Systematic Analysis of Composition, Interfacial Performance and Effects of Pulmonary Surfactant Preparations on Cellular Uptake and Cytotoxicity of Aerosolized Nanomaterials

Systematic Analysis of Composition, Interfacial Performance and Effects of Pulmonary Surfactant Preparations on Cellular Uptake and Cytotoxicity of Aerosolized Nanomaterials

The interplay of particles with pulmonary surfactant, a lipid‐protein material pivotal for lung function, is hypothesized as a key factor that has not been routinely considered in the current in vitro models when determining the fate of inhaled nanomaterials. To explain its influence on cellular upt...

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Bibliographic Details
Main Authors: Benedikt Huck, Alberto Hidalgo, Franziska Waldow, Dominik Schwudke, Karoline I. Gaede, Claus Feldmann, Patrick Carius, Chiara Autilio, Jesus Pérez-Gil, Konrad Schwarzkopf, Xabier Murgia, Brigitta Loretz, Claus-Michael Lehr
Format: Article
Language:English
Published: Wiley-VCH 2021-12-01
Series:Small Science
Subjects:
air–blood barrier
air–liquid interfaces
cellular lung models
drug delivery
lipidomics
nanotoxicities
Online Access:https://doi.org/10.1002/smsc.202100067

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