Six Transmembrane Epithelial Antigen 1 as a Prognostic Biomarker in Carcinomas: A Meta-Analysis
Background: Six transmembrane epithelial antigen 1 (STEAP1) is aberrantly expressed in cancers and could therefore be a potential biomarker. This study examined the connection between STEAP1 expression and clinical features/prognosis in cancer patients. Methods: Several databases were comprehensivel...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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IMR Press
2023-11-01
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| Series: | Frontiers in Bioscience-Landmark |
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| Online Access: | https://www.imrpress.com/journal/FBL/28/11/10.31083/j.fbl2811280 |
| _version_ | 1797400735718047744 |
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| author | Shidi Zhao Huan Chen Yan Zhou Quanfang Wang Xiao Liang Na Yang Li Yan Jin Yang |
| author_facet | Shidi Zhao Huan Chen Yan Zhou Quanfang Wang Xiao Liang Na Yang Li Yan Jin Yang |
| author_sort | Shidi Zhao |
| collection | DOAJ |
| description | Background: Six transmembrane epithelial antigen 1 (STEAP1) is aberrantly expressed in cancers and could therefore be a potential biomarker. This study examined the connection between STEAP1 expression and clinical features/prognosis in cancer patients. Methods: Several databases were comprehensively searched for related published studies. The combination of hazard ratios (HRs), odd ratios (ORs), and 95% confidence intervals (95% CIs) was used to assess the role of STEAP1. The Cancer Genome Atlas (TCGA) dataset was used to estimate the prognostic value of STEAP1 in multiple cancer types, and several biological behaviors related to STEAP1 were evaluated by CancerSEA. Results: Searches of electronic databases revealed 7 relevant trials with 765 patients. A significant connection was found between high STEAP1 expression and worse overall survival amongst cancer patients (HR = 1.87, 95% CI: 1.49–2.34, p < 0.001). In addition, a strong correlation was found between high STEAP1 expression and the occurrence of lymph node metastases (OR = 3.19, 95% CI: 1.26–8.09, p < 0.001). Analysis of TCGA datasets verified that a higher level of STEAP1 expression is linked with reduced survival in many kinds of cancer. At the single cell level, STEAP1 expression was correlated with some tumor biological behaviors, such as angiogenesis, quiescence, and stemness. Conclusions: STEAP1 could regulate various biological functions in tumors and predict prognosis as a novel biomarker in a number of cancer types. |
| first_indexed | 2024-03-09T01:58:51Z |
| format | Article |
| id | doaj.art-9bc164b1fc23445a9509569607ad23cd |
| institution | Directory Open Access Journal |
| issn | 2768-6701 |
| language | English |
| last_indexed | 2024-03-09T01:58:51Z |
| publishDate | 2023-11-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Frontiers in Bioscience-Landmark |
| spelling | doaj.art-9bc164b1fc23445a9509569607ad23cd2023-12-08T07:49:21ZengIMR PressFrontiers in Bioscience-Landmark2768-67012023-11-01281128010.31083/j.fbl2811280S2768-6701(23)01082-1Six Transmembrane Epithelial Antigen 1 as a Prognostic Biomarker in Carcinomas: A Meta-AnalysisShidi Zhao0Huan Chen1Yan Zhou2Quanfang Wang3Xiao Liang4Na Yang5Li Yan6Jin Yang7Cancer Center, The First Affiliated Hospital of Xi’an Jiaotong University, 710061 Xi’an, Shaanxi, ChinaDepartment of Respiratory & Critical Care Medicine, The First Affiliated Hospital of Xi’an Jiaotong University, 710061 Xi’an, Shaanxi, ChinaCancer Center, The First Affiliated Hospital of Xi’an Jiaotong University, 710061 Xi’an, Shaanxi, ChinaDepartment of Pharmacy, The First Affiliated Hospital of Xi’an Jiaotong University, 710061 Xi’an, Shaanxi, ChinaCancer Center, The First Affiliated Hospital of Xi’an Jiaotong University, 710061 Xi’an, Shaanxi, ChinaCancer Center, The First Affiliated Hospital of Xi’an Jiaotong University, 710061 Xi’an, Shaanxi, ChinaCancer Center, The First Affiliated Hospital of Xi’an Jiaotong University, 710061 Xi’an, Shaanxi, ChinaCancer Center, The First Affiliated Hospital of Xi’an Jiaotong University, 710061 Xi’an, Shaanxi, ChinaBackground: Six transmembrane epithelial antigen 1 (STEAP1) is aberrantly expressed in cancers and could therefore be a potential biomarker. This study examined the connection between STEAP1 expression and clinical features/prognosis in cancer patients. Methods: Several databases were comprehensively searched for related published studies. The combination of hazard ratios (HRs), odd ratios (ORs), and 95% confidence intervals (95% CIs) was used to assess the role of STEAP1. The Cancer Genome Atlas (TCGA) dataset was used to estimate the prognostic value of STEAP1 in multiple cancer types, and several biological behaviors related to STEAP1 were evaluated by CancerSEA. Results: Searches of electronic databases revealed 7 relevant trials with 765 patients. A significant connection was found between high STEAP1 expression and worse overall survival amongst cancer patients (HR = 1.87, 95% CI: 1.49–2.34, p < 0.001). In addition, a strong correlation was found between high STEAP1 expression and the occurrence of lymph node metastases (OR = 3.19, 95% CI: 1.26–8.09, p < 0.001). Analysis of TCGA datasets verified that a higher level of STEAP1 expression is linked with reduced survival in many kinds of cancer. At the single cell level, STEAP1 expression was correlated with some tumor biological behaviors, such as angiogenesis, quiescence, and stemness. Conclusions: STEAP1 could regulate various biological functions in tumors and predict prognosis as a novel biomarker in a number of cancer types.https://www.imrpress.com/journal/FBL/28/11/10.31083/j.fbl2811280steap1cancerbiomarkerprognosismeta-analysis |
| spellingShingle | Shidi Zhao Huan Chen Yan Zhou Quanfang Wang Xiao Liang Na Yang Li Yan Jin Yang Six Transmembrane Epithelial Antigen 1 as a Prognostic Biomarker in Carcinomas: A Meta-Analysis Frontiers in Bioscience-Landmark steap1 cancer biomarker prognosis meta-analysis |
| title | Six Transmembrane Epithelial Antigen 1 as a Prognostic Biomarker in Carcinomas: A Meta-Analysis |
| title_full | Six Transmembrane Epithelial Antigen 1 as a Prognostic Biomarker in Carcinomas: A Meta-Analysis |
| title_fullStr | Six Transmembrane Epithelial Antigen 1 as a Prognostic Biomarker in Carcinomas: A Meta-Analysis |
| title_full_unstemmed | Six Transmembrane Epithelial Antigen 1 as a Prognostic Biomarker in Carcinomas: A Meta-Analysis |
| title_short | Six Transmembrane Epithelial Antigen 1 as a Prognostic Biomarker in Carcinomas: A Meta-Analysis |
| title_sort | six transmembrane epithelial antigen 1 as a prognostic biomarker in carcinomas a meta analysis |
| topic | steap1 cancer biomarker prognosis meta-analysis |
| url | https://www.imrpress.com/journal/FBL/28/11/10.31083/j.fbl2811280 |
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