Ceramide sensing by human SPT-ORMDL complex for establishing sphingolipid homeostasis

Ceramide sensing by human SPT-ORMDL complex for establishing sphingolipid homeostasis

Abstract The ORM/ORMDL family proteins function as regulatory subunits of the serine palmitoyltransferase (SPT) complex, which is the initiating and rate-limiting enzyme in sphingolipid biosynthesis. This complex is tightly regulated by cellular sphingolipid levels, but the sphingolipid sensing mech...

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Bibliographic Details
Main Authors:	Tian Xie, Peng Liu, Xinyue Wu, Feitong Dong, Zike Zhang, Jian Yue, Usha Mahawar, Faheem Farooq, Hisham Vohra, Qi Fang, Wenchen Liu, Binks W. Wattenberg, Xin Gong
Format:	Article
Language:	English
Published:	Nature Portfolio 2023-06-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-023-39274-y

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