Towards a Rapid-Turnaround Low-Depth Unbiased Metagenomics Sequencing Workflow on the Illumina Platforms

Towards a Rapid-Turnaround Low-Depth Unbiased Metagenomics Sequencing Workflow on the Illumina Platforms

Unbiased metagenomic sequencing is conceptually well-suited for first-line diagnosis as all known and unknown infectious entities can be detected, but costs, turnaround time and human background reads in complex biofluids, such as plasma, hinder widespread deployment. Separate preparations of DNA an...

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Bibliographic Details
Main Authors: Winston Lian Chye Koh, Si En Poh, Chun Kiat Lee, Tim Hon Man Chan, Gabriel Yan, Kiat Whye Kong, Lalita Lau, Wai Yip Thomas Lee, Clark Cheng, Shawn Hoon, Yiqi Seow
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Bioengineering
Subjects:
metagenomic sequencing
host depletion
DNA/RNA library preparation
liquid biopsy
infectious disease
Online Access:https://www.mdpi.com/2306-5354/10/5/520

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