Gut bacteria, endocannabinoid system, and marijuana addiction: Novel therapeutic implications
Gut bacteria plays a leading role in the pharmacological actions of both synthetic and natural product derived drugs. Their interactions are complex and bidirectional. This complexity with psychotropic phyto-compounds like delta-9-tetrahydrocannabinol (∆9-THC) (source: cannabis) has been found for m...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-03-01
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| Series: | Health Sciences Review |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772632023000703 |
| _version_ | 1797397496022958080 |
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| author | Kishore Kumar Pinapati Sree Vidya Mohd Faiz Khan Debabrata Mandal Sugato Banerjee |
| author_facet | Kishore Kumar Pinapati Sree Vidya Mohd Faiz Khan Debabrata Mandal Sugato Banerjee |
| author_sort | Kishore Kumar Pinapati |
| collection | DOAJ |
| description | Gut bacteria plays a leading role in the pharmacological actions of both synthetic and natural product derived drugs. Their interactions are complex and bidirectional. This complexity with psychotropic phyto-compounds like delta-9-tetrahydrocannabinol (∆9-THC) (source: cannabis) has been found for modulating various brain functions including anxiety, depression, and cognition through an intricate cell-signaling network known as endocannabinoid system (ECS). This is a prominent neuromodulatory system that defines the host's health and disease. As a habit-forming weed, cannabis is associated with severe neuropsychiatric complications upon withdrawal. This is due to the dysregulation of monoamines (particularly dopamine and GABA) in the mesocorticolimbic circuit and hypothalamic-pituitary-adrenal axis. No notable pharmacotherapies are found for the treatment of cannabis dependence. Here, we postulate the connections between gut bacteria, CNS, ECS, and marijuana dependence, which would be an insight to overcome marijuana withdrawal symptoms. |
| first_indexed | 2024-03-09T01:11:51Z |
| format | Article |
| id | doaj.art-9bb5f23dca1f4fadb15235a164684651 |
| institution | Directory Open Access Journal |
| issn | 2772-6320 |
| language | English |
| last_indexed | 2024-03-09T01:11:51Z |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Health Sciences Review |
| spelling | doaj.art-9bb5f23dca1f4fadb15235a1646846512023-12-11T04:17:46ZengElsevierHealth Sciences Review2772-63202024-03-0110100144Gut bacteria, endocannabinoid system, and marijuana addiction: Novel therapeutic implicationsKishore Kumar Pinapati0Sree Vidya1Mohd Faiz Khan2Debabrata Mandal3Sugato Banerjee4Department of Biotechnology, National Institute of Pharmaceutical Education and Research Raebareli (NIPER-Raebareli), Bijnor, Lucknow, Uttar Pradesh 226002, IndiaDepartment of Biotechnology, Vignan's Foundation for Science, Technology, and Research (Deemed to be University), Vadlamudi, Guntur, Andhra Pradesh 522213, IndiaDepartment of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research Kolkata (NIPER-Kolkata), Maniktala main road, Kolkata, West Bengal 700054, IndiaDepartment of Biotechnology, National Institute of Pharmaceutical Education and Research Hajipur (NIPER-Hajipur), Industrial area, Hajipur, Vaishali, Bihar 844102, IndiaDepartment of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research Kolkata (NIPER-Kolkata), Maniktala main road, Kolkata, West Bengal 700054, India; Corresponding author.Gut bacteria plays a leading role in the pharmacological actions of both synthetic and natural product derived drugs. Their interactions are complex and bidirectional. This complexity with psychotropic phyto-compounds like delta-9-tetrahydrocannabinol (∆9-THC) (source: cannabis) has been found for modulating various brain functions including anxiety, depression, and cognition through an intricate cell-signaling network known as endocannabinoid system (ECS). This is a prominent neuromodulatory system that defines the host's health and disease. As a habit-forming weed, cannabis is associated with severe neuropsychiatric complications upon withdrawal. This is due to the dysregulation of monoamines (particularly dopamine and GABA) in the mesocorticolimbic circuit and hypothalamic-pituitary-adrenal axis. No notable pharmacotherapies are found for the treatment of cannabis dependence. Here, we postulate the connections between gut bacteria, CNS, ECS, and marijuana dependence, which would be an insight to overcome marijuana withdrawal symptoms.http://www.sciencedirect.com/science/article/pii/S2772632023000703CannabisAddictionEndocannabinoid systemMicrobiota-gut-brain-axisDysbiosisProbiotics |
| spellingShingle | Kishore Kumar Pinapati Sree Vidya Mohd Faiz Khan Debabrata Mandal Sugato Banerjee Gut bacteria, endocannabinoid system, and marijuana addiction: Novel therapeutic implications Health Sciences Review Cannabis Addiction Endocannabinoid system Microbiota-gut-brain-axis Dysbiosis Probiotics |
| title | Gut bacteria, endocannabinoid system, and marijuana addiction: Novel therapeutic implications |
| title_full | Gut bacteria, endocannabinoid system, and marijuana addiction: Novel therapeutic implications |
| title_fullStr | Gut bacteria, endocannabinoid system, and marijuana addiction: Novel therapeutic implications |
| title_full_unstemmed | Gut bacteria, endocannabinoid system, and marijuana addiction: Novel therapeutic implications |
| title_short | Gut bacteria, endocannabinoid system, and marijuana addiction: Novel therapeutic implications |
| title_sort | gut bacteria endocannabinoid system and marijuana addiction novel therapeutic implications |
| topic | Cannabis Addiction Endocannabinoid system Microbiota-gut-brain-axis Dysbiosis Probiotics |
| url | http://www.sciencedirect.com/science/article/pii/S2772632023000703 |
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