Noninvasive classification of liver disease in asymptomatic and oligosymptomatic male alcoholics
The predominant type of liver alteration in asymptomatic or oligosymptomatic chronic male alcoholics (N = 169) admitted to a psychiatric hospital for detoxification was classified by two independent methods: liver palpation and multiple quadratic discriminant analysis (QDA), the latter applied to tw...
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Divulgação Científica
2003-10-01
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| Series: | Brazilian Journal of Medical and Biological Research |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003001000013 |
| _version_ | 1811253999722037248 |
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| author | P. Borini R.C. Guimarães |
| author_facet | P. Borini R.C. Guimarães |
| author_sort | P. Borini |
| collection | DOAJ |
| description | The predominant type of liver alteration in asymptomatic or oligosymptomatic chronic male alcoholics (N = 169) admitted to a psychiatric hospital for detoxification was classified by two independent methods: liver palpation and multiple quadratic discriminant analysis (QDA), the latter applied to two parameters reported by the patient (duration of alcoholism and daily amount ingested) and to the data obtained from eight biochemical blood determinations (total bilirubin, alkaline phosphatase, glycemia, potassium, aspartate aminotransferase, albumin, globulin, and sodium). All 11 soft and sensitive, and 13 firm and sensitive livers formed fully concordant groups as determined by QDA. Among the 22 soft and not sensitive livers, 95% were concordant by QDA grouping. Concordance rates were low (55%) in the 73 firm and not sensitive livers, and intermediate (76%) in the 50 not palpable livers. Prediction of the liver palpation characteristics by QDA was 95% correct for the firm and not sensitive livers and moderate for the other groups. On a preliminary basis, the variables considered to be most informative by QDA were the two anamnestic data and bilirubin levels, followed by alkaline phosphatase, glycemia and potassium, and then by aspartate aminotransferase and albumin. We conclude that, when biopsies would be too costly or potentially injurious to the patients to varying extents, clinical data could be considered valid to guide patient care, at least in the three groups (soft, not sensitive; soft, sensitive; firm, sensitive livers) in which the two noninvasive procedures were highly concordant in the present study. |
| first_indexed | 2024-04-12T16:59:48Z |
| format | Article |
| id | doaj.art-9bba0b8bab8246ab9b1de979ba8bb97f |
| institution | Directory Open Access Journal |
| issn | 0100-879X 1414-431X |
| language | English |
| last_indexed | 2024-04-12T16:59:48Z |
| publishDate | 2003-10-01 |
| publisher | Associação Brasileira de Divulgação Científica |
| record_format | Article |
| series | Brazilian Journal of Medical and Biological Research |
| spelling | doaj.art-9bba0b8bab8246ab9b1de979ba8bb97f2022-12-22T03:24:06ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research0100-879X1414-431X2003-10-0136101367137310.1590/S0100-879X2003001000013Noninvasive classification of liver disease in asymptomatic and oligosymptomatic male alcoholicsP. BoriniR.C. GuimarãesThe predominant type of liver alteration in asymptomatic or oligosymptomatic chronic male alcoholics (N = 169) admitted to a psychiatric hospital for detoxification was classified by two independent methods: liver palpation and multiple quadratic discriminant analysis (QDA), the latter applied to two parameters reported by the patient (duration of alcoholism and daily amount ingested) and to the data obtained from eight biochemical blood determinations (total bilirubin, alkaline phosphatase, glycemia, potassium, aspartate aminotransferase, albumin, globulin, and sodium). All 11 soft and sensitive, and 13 firm and sensitive livers formed fully concordant groups as determined by QDA. Among the 22 soft and not sensitive livers, 95% were concordant by QDA grouping. Concordance rates were low (55%) in the 73 firm and not sensitive livers, and intermediate (76%) in the 50 not palpable livers. Prediction of the liver palpation characteristics by QDA was 95% correct for the firm and not sensitive livers and moderate for the other groups. On a preliminary basis, the variables considered to be most informative by QDA were the two anamnestic data and bilirubin levels, followed by alkaline phosphatase, glycemia and potassium, and then by aspartate aminotransferase and albumin. We conclude that, when biopsies would be too costly or potentially injurious to the patients to varying extents, clinical data could be considered valid to guide patient care, at least in the three groups (soft, not sensitive; soft, sensitive; firm, sensitive livers) in which the two noninvasive procedures were highly concordant in the present study.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003001000013AlcoholismHepatopathyNoninvasive classificationLiver palpationLaboratory examsDiscriminant analysis |
| spellingShingle | P. Borini R.C. Guimarães Noninvasive classification of liver disease in asymptomatic and oligosymptomatic male alcoholics Brazilian Journal of Medical and Biological Research Alcoholism Hepatopathy Noninvasive classification Liver palpation Laboratory exams Discriminant analysis |
| title | Noninvasive classification of liver disease in asymptomatic and oligosymptomatic male alcoholics |
| title_full | Noninvasive classification of liver disease in asymptomatic and oligosymptomatic male alcoholics |
| title_fullStr | Noninvasive classification of liver disease in asymptomatic and oligosymptomatic male alcoholics |
| title_full_unstemmed | Noninvasive classification of liver disease in asymptomatic and oligosymptomatic male alcoholics |
| title_short | Noninvasive classification of liver disease in asymptomatic and oligosymptomatic male alcoholics |
| title_sort | noninvasive classification of liver disease in asymptomatic and oligosymptomatic male alcoholics |
| topic | Alcoholism Hepatopathy Noninvasive classification Liver palpation Laboratory exams Discriminant analysis |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003001000013 |
| work_keys_str_mv | AT pborini noninvasiveclassificationofliverdiseaseinasymptomaticandoligosymptomaticmalealcoholics AT rcguimaraes noninvasiveclassificationofliverdiseaseinasymptomaticandoligosymptomaticmalealcoholics |