Human P2X7 Receptor Causes Cycle Arrest in RPMI-8226 Myeloma Cells to Alter the Interaction with Osteoblasts and Osteoclasts

Human P2X7 Receptor Causes Cycle Arrest in RPMI-8226 Myeloma Cells to Alter the Interaction with Osteoblasts and Osteoclasts

Multiple myeloma is a malignant expansion of plasma cells and aggressively affects bone health. We show that P2X7 receptor altered myeloma growth, which affects primary bone cells in vitro. Expression on six human myeloma cell lines confirmed the heterogeneity associated with P2X7 receptor. Pharmaco...

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Bibliographic Details
Main Authors: Ankita Agrawal, Lars S. Kruse, Annette J. Vangsted, Alison Gartland, Niklas R. Jørgensen
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Cells
Subjects:
P2X7 receptor
myeloma
osteoblasts
osteoclasts
Online Access:https://www.mdpi.com/2073-4409/9/11/2341

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