Self‐Degradable Nanogels Reshape Immunosuppressive Tumor Microenvironment via Drug Repurposing Strategy to Reactivate Cytotoxic CD8+ T Cells

Self‐Degradable Nanogels Reshape Immunosuppressive Tumor Microenvironment via Drug Repurposing Strategy to Reactivate Cytotoxic CD8+ T Cells

Abstract Intratumoral CD8+ T cells are crucial for effective cancer immunotherapy, but an immunosuppressive tumor microenvironment (TME) contributes to dysfunction and insufficient infiltration. Drug repurposing has successfully led to new discoveries among existing clinical drugs for use as immune...

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Bibliographic Details
Main Authors: Hao Tian, Wenxi Li, Guohao Wang, Ye Tian, Jie Yan, Songtao Zhou, Xinying Yu, Bei Li, Yunlu Dai
Format: Article
Language:English
Published: Wiley 2023-07-01
Series:Advanced Science
Subjects:
CD8+ T cells
drug repurposing
immunosuppressive tumor microenvironment
self‐degradable nanogels
Online Access:https://doi.org/10.1002/advs.202301661

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