Aquaporin-4 cerebrospinal fluid levels are higher in neurodegenerative dementia: looking at glymphatic system dysregulation
Abstract Aquaporin-4 (AQP4) is a channel protein that plays a fundamental role in glymphatic system, a newly described pathway for fluid exchange in the central nervous system, as well as a central figure in a fascinating new theory for the pathophysiology of neurodegenerative diseases such as Alzhe...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-09-01
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| Series: | Alzheimer’s Research & Therapy |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13195-022-01077-6 |
| _version_ | 1818021594660864000 |
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| author | Andrea Arighi Marina Arcaro Giorgio Giulio Fumagalli Tiziana Carandini Anna Margherita Pietroboni Luca Sacchi Chiara Fenoglio Maria Serpente Federica Sorrentino Giovanni Isgrò Federico Turkheimer Elio Scarpini Daniela Galimberti |
| author_facet | Andrea Arighi Marina Arcaro Giorgio Giulio Fumagalli Tiziana Carandini Anna Margherita Pietroboni Luca Sacchi Chiara Fenoglio Maria Serpente Federica Sorrentino Giovanni Isgrò Federico Turkheimer Elio Scarpini Daniela Galimberti |
| author_sort | Andrea Arighi |
| collection | DOAJ |
| description | Abstract Aquaporin-4 (AQP4) is a channel protein that plays a fundamental role in glymphatic system, a newly described pathway for fluid exchange in the central nervous system, as well as a central figure in a fascinating new theory for the pathophysiology of neurodegenerative diseases such as Alzheimer’s disease (AD) and frontotemporal dementia (FTD). In this study, cerebrospinal fluid (CSF) concentration of AQP4, amyloid-β, total tau and P-tau were determined in 103 CSF samples from patients affected by neurodegenerative dementias (AD and FTD) or psychiatric diseases and 21 controls. Significantly higher levels of AQP4 were found in AD and FTD patients compared to subjects not affected by neurodegenerative diseases, and a significant, positive correlation between AQP4 and total tau levels was found. This evidence may pave the way for future studies focused on the role of this channel protein in the clinical assessment of the glymphatic function and degree of neurodegeneration. |
| first_indexed | 2024-04-14T08:20:16Z |
| format | Article |
| id | doaj.art-9ba949bf23884ea38e448450ec33ba25 |
| institution | Directory Open Access Journal |
| issn | 1758-9193 |
| language | English |
| last_indexed | 2024-04-14T08:20:16Z |
| publishDate | 2022-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Alzheimer’s Research & Therapy |
| spelling | doaj.art-9ba949bf23884ea38e448450ec33ba252022-12-22T02:04:14ZengBMCAlzheimer’s Research & Therapy1758-91932022-09-0114111010.1186/s13195-022-01077-6Aquaporin-4 cerebrospinal fluid levels are higher in neurodegenerative dementia: looking at glymphatic system dysregulationAndrea Arighi0Marina Arcaro1Giorgio Giulio Fumagalli2Tiziana Carandini3Anna Margherita Pietroboni4Luca Sacchi5Chiara Fenoglio6Maria Serpente7Federica Sorrentino8Giovanni Isgrò9Federico Turkheimer10Elio Scarpini11Daniela Galimberti12Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Neurodegenerative Disease UnitFondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Neurodegenerative Disease UnitFondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Neurodegenerative Disease UnitFondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Neurodegenerative Disease UnitFondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Neurodegenerative Disease UnitFondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Neurodegenerative Disease UnitUniversity of MilanFondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Neurodegenerative Disease UnitUniversity of MilanFondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Neurodegenerative Disease UnitDepartment of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King’s College LondonFondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Neurodegenerative Disease UnitFondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Neurodegenerative Disease UnitAbstract Aquaporin-4 (AQP4) is a channel protein that plays a fundamental role in glymphatic system, a newly described pathway for fluid exchange in the central nervous system, as well as a central figure in a fascinating new theory for the pathophysiology of neurodegenerative diseases such as Alzheimer’s disease (AD) and frontotemporal dementia (FTD). In this study, cerebrospinal fluid (CSF) concentration of AQP4, amyloid-β, total tau and P-tau were determined in 103 CSF samples from patients affected by neurodegenerative dementias (AD and FTD) or psychiatric diseases and 21 controls. Significantly higher levels of AQP4 were found in AD and FTD patients compared to subjects not affected by neurodegenerative diseases, and a significant, positive correlation between AQP4 and total tau levels was found. This evidence may pave the way for future studies focused on the role of this channel protein in the clinical assessment of the glymphatic function and degree of neurodegeneration.https://doi.org/10.1186/s13195-022-01077-6Glymphatic systemAquaporin 4Amyloid-βCerebrospinal fluidAlzheimer’s diseaseFrontotemporal dementia |
| spellingShingle | Andrea Arighi Marina Arcaro Giorgio Giulio Fumagalli Tiziana Carandini Anna Margherita Pietroboni Luca Sacchi Chiara Fenoglio Maria Serpente Federica Sorrentino Giovanni Isgrò Federico Turkheimer Elio Scarpini Daniela Galimberti Aquaporin-4 cerebrospinal fluid levels are higher in neurodegenerative dementia: looking at glymphatic system dysregulation Alzheimer’s Research & Therapy Glymphatic system Aquaporin 4 Amyloid-β Cerebrospinal fluid Alzheimer’s disease Frontotemporal dementia |
| title | Aquaporin-4 cerebrospinal fluid levels are higher in neurodegenerative dementia: looking at glymphatic system dysregulation |
| title_full | Aquaporin-4 cerebrospinal fluid levels are higher in neurodegenerative dementia: looking at glymphatic system dysregulation |
| title_fullStr | Aquaporin-4 cerebrospinal fluid levels are higher in neurodegenerative dementia: looking at glymphatic system dysregulation |
| title_full_unstemmed | Aquaporin-4 cerebrospinal fluid levels are higher in neurodegenerative dementia: looking at glymphatic system dysregulation |
| title_short | Aquaporin-4 cerebrospinal fluid levels are higher in neurodegenerative dementia: looking at glymphatic system dysregulation |
| title_sort | aquaporin 4 cerebrospinal fluid levels are higher in neurodegenerative dementia looking at glymphatic system dysregulation |
| topic | Glymphatic system Aquaporin 4 Amyloid-β Cerebrospinal fluid Alzheimer’s disease Frontotemporal dementia |
| url | https://doi.org/10.1186/s13195-022-01077-6 |
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