Development and application of a PBPK modeling strategy to support antimalarial drug development

Development and application of a PBPK modeling strategy to support antimalarial drug development

Abstract As part of a collaboration between Medicines for Malaria Venture (MMV), Certara UK and Monash University, physiologically‐based pharmacokinetic (PBPK) models were developed for 20 antimalarials, using data obtained from standardized in vitro assays and clinical studies within the literature...

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Bibliographic Details
Main Authors: Nada Abla, Eleanor Howgate, Karen Rowland‐Yeo, Maurice Dickins, Mackenzie C. Bergagnini‐Kolev, Kuan‐Fu Chen, Savannah McFeely, Jennifer J. Bonner, Laura G. A. Santos, Nathalie Gobeau, Howard Burt, Zoe Barter, Hannah M. Jones, David Wesche, Susan A. Charman, Jörg J. Möhrle, Jeremy N. Burrows, Lisa M. Almond
Format: Article
Language:English
Published: Wiley 2023-09-01
Series:CPT: Pharmacometrics & Systems Pharmacology
Online Access:https://doi.org/10.1002/psp4.13013

Internet

https://doi.org/10.1002/psp4.13013

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