Defective resection at DNA double-strand breaks leads to de novo telomere formation and enhances gene targeting.

Defective resection at DNA double-strand breaks leads to de novo telomere formation and enhances gene targeting.

The formation of single-stranded DNA (ssDNA) at double-strand break (DSB) ends is essential in repair by homologous recombination and is mediated by DNA helicases and nucleases. Here we estimated the length of ssDNA generated during DSB repair and analyzed the consequences of elimination of processi...

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Bibliographic Details
Main Authors: Woo-Hyun Chung, Zhu Zhu, Alma Papusha, Anna Malkova, Grzegorz Ira
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-05-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC2869328?pdf=render

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