Aquaporin-4 cerebrospinal fluid levels are higher in neurodegenerative dementia: looking at glymphatic system dysregulation

Aquaporin-4 cerebrospinal fluid levels are higher in neurodegenerative dementia: looking at glymphatic system dysregulation

Abstract Aquaporin-4 (AQP4) is a channel protein that plays a fundamental role in glymphatic system, a newly described pathway for fluid exchange in the central nervous system, as well as a central figure in a fascinating new theory for the pathophysiology of neurodegenerative diseases such as Alzhe...

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Bibliographic Details
Main Authors: Andrea Arighi, Marina Arcaro, Giorgio Giulio Fumagalli, Tiziana Carandini, Anna Margherita Pietroboni, Luca Sacchi, Chiara Fenoglio, Maria Serpente, Federica Sorrentino, Giovanni Isgrò, Federico Turkheimer, Elio Scarpini, Daniela Galimberti
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Alzheimer’s Research & Therapy
Subjects:
Glymphatic system
Aquaporin 4
Amyloid-β
Cerebrospinal fluid
Alzheimer’s disease
Frontotemporal dementia
Online Access:https://doi.org/10.1186/s13195-022-01077-6

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