Powerful Complex Immunoadjuvant Based on Synergistic Effect of Combined TLR4 and NOD2 Activation Significantly Enhances Magnitude of Humoral and Cellular Adaptive Immune Responses.

Powerful Complex Immunoadjuvant Based on Synergistic Effect of Combined TLR4 and NOD2 Activation Significantly Enhances Magnitude of Humoral and Cellular Adaptive Immune Responses.

Binding of pattern recognition receptors (PRRs) by pathogen-associated molecular patterns (PAMPs) activates innate immune responses and contributes to development of adaptive immunity. Simultaneous stimulation of different types of PRRs can have synergistic immunostimulatory effects resulting in enh...

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Bibliographic Details
Main Authors: Amir I Tukhvatulin, Alina S Dzharullaeva, Natalia M Tukhvatulina, Dmitry V Shcheblyakov, Maxim M Shmarov, Inna V Dolzhikova, Patricia Stanhope-Baker, Boris S Naroditsky, Andrei V Gudkov, Denis Y Logunov, Alexander L Gintsburg
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4871337?pdf=render

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