Salivary and Serum Interferon-Gamma/Interleukin-4 Ratio in Oral Lichen Planus Patients: A Systematic Review and Meta-Analysis
<i>Background and Objectives:</i> Interferon-gamma (IFN-γ)/interleukin-4 (IL-4) ratio may indicate a change in the immune response with a potential pathological effect presented in oral lichen planus (OLP) patients. Herein, this meta-analysis evaluated the role of serum and sali...
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MDPI AG
2019-06-01
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| Online Access: | https://www.mdpi.com/1010-660X/55/6/257 |
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| author | Hamid Reza Mozaffari Maryam Molavi Pia Lopez-Jornet Masoud Sadeghi Mohsen Safaei Mohammad Moslem Imani Roohollah Sharifi Hedaiat Moradpoor Amin Golshah Ladan Jamshidy |
| author_facet | Hamid Reza Mozaffari Maryam Molavi Pia Lopez-Jornet Masoud Sadeghi Mohsen Safaei Mohammad Moslem Imani Roohollah Sharifi Hedaiat Moradpoor Amin Golshah Ladan Jamshidy |
| author_sort | Hamid Reza Mozaffari |
| collection | DOAJ |
| description | <i>Background and Objectives:</i> Interferon-gamma (IFN-γ)/interleukin-4 (IL-4) ratio may indicate a change in the immune response with a potential pathological effect presented in oral lichen planus (OLP) patients. Herein, this meta-analysis evaluated the role of serum and salivary interferon-gamma/interleukin-4 ratio in the severity and development of OLP. <i>Materials and Methods:</i> The Scopus, Cochrane Library, PubMed, and Web of Science databases were systematically searched to retrieve the relevant studies published up from the database inception to March 2019. The crude mean difference (MD) and 95% confidence interval (CI) were calculated by RevMan 5.3 software using a random-effects model. A sensitivity analysis was performed on the results using the CMA 2.0 software. A total of 98 studies were retrieved from the databases, of which at last seven studies were included in this meta-analysis. <i>Results:</i> The findings showed that the pooled MDs of serum and salivary IFN-γ/IL-4 ratio were −0.22 (95% CI: −1.16, 0.72; <i>p</i> = 0.64) and 0.17 (95% CI: −1.50, 1.84; <i>p</i> = 0.84) in OLP patients compared to controls, respectively. In addition, the pooled MDs of serum and salivary IFN-γ/IL-4 ratio were −0.15 (95% CI: −0.53, 0.23; <i>p</i> = 0.43) and −0.39 (95% CI: −0.63, −0.15; <i>p</i> = 0.001) in patients with erythematous/ulcerative subtype compared to patients with reticular subtype, respectively. <i>Conclusions:</i> In conclusion, the results of meta-analysis demonstrated that serum and salivary IFN-γ/IL-4 ratio cannot play a major role in OLP development and severity. |
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| issn | 1010-660X |
| language | English |
| last_indexed | 2024-03-12T09:26:33Z |
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| spelling | doaj.art-9ba74b854f20485f978db584c01876252023-09-02T14:10:29ZengMDPI AGMedicina1010-660X2019-06-0155625710.3390/medicina55060257medicina55060257Salivary and Serum Interferon-Gamma/Interleukin-4 Ratio in Oral Lichen Planus Patients: A Systematic Review and Meta-AnalysisHamid Reza Mozaffari0Maryam Molavi1Pia Lopez-Jornet2Masoud Sadeghi3Mohsen Safaei4Mohammad Moslem Imani5Roohollah Sharifi6Hedaiat Moradpoor7Amin Golshah8Ladan Jamshidy9Department of Oral and Maxillofacial Medicine, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah 6713954658, IranStudents Research Committee, Kermanshah University of Medical Sciences, Kermanshah 6715847141, IranFacultad de Medicina y Odontologia Universidad de Murcia, Hospital Morales Meseguer, Clinica Odontologic Adv Marques Velez s/n, 30008 Murcia, SpainMedical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah 6714415185, IranOral and Dental Sciences Research Laboratory, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah 6713954658, IranDepartment of Orthodontics, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah 6713954658, IranDepartment of Endodontics, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah 6713954658, IranDepartment of Prosthodontics, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah 6713954658, IranDepartment of Orthodontics, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah 6713954658, IranDepartment of Prosthodontics, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah 6713954658, Iran<i>Background and Objectives:</i> Interferon-gamma (IFN-γ)/interleukin-4 (IL-4) ratio may indicate a change in the immune response with a potential pathological effect presented in oral lichen planus (OLP) patients. Herein, this meta-analysis evaluated the role of serum and salivary interferon-gamma/interleukin-4 ratio in the severity and development of OLP. <i>Materials and Methods:</i> The Scopus, Cochrane Library, PubMed, and Web of Science databases were systematically searched to retrieve the relevant studies published up from the database inception to March 2019. The crude mean difference (MD) and 95% confidence interval (CI) were calculated by RevMan 5.3 software using a random-effects model. A sensitivity analysis was performed on the results using the CMA 2.0 software. A total of 98 studies were retrieved from the databases, of which at last seven studies were included in this meta-analysis. <i>Results:</i> The findings showed that the pooled MDs of serum and salivary IFN-γ/IL-4 ratio were −0.22 (95% CI: −1.16, 0.72; <i>p</i> = 0.64) and 0.17 (95% CI: −1.50, 1.84; <i>p</i> = 0.84) in OLP patients compared to controls, respectively. In addition, the pooled MDs of serum and salivary IFN-γ/IL-4 ratio were −0.15 (95% CI: −0.53, 0.23; <i>p</i> = 0.43) and −0.39 (95% CI: −0.63, −0.15; <i>p</i> = 0.001) in patients with erythematous/ulcerative subtype compared to patients with reticular subtype, respectively. <i>Conclusions:</i> In conclusion, the results of meta-analysis demonstrated that serum and salivary IFN-γ/IL-4 ratio cannot play a major role in OLP development and severity.https://www.mdpi.com/1010-660X/55/6/257oral lichen planusratiointerferon-gammainterleukin-4meta-analysis |
| spellingShingle | Hamid Reza Mozaffari Maryam Molavi Pia Lopez-Jornet Masoud Sadeghi Mohsen Safaei Mohammad Moslem Imani Roohollah Sharifi Hedaiat Moradpoor Amin Golshah Ladan Jamshidy Salivary and Serum Interferon-Gamma/Interleukin-4 Ratio in Oral Lichen Planus Patients: A Systematic Review and Meta-Analysis Medicina oral lichen planus ratio interferon-gamma interleukin-4 meta-analysis |
| title | Salivary and Serum Interferon-Gamma/Interleukin-4 Ratio in Oral Lichen Planus Patients: A Systematic Review and Meta-Analysis |
| title_full | Salivary and Serum Interferon-Gamma/Interleukin-4 Ratio in Oral Lichen Planus Patients: A Systematic Review and Meta-Analysis |
| title_fullStr | Salivary and Serum Interferon-Gamma/Interleukin-4 Ratio in Oral Lichen Planus Patients: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Salivary and Serum Interferon-Gamma/Interleukin-4 Ratio in Oral Lichen Planus Patients: A Systematic Review and Meta-Analysis |
| title_short | Salivary and Serum Interferon-Gamma/Interleukin-4 Ratio in Oral Lichen Planus Patients: A Systematic Review and Meta-Analysis |
| title_sort | salivary and serum interferon gamma interleukin 4 ratio in oral lichen planus patients a systematic review and meta analysis |
| topic | oral lichen planus ratio interferon-gamma interleukin-4 meta-analysis |
| url | https://www.mdpi.com/1010-660X/55/6/257 |
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