expression, have been thoroughly studied in various biological systems, including the testis. Research over the last decade has generated significant evidence in support of the crucial roles of sncRNAs in male reproduction, particularly in the maintenance of primordial germ cells, meiosis, spermiogenesis, sperm fertility, and early post-fertilization development. The most commonly studied small RNAs in spermatogenesis are microRNAs (miRNAs), PIWI-interacting RNA (piRNA), small interfering RNA (siRNA), and transfer RNA-derived small RNAs (ts-RNAs). Small non-coding RNAs are crucial in regulating the dynamic, spatial, and temporal gene expression profiles in developing germ cells. A number of small RNAs, particularly miRNAs and tsRNAs, are loaded on spermatozoa during their epididymal maturation. With regard to their roles in fertility, miRNAs have been studied most often, followed by piRNAs and tsRNAs. Dysregulation of more than 100 miRNAs has been shown to correlate with infertility. piRNA and tsRNA dysregulations in infertility have been studied in only 3–5 studies. Sperm-borne small RNAs hold great potential to act as biomarkers of sperm quality and fertility. In this article, we review the role of small RNAs in spermatogenesis, their association with infertility, and their potential as biomarkers of sperm quality and fertility. |
| first_indexed | 2024-03-11T12:36:46Z |
| format | Article |
| id | doaj.art-9ba1276251ee4e08845f34c8cedcf8a1 |
| institution | Directory Open Access Journal |
| issn | 1477-7827 |
| language | English |
| last_indexed | 2024-03-11T12:36:46Z |
| publishDate | 2023-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Reproductive Biology and Endocrinology |
| spelling | doaj.art-9ba1276251ee4e08845f34c8cedcf8a12023-11-05T12:32:32ZengBMCReproductive Biology and Endocrinology1477-78272023-11-0121112410.1186/s12958-023-01155-wSmall RNAs, spermatogenesis, and male infertility: a decade of retrospectMeghali Joshi0Shruti Sethi1Poonam Mehta2Anamika Kumari3Singh Rajender4Division of Endocrinology, Central Drug Research InstituteDivision of Endocrinology, Central Drug Research InstituteDivision of Endocrinology, Central Drug Research InstituteDivision of Endocrinology, Central Drug Research InstituteDivision of Endocrinology, Central Drug Research InstituteAbstract Small non-coding RNAs (sncRNAs), being the top regulators of gene expression, have been thoroughly studied in various biological systems, including the testis. Research over the last decade has generated significant evidence in support of the crucial roles of sncRNAs in male reproduction, particularly in the maintenance of primordial germ cells, meiosis, spermiogenesis, sperm fertility, and early post-fertilization development. The most commonly studied small RNAs in spermatogenesis are microRNAs (miRNAs), PIWI-interacting RNA (piRNA), small interfering RNA (siRNA), and transfer RNA-derived small RNAs (ts-RNAs). Small non-coding RNAs are crucial in regulating the dynamic, spatial, and temporal gene expression profiles in developing germ cells. A number of small RNAs, particularly miRNAs and tsRNAs, are loaded on spermatozoa during their epididymal maturation. With regard to their roles in fertility, miRNAs have been studied most often, followed by piRNAs and tsRNAs. Dysregulation of more than 100 miRNAs has been shown to correlate with infertility. piRNA and tsRNA dysregulations in infertility have been studied in only 3–5 studies. Sperm-borne small RNAs hold great potential to act as biomarkers of sperm quality and fertility. In this article, we review the role of small RNAs in spermatogenesis, their association with infertility, and their potential as biomarkers of sperm quality and fertility.https://doi.org/10.1186/s12958-023-01155-wSpermatogenesismiRNASmall RNAsNon-coding RNApiRNAtsRNA |
| spellingShingle | Meghali Joshi Shruti Sethi Poonam Mehta Anamika Kumari Singh Rajender Small RNAs, spermatogenesis, and male infertility: a decade of retrospect Reproductive Biology and Endocrinology Spermatogenesis miRNA Small RNAs Non-coding RNA piRNA tsRNA |
| title | Small RNAs, spermatogenesis, and male infertility: a decade of retrospect |
| title_full | Small RNAs, spermatogenesis, and male infertility: a decade of retrospect |
| title_fullStr | Small RNAs, spermatogenesis, and male infertility: a decade of retrospect |
| title_full_unstemmed | Small RNAs, spermatogenesis, and male infertility: a decade of retrospect |
| title_short | Small RNAs, spermatogenesis, and male infertility: a decade of retrospect |
| title_sort | small rnas spermatogenesis and male infertility a decade of retrospect |
| topic | Spermatogenesis miRNA Small RNAs Non-coding RNA piRNA tsRNA |
| url | https://doi.org/10.1186/s12958-023-01155-w |
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