COVID−19, Anti-NMDA Receptor Encephalitis and MicroRNA

The coronavirus disease 2019 (COVID-19) pandemic has had an enormous impact on the world, affecting people’s lifestyle, economy, and livelihood. Recently, with the development of vaccines, the number of infected cases has decreased. Many case reports have revealed that COVID-19 may induce other seri...

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Main Author: Hsiuying Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Immunology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.825103/full
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author Hsiuying Wang
author_facet Hsiuying Wang
author_sort Hsiuying Wang
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description The coronavirus disease 2019 (COVID-19) pandemic has had an enormous impact on the world, affecting people’s lifestyle, economy, and livelihood. Recently, with the development of vaccines, the number of infected cases has decreased. Many case reports have revealed that COVID-19 may induce other serious comorbidities such as anti-N-methyl-d-aspartate (anti-NMDA) receptor encephalitis. Anti-NMDA receptor encephalitis is an acute autoimmune disease that occurs more commonly in women than in men. To explore the association between COVID-19 and anti-NMDA receptor encephalitis, the microRNA (miRNA) biomarkers of COVID-19, anti-NMDA receptor encephalitis, and other related diseases from the literature are reviewed; then on the basis of these miRNA biomarkers, the relationship between COVID-19 and anti-NMDA receptor encephalitis is discussed. miRNAs are small non-coding RNAs that play important roles in cell differentiation, development, cell-cycle regulation, and apoptosis. miRNAs have been used as biological biomarkers for many diseases. The results in this study reveal that the relationship between anti-NMDA receptor encephalitis and COVID-19 infection or COVID-19 vaccination cannot be excluded; however, the risk that COVID-19 triggers the anti-NMDA receptor encephalitis is not high.
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spelling doaj.art-9bb9dff9340e410ca6e8bc1988444e9d2022-12-22T02:37:39ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-03-011310.3389/fimmu.2022.825103825103COVID−19, Anti-NMDA Receptor Encephalitis and MicroRNAHsiuying WangThe coronavirus disease 2019 (COVID-19) pandemic has had an enormous impact on the world, affecting people’s lifestyle, economy, and livelihood. Recently, with the development of vaccines, the number of infected cases has decreased. Many case reports have revealed that COVID-19 may induce other serious comorbidities such as anti-N-methyl-d-aspartate (anti-NMDA) receptor encephalitis. Anti-NMDA receptor encephalitis is an acute autoimmune disease that occurs more commonly in women than in men. To explore the association between COVID-19 and anti-NMDA receptor encephalitis, the microRNA (miRNA) biomarkers of COVID-19, anti-NMDA receptor encephalitis, and other related diseases from the literature are reviewed; then on the basis of these miRNA biomarkers, the relationship between COVID-19 and anti-NMDA receptor encephalitis is discussed. miRNAs are small non-coding RNAs that play important roles in cell differentiation, development, cell-cycle regulation, and apoptosis. miRNAs have been used as biological biomarkers for many diseases. The results in this study reveal that the relationship between anti-NMDA receptor encephalitis and COVID-19 infection or COVID-19 vaccination cannot be excluded; however, the risk that COVID-19 triggers the anti-NMDA receptor encephalitis is not high.https://www.frontiersin.org/articles/10.3389/fimmu.2022.825103/fullanti-NMDA receptor encephalitisbiomarkersCOVID−19microRNAvaccine
spellingShingle Hsiuying Wang
COVID−19, Anti-NMDA Receptor Encephalitis and MicroRNA
Frontiers in Immunology
anti-NMDA receptor encephalitis
biomarkers
COVID−19
microRNA
vaccine
title COVID−19, Anti-NMDA Receptor Encephalitis and MicroRNA
title_full COVID−19, Anti-NMDA Receptor Encephalitis and MicroRNA
title_fullStr COVID−19, Anti-NMDA Receptor Encephalitis and MicroRNA
title_full_unstemmed COVID−19, Anti-NMDA Receptor Encephalitis and MicroRNA
title_short COVID−19, Anti-NMDA Receptor Encephalitis and MicroRNA
title_sort covid 19 anti nmda receptor encephalitis and microrna
topic anti-NMDA receptor encephalitis
biomarkers
COVID−19
microRNA
vaccine
url https://www.frontiersin.org/articles/10.3389/fimmu.2022.825103/full
work_keys_str_mv AT hsiuyingwang covid19antinmdareceptorencephalitisandmicrorna