Serum total periostin is an independent marker of overall survival in bone metastases of lung adenocarcinoma
More than 35% of lung adenocarcinoma patients have bone metastases at diagnosis and have a poor survival. Periostin, a carboxylated matrix protein, mediates lung cancer cell dissemination by promoting epithelial-mesenchymal transition, and is involved in bone response to mechanical stress and bone f...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2021-08-01
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| Series: | Journal of Bone Oncology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S221213742100018X |
| _version_ | 1818366680310480896 |
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| author | E Massy JC. Rousseau M. Gueye E. Bonnelye M. Brevet L. Chambard M. Duruisseaux O. Borel C. Roger R. Guelminger J.B. Pialat E. Gineyts L. Bouazza M. Millet JM. Maury P. Clézardin N. Girard Cyrille B. Confavreux |
| author_facet | E Massy JC. Rousseau M. Gueye E. Bonnelye M. Brevet L. Chambard M. Duruisseaux O. Borel C. Roger R. Guelminger J.B. Pialat E. Gineyts L. Bouazza M. Millet JM. Maury P. Clézardin N. Girard Cyrille B. Confavreux |
| author_sort | E Massy |
| collection | DOAJ |
| description | More than 35% of lung adenocarcinoma patients have bone metastases at diagnosis and have a poor survival. Periostin, a carboxylated matrix protein, mediates lung cancer cell dissemination by promoting epithelial-mesenchymal transition, and is involved in bone response to mechanical stress and bone formation regulation. This suggests that periostin may be used as a biomarker to predict survival in lung cancer patients.Serum periostin was assessed at diagnosis in a prospective cohort of 133 patients with lung adenocarcinoma of all stages. Patients were divided into localized and bone metastatic groups. Both groups were matched to healthy controls. Survival analysis and Cox proportional hazards models were conducted in the total population and in bone metastatic group.The median serum periostin level was higher in bone metastatic (n = 67; median: 1752 pmol/L) than in the localized group (n = 66; 861 pmol/L; p < 0.0001). Patients with high periostin (>median) had a poorer overall survival in the whole population (33.3 weeks vs. NR; p < 0.0001) and the bone metastatic group (24.4 vs. 66.1 weeks; p < 0.001). In multivariate analysis, patients with high periostin had increased risk of death (HR = 2.09, 95%CI [1.06–4.13]; p = 0.03). This was also found in the bone metastatic group (HR = 3.62, 95%CI [1.74–7.52]; p = 0.0005). Immunohistochemistry on bone metastasis biopsies showed periostin expression in the bone matrix and nuclear and cytoplasmic staining in cancer cells.Serum periostin was an independent survival biomarker in all-stage and in bone metastatic lung adenocarcinoma patients. IHC data suggest that periostin might be induced in cancer cells in bone metastatic niche in addition to bone microenvironment expression. |
| first_indexed | 2024-12-13T22:40:00Z |
| format | Article |
| id | doaj.art-9bb65a5859be43dea045ded725c674fb |
| institution | Directory Open Access Journal |
| issn | 2212-1374 |
| language | English |
| last_indexed | 2024-12-13T22:40:00Z |
| publishDate | 2021-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Bone Oncology |
| spelling | doaj.art-9bb65a5859be43dea045ded725c674fb2022-12-21T23:28:52ZengElsevierJournal of Bone Oncology2212-13742021-08-0129100364Serum total periostin is an independent marker of overall survival in bone metastases of lung adenocarcinomaE Massy0JC. Rousseau1M. Gueye2E. Bonnelye3M. Brevet4L. Chambard5M. Duruisseaux6O. Borel7C. Roger8R. Guelminger9J.B. Pialat10E. Gineyts11L. Bouazza12M. Millet13JM. Maury14P. Clézardin15N. Girard16Cyrille B. Confavreux17INSERM UMR 1033-LYOS, Lyon, France; Université de Lyon, France; Centre Expert des Métastases Osseuses (CEMOS) – Service de Rhumatologie, Centre Hospitalier Lyon-Sud, Hospices Civils de Lyon, Pierre-Bénite, FranceINSERM UMR 1033-LYOS, Lyon, FranceCentre Expert des Métastases Osseuses (CEMOS) – Service de Rhumatologie, Centre Hospitalier Lyon-Sud, Hospices Civils de Lyon, Pierre-Bénite, FranceINSERM UMR 1033-LYOS, Lyon, France; Université de Lyon, FranceUniversité de Lyon, France; Anatomie pathologique, Hospices Civils de Lyon, Lyon, FranceCentre Expert des Métastases Osseuses (CEMOS) – Service de Rhumatologie, Centre Hospitalier Lyon-Sud, Hospices Civils de Lyon, Pierre-Bénite, FranceUniversité de Lyon, France; Service d’Oncologie Thoracique, Hôpital Louis Pradel, Hospices Civils de Lyon, Lyon, FranceCNRS ERL 6001/ INSERM U1232-Institut de Cancérologie de l’Ouest-Université de Nantes, FranceINSERM UMR 1033-LYOS, Lyon, France; Biochimie centre hospitalier Lyon sud, INSERM UMR 1033 – Hospices Civils de Lyon, Lyon, FranceService d’Oncologie Thoracique, Hôpital Louis Pradel, Hospices Civils de Lyon, Lyon, FranceService de Radiologie, Centre Hospitalier Lyon-Sud, Hospices Civils de Lyon, Pierre-Bénite, FranceINSERM UMR 1033-LYOS, Lyon, FranceINSERM UMR 1033-LYOS, Lyon, FranceINSERM UMR 1033-LYOS, Lyon, FranceChirurgie thoracique, Hôpital Louis Pradel, Hospices Civils de Lyon, Lyon, FranceINSERM UMR 1033-LYOS, Lyon, France; Université de Lyon, FrancePneumologie, Institut du thorax Curie-Montsouris, Paris, FranceINSERM UMR 1033-LYOS, Lyon, France; Université de Lyon, France; Centre Expert des Métastases Osseuses (CEMOS) – Service de Rhumatologie, Centre Hospitalier Lyon-Sud, Hospices Civils de Lyon, Pierre-Bénite, France; Corresponding author at: Service de Rhumatologie Hôpital Lyon Sud, 165 chemin du Grand Revoyet, 69310 Pierre Bénite, France.More than 35% of lung adenocarcinoma patients have bone metastases at diagnosis and have a poor survival. Periostin, a carboxylated matrix protein, mediates lung cancer cell dissemination by promoting epithelial-mesenchymal transition, and is involved in bone response to mechanical stress and bone formation regulation. This suggests that periostin may be used as a biomarker to predict survival in lung cancer patients.Serum periostin was assessed at diagnosis in a prospective cohort of 133 patients with lung adenocarcinoma of all stages. Patients were divided into localized and bone metastatic groups. Both groups were matched to healthy controls. Survival analysis and Cox proportional hazards models were conducted in the total population and in bone metastatic group.The median serum periostin level was higher in bone metastatic (n = 67; median: 1752 pmol/L) than in the localized group (n = 66; 861 pmol/L; p < 0.0001). Patients with high periostin (>median) had a poorer overall survival in the whole population (33.3 weeks vs. NR; p < 0.0001) and the bone metastatic group (24.4 vs. 66.1 weeks; p < 0.001). In multivariate analysis, patients with high periostin had increased risk of death (HR = 2.09, 95%CI [1.06–4.13]; p = 0.03). This was also found in the bone metastatic group (HR = 3.62, 95%CI [1.74–7.52]; p = 0.0005). Immunohistochemistry on bone metastasis biopsies showed periostin expression in the bone matrix and nuclear and cytoplasmic staining in cancer cells.Serum periostin was an independent survival biomarker in all-stage and in bone metastatic lung adenocarcinoma patients. IHC data suggest that periostin might be induced in cancer cells in bone metastatic niche in addition to bone microenvironment expression.http://www.sciencedirect.com/science/article/pii/S221213742100018XBone metastasisPeriostinLung cancerSerum biomarkerSurvival |
| spellingShingle | E Massy JC. Rousseau M. Gueye E. Bonnelye M. Brevet L. Chambard M. Duruisseaux O. Borel C. Roger R. Guelminger J.B. Pialat E. Gineyts L. Bouazza M. Millet JM. Maury P. Clézardin N. Girard Cyrille B. Confavreux Serum total periostin is an independent marker of overall survival in bone metastases of lung adenocarcinoma Journal of Bone Oncology Bone metastasis Periostin Lung cancer Serum biomarker Survival |
| title | Serum total periostin is an independent marker of overall survival in bone metastases of lung adenocarcinoma |
| title_full | Serum total periostin is an independent marker of overall survival in bone metastases of lung adenocarcinoma |
| title_fullStr | Serum total periostin is an independent marker of overall survival in bone metastases of lung adenocarcinoma |
| title_full_unstemmed | Serum total periostin is an independent marker of overall survival in bone metastases of lung adenocarcinoma |
| title_short | Serum total periostin is an independent marker of overall survival in bone metastases of lung adenocarcinoma |
| title_sort | serum total periostin is an independent marker of overall survival in bone metastases of lung adenocarcinoma |
| topic | Bone metastasis Periostin Lung cancer Serum biomarker Survival |
| url | http://www.sciencedirect.com/science/article/pii/S221213742100018X |
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