Metabolic Effects of Elicitors on the Biosynthesis of Tropane Alkaloids in Medicinal Plants
Tropane alkaloids (TAs) are large secondary metabolite alkaloids that find extensive applications in the synthesis of antidotes, anesthetics, antiemetics, motion sickness drugs, and antispasmodics. The current production method primarily depends on extraction from medicinal plants of the Solanaceae...
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| Format: | Article |
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MDPI AG
2023-08-01
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| Series: | Plants |
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| Online Access: | https://www.mdpi.com/2223-7747/12/17/3050 |
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| author | Yuru Wen Yiran Liao Yueli Tang Hongbo Zhang Jiahui Zhang Zhihua Liao |
| author_facet | Yuru Wen Yiran Liao Yueli Tang Hongbo Zhang Jiahui Zhang Zhihua Liao |
| author_sort | Yuru Wen |
| collection | DOAJ |
| description | Tropane alkaloids (TAs) are large secondary metabolite alkaloids that find extensive applications in the synthesis of antidotes, anesthetics, antiemetics, motion sickness drugs, and antispasmodics. The current production method primarily depends on extraction from medicinal plants of the Solanaceae family. Elicitation, as a highly effective biotechnological approach, offers significant advantages in augmenting the synthesis of secondary metabolites. The advantages include its simplicity of operation, low cost, and reduced risk of contamination. This review focuses on the impact of elicitation on the biosynthesis of TAs from three aspects: single-elicitor treatment, multiple-elicitor treatment, and the combination of elicitation strategy with other strategies. Some potential reasons are also proposed. Plant hormones and growth regulators, such as jasmonic acid (JA), salicylic acid (SA), and their derivatives, have been extensively employed in the separate elicitation processes. In recent years, novel elicitors represented by magnetic nanoparticles have emerged as significant factors in the investigation of yield enhancement in TAs. This approach shows promising potential for further development. The current utilization of multi-elicitor treatment is constrained, primarily relying on the combination of only two elicitors for induction. Some of these combinations have been found to exhibit synergistic amplification effects. However, the underlying molecular mechanism responsible for this phenomenon remains largely unknown. The literature concerning the integration of elicitation strategy with other strategies is limited, and several research gaps require further investigation. In conclusion, the impact of various elicitors on the accumulation of TAs is well-documented. However, further research is necessary to effectively implement elicitation strategies in commercial production. This includes the development of stable bioreactors, the elucidation of regulatory mechanisms, and the identification of more potent elicitors. |
| first_indexed | 2024-03-10T23:15:36Z |
| format | Article |
| id | doaj.art-9bacc37efed54d9494e8384d35caaf46 |
| institution | Directory Open Access Journal |
| issn | 2223-7747 |
| language | English |
| last_indexed | 2024-03-10T23:15:36Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Plants |
| spelling | doaj.art-9bacc37efed54d9494e8384d35caaf462023-11-19T08:40:36ZengMDPI AGPlants2223-77472023-08-011217305010.3390/plants12173050Metabolic Effects of Elicitors on the Biosynthesis of Tropane Alkaloids in Medicinal PlantsYuru Wen0Yiran Liao1Yueli Tang2Hongbo Zhang3Jiahui Zhang4Zhihua Liao5Integrative Sciencce Center of Germplasm Creation in Western China (Chongqing) Science City & Southwest University, School of Life Sciences, Southwest University, Chongqing 400715, ChinaIntegrative Sciencce Center of Germplasm Creation in Western China (Chongqing) Science City & Southwest University, School of Life Sciences, Southwest University, Chongqing 400715, ChinaIntegrative Sciencce Center of Germplasm Creation in Western China (Chongqing) Science City & Southwest University, School of Life Sciences, Southwest University, Chongqing 400715, ChinaKey Laboratory of Synthetic Biology of Ministry of Agriculture and Rural Affairs, Tobacco Research Institute of Chinese Academy of Agricultural Sciences, Qingdao 266101, ChinaIntegrative Sciencce Center of Germplasm Creation in Western China (Chongqing) Science City & Southwest University, School of Life Sciences, Southwest University, Chongqing 400715, ChinaIntegrative Sciencce Center of Germplasm Creation in Western China (Chongqing) Science City & Southwest University, School of Life Sciences, Southwest University, Chongqing 400715, ChinaTropane alkaloids (TAs) are large secondary metabolite alkaloids that find extensive applications in the synthesis of antidotes, anesthetics, antiemetics, motion sickness drugs, and antispasmodics. The current production method primarily depends on extraction from medicinal plants of the Solanaceae family. Elicitation, as a highly effective biotechnological approach, offers significant advantages in augmenting the synthesis of secondary metabolites. The advantages include its simplicity of operation, low cost, and reduced risk of contamination. This review focuses on the impact of elicitation on the biosynthesis of TAs from three aspects: single-elicitor treatment, multiple-elicitor treatment, and the combination of elicitation strategy with other strategies. Some potential reasons are also proposed. Plant hormones and growth regulators, such as jasmonic acid (JA), salicylic acid (SA), and their derivatives, have been extensively employed in the separate elicitation processes. In recent years, novel elicitors represented by magnetic nanoparticles have emerged as significant factors in the investigation of yield enhancement in TAs. This approach shows promising potential for further development. The current utilization of multi-elicitor treatment is constrained, primarily relying on the combination of only two elicitors for induction. Some of these combinations have been found to exhibit synergistic amplification effects. However, the underlying molecular mechanism responsible for this phenomenon remains largely unknown. The literature concerning the integration of elicitation strategy with other strategies is limited, and several research gaps require further investigation. In conclusion, the impact of various elicitors on the accumulation of TAs is well-documented. However, further research is necessary to effectively implement elicitation strategies in commercial production. This includes the development of stable bioreactors, the elucidation of regulatory mechanisms, and the identification of more potent elicitors.https://www.mdpi.com/2223-7747/12/17/3050elicitationhyoscyaminemedicinal plantsproductionscopolaminetropane alkaloids |
| spellingShingle | Yuru Wen Yiran Liao Yueli Tang Hongbo Zhang Jiahui Zhang Zhihua Liao Metabolic Effects of Elicitors on the Biosynthesis of Tropane Alkaloids in Medicinal Plants Plants elicitation hyoscyamine medicinal plants production scopolamine tropane alkaloids |
| title | Metabolic Effects of Elicitors on the Biosynthesis of Tropane Alkaloids in Medicinal Plants |
| title_full | Metabolic Effects of Elicitors on the Biosynthesis of Tropane Alkaloids in Medicinal Plants |
| title_fullStr | Metabolic Effects of Elicitors on the Biosynthesis of Tropane Alkaloids in Medicinal Plants |
| title_full_unstemmed | Metabolic Effects of Elicitors on the Biosynthesis of Tropane Alkaloids in Medicinal Plants |
| title_short | Metabolic Effects of Elicitors on the Biosynthesis of Tropane Alkaloids in Medicinal Plants |
| title_sort | metabolic effects of elicitors on the biosynthesis of tropane alkaloids in medicinal plants |
| topic | elicitation hyoscyamine medicinal plants production scopolamine tropane alkaloids |
| url | https://www.mdpi.com/2223-7747/12/17/3050 |
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