Deployment of a retinal determination gene network drives directed cell migration in the sea urchin embryo
Gene regulatory networks (GRNs) provide a systems-level orchestration of an organism's genome encoded anatomy. As biological networks are revealed, they continue to answer many questions including knowledge of how GRNs control morphogenetic movements and how GRNs evolve. The migration of the sm...
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2015-09-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/08827 |
| _version_ | 1828375352063295488 |
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| author | Megan L Martik David R McClay |
| author_facet | Megan L Martik David R McClay |
| author_sort | Megan L Martik |
| collection | DOAJ |
| description | Gene regulatory networks (GRNs) provide a systems-level orchestration of an organism's genome encoded anatomy. As biological networks are revealed, they continue to answer many questions including knowledge of how GRNs control morphogenetic movements and how GRNs evolve. The migration of the small micromeres to the coelomic pouches in the sea urchin embryo provides an exceptional model for understanding the genomic regulatory control of morphogenesis. An assay using the robust homing potential of these cells reveals a ‘coherent feed-forward’ transcriptional subcircuit composed of Pax6, Six3, Six1/2, Eya, and Dach1 that is responsible for the directed homing mechanism of these multipotent progenitors. The linkages of that circuit are strikingly similar to a circuit involved in retinal specification in Drosophila suggesting that systems-level tasks can be highly conserved even though the tasks drive unrelated processes in different animals. |
| first_indexed | 2024-04-14T07:45:22Z |
| format | Article |
| id | doaj.art-9bb23ec318fa40f0afbc88a5d6eca61c |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-14T07:45:22Z |
| publishDate | 2015-09-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-9bb23ec318fa40f0afbc88a5d6eca61c2022-12-22T02:05:21ZengeLife Sciences Publications LtdeLife2050-084X2015-09-01410.7554/eLife.08827Deployment of a retinal determination gene network drives directed cell migration in the sea urchin embryoMegan L Martik0David R McClay1University Program in Genetics and Genomics, Duke University, Durham, United StatesDepartment of Biology, Duke University, Durham, United StatesGene regulatory networks (GRNs) provide a systems-level orchestration of an organism's genome encoded anatomy. As biological networks are revealed, they continue to answer many questions including knowledge of how GRNs control morphogenetic movements and how GRNs evolve. The migration of the small micromeres to the coelomic pouches in the sea urchin embryo provides an exceptional model for understanding the genomic regulatory control of morphogenesis. An assay using the robust homing potential of these cells reveals a ‘coherent feed-forward’ transcriptional subcircuit composed of Pax6, Six3, Six1/2, Eya, and Dach1 that is responsible for the directed homing mechanism of these multipotent progenitors. The linkages of that circuit are strikingly similar to a circuit involved in retinal specification in Drosophila suggesting that systems-level tasks can be highly conserved even though the tasks drive unrelated processes in different animals.https://elifesciences.org/articles/08827sea urchinsmall micromeresdirected cell migrationgene regulatory network |
| spellingShingle | Megan L Martik David R McClay Deployment of a retinal determination gene network drives directed cell migration in the sea urchin embryo eLife sea urchin small micromeres directed cell migration gene regulatory network |
| title | Deployment of a retinal determination gene network drives directed cell migration in the sea urchin embryo |
| title_full | Deployment of a retinal determination gene network drives directed cell migration in the sea urchin embryo |
| title_fullStr | Deployment of a retinal determination gene network drives directed cell migration in the sea urchin embryo |
| title_full_unstemmed | Deployment of a retinal determination gene network drives directed cell migration in the sea urchin embryo |
| title_short | Deployment of a retinal determination gene network drives directed cell migration in the sea urchin embryo |
| title_sort | deployment of a retinal determination gene network drives directed cell migration in the sea urchin embryo |
| topic | sea urchin small micromeres directed cell migration gene regulatory network |
| url | https://elifesciences.org/articles/08827 |
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