p53 Dimers associate with a head-to-tail response element to repress cyclin B transcription.

p53 Dimers associate with a head-to-tail response element to repress cyclin B transcription.

DNA damage induced by the topoisomerase I inhibitor SN38 activates cell cycle checkpoints which promote cell cycle arrest. This arrest can be abrogated in p53-defective cells by the Chk1 inhibitor 7-hydroxystaurosporine (UCN-01). Previously, we compared p53 wild-type MCF10A cells with derivatives wh...

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Príomhchruthaitheoirí: Robert Lipski, Daniel J Lippincott, Brittany C Durden, Anne R Kaplan, Hilary E Keiser, Jung-Ho Park, Aime A Levesque
Formáid: Alt
Teanga:English
Foilsithe / Cruthaithe: Public Library of Science (PLoS) 2012-01-01
Sraith:PLoS ONE
Rochtain ar líne:http://europepmc.org/articles/PMC3414442?pdf=render

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http://europepmc.org/articles/PMC3414442?pdf=render

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