The Association of Tau With Mitochondrial Dysfunction in Alzheimer's Disease
Increasing evidence suggests that abnormally hyperphosphorylated tau plays a vital role in the pathogenesis of Alzheimer's disease (AD). Mitochondrial dysfunction also has a recognized role in the pathophysiology of AD. In recent years, mitochondrial dysfunction has been strongly associated wit...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-03-01
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| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fnins.2018.00163/full |
| _version_ | 1819243113582952448 |
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| author | Ying Cheng Feng Bai |
| author_facet | Ying Cheng Feng Bai |
| author_sort | Ying Cheng |
| collection | DOAJ |
| description | Increasing evidence suggests that abnormally hyperphosphorylated tau plays a vital role in the pathogenesis of Alzheimer's disease (AD). Mitochondrial dysfunction also has a recognized role in the pathophysiology of AD. In recent years, mitochondrial dysfunction has been strongly associated with tau pathology in AD. Overexpression of hyperphosphorylated and aggregated tau appears to damage the axonal transport, leading to abnormal mitochondrial distribution. In addition, pathological tau impairs mitochondrial dynamics by regulating mitochondrial fission/fusion proteins, and further causes mitochondrial dysfunction and neuronal damage. Moreover, mitochondrial dysfunction is also involved in promoting tau pathology in AD. In this article, we evaluate the relationship between phosphorylated tau and mitochondrial dysfunction in AD. |
| first_indexed | 2024-12-23T14:50:32Z |
| format | Article |
| id | doaj.art-9ba8be611a16446da37f1bd1a50d0bb8 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-23T14:50:32Z |
| publishDate | 2018-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-9ba8be611a16446da37f1bd1a50d0bb82022-12-21T17:42:58ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2018-03-011210.3389/fnins.2018.00163320523The Association of Tau With Mitochondrial Dysfunction in Alzheimer's DiseaseYing Cheng0Feng Bai1Department of Neurology, Affiliated ZhongDa Hospital, School of Medicine, Southeast University, Nanjing, ChinaDepartment of Neurology, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, ChinaIncreasing evidence suggests that abnormally hyperphosphorylated tau plays a vital role in the pathogenesis of Alzheimer's disease (AD). Mitochondrial dysfunction also has a recognized role in the pathophysiology of AD. In recent years, mitochondrial dysfunction has been strongly associated with tau pathology in AD. Overexpression of hyperphosphorylated and aggregated tau appears to damage the axonal transport, leading to abnormal mitochondrial distribution. In addition, pathological tau impairs mitochondrial dynamics by regulating mitochondrial fission/fusion proteins, and further causes mitochondrial dysfunction and neuronal damage. Moreover, mitochondrial dysfunction is also involved in promoting tau pathology in AD. In this article, we evaluate the relationship between phosphorylated tau and mitochondrial dysfunction in AD.http://journal.frontiersin.org/article/10.3389/fnins.2018.00163/fullAlzheimer's diseasetaumitochondrial transportmitochondrial dynamicsmitochondrial dysfunction |
| spellingShingle | Ying Cheng Feng Bai The Association of Tau With Mitochondrial Dysfunction in Alzheimer's Disease Frontiers in Neuroscience Alzheimer's disease tau mitochondrial transport mitochondrial dynamics mitochondrial dysfunction |
| title | The Association of Tau With Mitochondrial Dysfunction in Alzheimer's Disease |
| title_full | The Association of Tau With Mitochondrial Dysfunction in Alzheimer's Disease |
| title_fullStr | The Association of Tau With Mitochondrial Dysfunction in Alzheimer's Disease |
| title_full_unstemmed | The Association of Tau With Mitochondrial Dysfunction in Alzheimer's Disease |
| title_short | The Association of Tau With Mitochondrial Dysfunction in Alzheimer's Disease |
| title_sort | association of tau with mitochondrial dysfunction in alzheimer s disease |
| topic | Alzheimer's disease tau mitochondrial transport mitochondrial dynamics mitochondrial dysfunction |
| url | http://journal.frontiersin.org/article/10.3389/fnins.2018.00163/full |
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