Epithelial-Mesenchymal Transition: A Fundamental Cellular and Microenvironmental Process in Benign and Malignant Prostate Pathologies
Epithelial-mesenchymal transition (EMT) is a crucial and fundamental mechanism in many cellular processes, beginning with embryogenesis via tissue remodulation and wound healing, and plays a vital role in tumorigenesis and metastasis formation. EMT is a complex process that involves many transcripti...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/12/2/418 |
| _version_ | 1797298837999583232 |
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| author | Aviv Philip Goncharov Nino Vashakidze Gvantsa Kharaishvili |
| author_facet | Aviv Philip Goncharov Nino Vashakidze Gvantsa Kharaishvili |
| author_sort | Aviv Philip Goncharov |
| collection | DOAJ |
| description | Epithelial-mesenchymal transition (EMT) is a crucial and fundamental mechanism in many cellular processes, beginning with embryogenesis via tissue remodulation and wound healing, and plays a vital role in tumorigenesis and metastasis formation. EMT is a complex process that involves many transcription factors and genes that enable the tumor cell to leave the primary location, invade the basement membrane, and send metastasis to other tissues. Moreover, it may help the tumor avoid the immune system and establish radioresistance and chemoresistance. It may also change the normal microenvironment, thus promoting other key factors for tumor survival, such as hypoxia-induced factor-1 (HIF-1) and promoting neoangiogenesis. In this review, we will focus mainly on the role of EMT in benign prostate disease and especially in the process of establishment of malignant prostate tumors, their invasiveness, and aggressive behavior. We will discuss relevant study methods for EMT evaluation and possible clinical implications. We will also introduce clinical trials conducted according to CONSORT 2010 that try to harness EMT properties in the form of circulating tumor cells to predict aggressive patterns of prostate cancer. This review will provide the most up-to-date information to establish a keen understanding of the cellular and microenvironmental processes for developing novel treatment lines by modifying or blocking the pathways. |
| first_indexed | 2024-03-07T22:40:52Z |
| format | Article |
| id | doaj.art-9bac854f56c94aba8b44f1d9884b3d3c |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-07T22:40:52Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-9bac854f56c94aba8b44f1d9884b3d3c2024-02-23T15:08:46ZengMDPI AGBiomedicines2227-90592024-02-0112241810.3390/biomedicines12020418Epithelial-Mesenchymal Transition: A Fundamental Cellular and Microenvironmental Process in Benign and Malignant Prostate PathologiesAviv Philip Goncharov0Nino Vashakidze1Gvantsa Kharaishvili2Department of Clinical and Molecular Pathology, Palacky University, University Hospital, 779 00 Olomouc, Czech RepublicDepartment of Clinical and Molecular Pathology, Palacky University, University Hospital, 779 00 Olomouc, Czech RepublicDepartment of Clinical and Molecular Pathology, Palacky University, University Hospital, 779 00 Olomouc, Czech RepublicEpithelial-mesenchymal transition (EMT) is a crucial and fundamental mechanism in many cellular processes, beginning with embryogenesis via tissue remodulation and wound healing, and plays a vital role in tumorigenesis and metastasis formation. EMT is a complex process that involves many transcription factors and genes that enable the tumor cell to leave the primary location, invade the basement membrane, and send metastasis to other tissues. Moreover, it may help the tumor avoid the immune system and establish radioresistance and chemoresistance. It may also change the normal microenvironment, thus promoting other key factors for tumor survival, such as hypoxia-induced factor-1 (HIF-1) and promoting neoangiogenesis. In this review, we will focus mainly on the role of EMT in benign prostate disease and especially in the process of establishment of malignant prostate tumors, their invasiveness, and aggressive behavior. We will discuss relevant study methods for EMT evaluation and possible clinical implications. We will also introduce clinical trials conducted according to CONSORT 2010 that try to harness EMT properties in the form of circulating tumor cells to predict aggressive patterns of prostate cancer. This review will provide the most up-to-date information to establish a keen understanding of the cellular and microenvironmental processes for developing novel treatment lines by modifying or blocking the pathways.https://www.mdpi.com/2227-9059/12/2/418epithelial-mesenchymal transitionEMTprostate cancerBPHtranscription factors |
| spellingShingle | Aviv Philip Goncharov Nino Vashakidze Gvantsa Kharaishvili Epithelial-Mesenchymal Transition: A Fundamental Cellular and Microenvironmental Process in Benign and Malignant Prostate Pathologies Biomedicines epithelial-mesenchymal transition EMT prostate cancer BPH transcription factors |
| title | Epithelial-Mesenchymal Transition: A Fundamental Cellular and Microenvironmental Process in Benign and Malignant Prostate Pathologies |
| title_full | Epithelial-Mesenchymal Transition: A Fundamental Cellular and Microenvironmental Process in Benign and Malignant Prostate Pathologies |
| title_fullStr | Epithelial-Mesenchymal Transition: A Fundamental Cellular and Microenvironmental Process in Benign and Malignant Prostate Pathologies |
| title_full_unstemmed | Epithelial-Mesenchymal Transition: A Fundamental Cellular and Microenvironmental Process in Benign and Malignant Prostate Pathologies |
| title_short | Epithelial-Mesenchymal Transition: A Fundamental Cellular and Microenvironmental Process in Benign and Malignant Prostate Pathologies |
| title_sort | epithelial mesenchymal transition a fundamental cellular and microenvironmental process in benign and malignant prostate pathologies |
| topic | epithelial-mesenchymal transition EMT prostate cancer BPH transcription factors |
| url | https://www.mdpi.com/2227-9059/12/2/418 |
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