The Role of Oxytocin in Cardiovascular Protection
The beneficial effects of oxytocin on infarct size and functional recovery of the ischemic reperfused heart are well documented. The mechanisms for this cardioprotection are not well defined. Evidence indicates that oxytocin treatment improves cardiac work, reduces apoptosis and inflammation, and in...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-08-01
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| Series: | Frontiers in Psychology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fpsyg.2020.02139/full |
| _version_ | 1818529755442446336 |
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| author | Marek Jankowski Marek Jankowski Tom L. Broderick Jolanta Gutkowska Jolanta Gutkowska |
| author_facet | Marek Jankowski Marek Jankowski Tom L. Broderick Jolanta Gutkowska Jolanta Gutkowska |
| author_sort | Marek Jankowski |
| collection | DOAJ |
| description | The beneficial effects of oxytocin on infarct size and functional recovery of the ischemic reperfused heart are well documented. The mechanisms for this cardioprotection are not well defined. Evidence indicates that oxytocin treatment improves cardiac work, reduces apoptosis and inflammation, and increases scar vascularization. Oxytocin-mediated cytoprotection involves the production of cGMP stimulated by local release of atrial natriuretic peptide and synthesis of nitric oxide. Treatment with oxytocin reduces the expression of proinflammatory cytokines and reduces immune cell infiltration. Oxytocin also stimulates differentiation stem cells to cardiomyocyte lineages as well as generation of endothelial and smooth muscle cells, promoting angiogenesis. The beneficial actions of oxytocin may include the increase in glucose uptake by cardiomyocytes, reduction in cardiomyocyte hypertrophy, decrease in oxidative stress, and mitochondrial protection of several cell types. In cardiac and cellular models of ischemia and reperfusion, acute administration of oxytocin at the onset of reperfusion enhances cardiomyocyte viability and function by activating Pi3K and Akt phosphorylation and downstream cellular signaling. Reperfusion injury salvage kinase and signal transducer and activator of transcription proteins cardioprotective pathways are involved. Oxytocin is cardioprotective by reducing the inflammatory response and improving cardiovascular and metabolic function. Because of its pleiotropic nature, this peptide demonstrates a clear potential for the treatment of cardiovascular pathologies. In this review, we discuss the possible cellular mechanisms of action of oxytocin involved in cardioprotection. |
| first_indexed | 2024-12-11T17:11:00Z |
| format | Article |
| id | doaj.art-9bb5c602a4d44bc881e1fbc70afc72d5 |
| institution | Directory Open Access Journal |
| issn | 1664-1078 |
| language | English |
| last_indexed | 2024-12-11T17:11:00Z |
| publishDate | 2020-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychology |
| spelling | doaj.art-9bb5c602a4d44bc881e1fbc70afc72d52022-12-22T00:57:31ZengFrontiers Media S.A.Frontiers in Psychology1664-10782020-08-011110.3389/fpsyg.2020.02139516048The Role of Oxytocin in Cardiovascular ProtectionMarek Jankowski0Marek Jankowski1Tom L. Broderick2Jolanta Gutkowska3Jolanta Gutkowska4Cardiovascular Biochemistry Laboratory, University of Montreal Hospital Centre, Montreal, QC, CanadaDepartment of Medicine, University of Montreal, Montreal, QC, CanadaLaboratory of Diabetes and Exercise Metabolism, Department of Physiology, College of Graduate Studies, Midwestern University, Glendale, AZ, United StatesCardiovascular Biochemistry Laboratory, University of Montreal Hospital Centre, Montreal, QC, CanadaDepartment of Medicine, University of Montreal, Montreal, QC, CanadaThe beneficial effects of oxytocin on infarct size and functional recovery of the ischemic reperfused heart are well documented. The mechanisms for this cardioprotection are not well defined. Evidence indicates that oxytocin treatment improves cardiac work, reduces apoptosis and inflammation, and increases scar vascularization. Oxytocin-mediated cytoprotection involves the production of cGMP stimulated by local release of atrial natriuretic peptide and synthesis of nitric oxide. Treatment with oxytocin reduces the expression of proinflammatory cytokines and reduces immune cell infiltration. Oxytocin also stimulates differentiation stem cells to cardiomyocyte lineages as well as generation of endothelial and smooth muscle cells, promoting angiogenesis. The beneficial actions of oxytocin may include the increase in glucose uptake by cardiomyocytes, reduction in cardiomyocyte hypertrophy, decrease in oxidative stress, and mitochondrial protection of several cell types. In cardiac and cellular models of ischemia and reperfusion, acute administration of oxytocin at the onset of reperfusion enhances cardiomyocyte viability and function by activating Pi3K and Akt phosphorylation and downstream cellular signaling. Reperfusion injury salvage kinase and signal transducer and activator of transcription proteins cardioprotective pathways are involved. Oxytocin is cardioprotective by reducing the inflammatory response and improving cardiovascular and metabolic function. Because of its pleiotropic nature, this peptide demonstrates a clear potential for the treatment of cardiovascular pathologies. In this review, we discuss the possible cellular mechanisms of action of oxytocin involved in cardioprotection.https://www.frontiersin.org/article/10.3389/fpsyg.2020.02139/fulloxytocinoxytocin—therapeutic useheartatrial natriuretic peptidecardiomyocyte |
| spellingShingle | Marek Jankowski Marek Jankowski Tom L. Broderick Jolanta Gutkowska Jolanta Gutkowska The Role of Oxytocin in Cardiovascular Protection Frontiers in Psychology oxytocin oxytocin—therapeutic use heart atrial natriuretic peptide cardiomyocyte |
| title | The Role of Oxytocin in Cardiovascular Protection |
| title_full | The Role of Oxytocin in Cardiovascular Protection |
| title_fullStr | The Role of Oxytocin in Cardiovascular Protection |
| title_full_unstemmed | The Role of Oxytocin in Cardiovascular Protection |
| title_short | The Role of Oxytocin in Cardiovascular Protection |
| title_sort | role of oxytocin in cardiovascular protection |
| topic | oxytocin oxytocin—therapeutic use heart atrial natriuretic peptide cardiomyocyte |
| url | https://www.frontiersin.org/article/10.3389/fpsyg.2020.02139/full |
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