Cortical Gray Matter Injury in Encephalopathy of Prematurity: Link to Neurodevelopmental Disorders
Preterm-born infants frequently suffer from an array of neurological damage, collectively termed encephalopathy of prematurity (EoP). They also have an increased risk of presenting with a neurodevelopmental disorder (e.g., autism spectrum disorder; attention deficit hyperactivity disorder) later in...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-07-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fneur.2020.00575/full |
| _version_ | 1818684429418102784 |
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| author | Bobbi Fleiss Bobbi Fleiss Bobbi Fleiss Bobbi Fleiss Pierre Gressens Pierre Gressens Pierre Gressens Helen B. Stolp Helen B. Stolp |
| author_facet | Bobbi Fleiss Bobbi Fleiss Bobbi Fleiss Bobbi Fleiss Pierre Gressens Pierre Gressens Pierre Gressens Helen B. Stolp Helen B. Stolp |
| author_sort | Bobbi Fleiss |
| collection | DOAJ |
| description | Preterm-born infants frequently suffer from an array of neurological damage, collectively termed encephalopathy of prematurity (EoP). They also have an increased risk of presenting with a neurodevelopmental disorder (e.g., autism spectrum disorder; attention deficit hyperactivity disorder) later in life. It is hypothesized that it is the gray matter injury to the cortex, in addition to white matter injury, in EoP that is responsible for the altered behavior and cognition in these individuals. However, although it is established that gray matter injury occurs in infants following preterm birth, the exact nature of these changes is not fully elucidated. Here we will review the current state of knowledge in this field, amalgamating data from both clinical and preclinical studies. This will be placed in the context of normal processes of developmental biology and the known pathophysiology of neurodevelopmental disorders. Novel diagnostic and therapeutic tactics required integration of this information so that in the future we can combine mechanism-based approaches with patient stratification to ensure the most efficacious and cost-effective clinical practice. |
| first_indexed | 2024-12-17T10:50:29Z |
| format | Article |
| id | doaj.art-9bb058368cf54ad7904b5e2e907572d6 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-17T10:50:29Z |
| publishDate | 2020-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-9bb058368cf54ad7904b5e2e907572d62022-12-21T21:52:00ZengFrontiers Media S.A.Frontiers in Neurology1664-22952020-07-011110.3389/fneur.2020.00575549930Cortical Gray Matter Injury in Encephalopathy of Prematurity: Link to Neurodevelopmental DisordersBobbi Fleiss0Bobbi Fleiss1Bobbi Fleiss2Bobbi Fleiss3Pierre Gressens4Pierre Gressens5Pierre Gressens6Helen B. Stolp7Helen B. Stolp8School of Health and Biomedical Sciences, RMIT University, Bundoora, VIC, AustraliaUniversité de Paris, NeuroDiderot, Inserm, Paris, FrancePremUP, Paris, FranceCentre for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United KingdomUniversité de Paris, NeuroDiderot, Inserm, Paris, FrancePremUP, Paris, FranceCentre for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United KingdomCentre for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United KingdomComparative Biomedical Sciences, Royal Veterinary College, London, United KingdomPreterm-born infants frequently suffer from an array of neurological damage, collectively termed encephalopathy of prematurity (EoP). They also have an increased risk of presenting with a neurodevelopmental disorder (e.g., autism spectrum disorder; attention deficit hyperactivity disorder) later in life. It is hypothesized that it is the gray matter injury to the cortex, in addition to white matter injury, in EoP that is responsible for the altered behavior and cognition in these individuals. However, although it is established that gray matter injury occurs in infants following preterm birth, the exact nature of these changes is not fully elucidated. Here we will review the current state of knowledge in this field, amalgamating data from both clinical and preclinical studies. This will be placed in the context of normal processes of developmental biology and the known pathophysiology of neurodevelopmental disorders. Novel diagnostic and therapeutic tactics required integration of this information so that in the future we can combine mechanism-based approaches with patient stratification to ensure the most efficacious and cost-effective clinical practice.https://www.frontiersin.org/article/10.3389/fneur.2020.00575/fullpretermbrain injurydevelopmentinflammationsynaptopathyMRI |
| spellingShingle | Bobbi Fleiss Bobbi Fleiss Bobbi Fleiss Bobbi Fleiss Pierre Gressens Pierre Gressens Pierre Gressens Helen B. Stolp Helen B. Stolp Cortical Gray Matter Injury in Encephalopathy of Prematurity: Link to Neurodevelopmental Disorders Frontiers in Neurology preterm brain injury development inflammation synaptopathy MRI |
| title | Cortical Gray Matter Injury in Encephalopathy of Prematurity: Link to Neurodevelopmental Disorders |
| title_full | Cortical Gray Matter Injury in Encephalopathy of Prematurity: Link to Neurodevelopmental Disorders |
| title_fullStr | Cortical Gray Matter Injury in Encephalopathy of Prematurity: Link to Neurodevelopmental Disorders |
| title_full_unstemmed | Cortical Gray Matter Injury in Encephalopathy of Prematurity: Link to Neurodevelopmental Disorders |
| title_short | Cortical Gray Matter Injury in Encephalopathy of Prematurity: Link to Neurodevelopmental Disorders |
| title_sort | cortical gray matter injury in encephalopathy of prematurity link to neurodevelopmental disorders |
| topic | preterm brain injury development inflammation synaptopathy MRI |
| url | https://www.frontiersin.org/article/10.3389/fneur.2020.00575/full |
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