Can the Methotrexate Therapy Prevent the Development of Uveitis in Patients with Juvenile Idiopathic Arthritis: Results of a Retrospective Study
Background: Uveitis is one of the most common extra-articular manifestations of juvenile idiopathic arthritis (JIA). Currently, the possibility of reducing the risk of uveitis in children with JIA by using methotrexate has been studied.Objective: Our aim was to analyze the results of treatment of ch...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
"Paediatrician" Publishers LLC
2015-09-01
|
| Series: | Вопросы современной педиатрии |
| Subjects: | |
| Online Access: | https://vsp.spr-journal.ru/jour/article/view/1077 |
| _version_ | 1797700460549767168 |
|---|---|
| author | M. M. Kostik E. V. Gaydar M. F. Dubko V. V. Masalova L. S. Snegireva I. A. Chikova E. A. Isupova T. N. Nikitina E. D. Serogodskaya O. V. Kalashnikova A. Ravelli V. G. Chasnyk |
| author_facet | M. M. Kostik E. V. Gaydar M. F. Dubko V. V. Masalova L. S. Snegireva I. A. Chikova E. A. Isupova T. N. Nikitina E. D. Serogodskaya O. V. Kalashnikova A. Ravelli V. G. Chasnyk |
| author_sort | M. M. Kostik |
| collection | DOAJ |
| description | Background: Uveitis is one of the most common extra-articular manifestations of juvenile idiopathic arthritis (JIA). Currently, the possibility of reducing the risk of uveitis in children with JIA by using methotrexate has been studied.Objective: Our aim was to analyze the results of treatment of children with JIA by studying the relation between the use of methotrexate and the risk of uveitis.Methods: A retrospective uncontrolled study. The case histories of patients with JIA who were treated for at least 2 years after the onset of the disease were studied. The results of treatment of patients who received and who did not receive methotrexate were studied (standard therapy — non-steroidal anti-inflammatory drugs and intra-articular injections of glucocorticoids). The established cases of uveitis were taken into account.Results: The study analyzed the results of observation of 281 children with JIA. In the methotrexate group, uveitis was detected in 22/191 (11.5%), and in the control group — in 42/90 (46.7%) of patients (OR 6.7; 95% CI 3.7–12.3). The time period between the onset of JIA and development of uveitis in two groups under study was the same and equal to 24 (12; 67) and 17 months (7; 35), respectively (p = 0.232). Multivariate regression analysis showed that the main predictors of uveitis were oligoarticular course of JIA (HR = 1.89), positive antinuclear antibody test (HR = 2.14), onset of JIA under the age of 5 (HR = 2.56), female gender (HR = 1.82),and the absence of methotrexate in the therapy (HR = 0.24).Conclusion: The treatment with methotrexate may reduce the risk of uveitis in patients with JIA. To confirm this hypothesis, randomized studies are needed. |
| first_indexed | 2024-03-12T04:22:11Z |
| format | Article |
| id | doaj.art-9bc2729b6f294ef38331519246db5ed7 |
| institution | Directory Open Access Journal |
| issn | 1682-5527 1682-5535 |
| language | English |
| last_indexed | 2024-03-12T04:22:11Z |
| publishDate | 2015-09-01 |
| publisher | "Paediatrician" Publishers LLC |
| record_format | Article |
| series | Вопросы современной педиатрии |
| spelling | doaj.art-9bc2729b6f294ef38331519246db5ed72023-09-03T10:33:02Zeng"Paediatrician" Publishers LLCВопросы современной педиатрии1682-55271682-55352015-09-0114447748210.15690/vsp.v14.i4.13861078Can the Methotrexate Therapy Prevent the Development of Uveitis in Patients with Juvenile Idiopathic Arthritis: Results of a Retrospective StudyM. M. Kostik0E. V. Gaydar1M. F. Dubko2V. V. Masalova3L. S. Snegireva4I. A. Chikova5E. A. Isupova6T. N. Nikitina7E. D. Serogodskaya8O. V. Kalashnikova9A. Ravelli10V. G. Chasnyk11Санкт-Петербургский государственный педиатрический медицинский университет, Санкт-Петербург, Российская ФедерацияСанкт-Петербургский государственный педиатрический медицинский университет, Санкт-Петербург, Российская ФедерацияСанкт-Петербургский государственный педиатрический медицинский университет, Санкт-Петербург, Российская ФедерацияСанкт-Петербургский государственный педиатрический медицинский университет, Санкт-Петербург, Российская ФедерацияСанкт-Петербургский государственный педиатрический медицинский университет, Санкт-Петербург, Российская ФедерацияСанкт-Петербургский государственный педиатрический медицинский университет, Санкт-Петербург, Российская ФедерацияСанкт-Петербургский государственный педиатрический медицинский университет, Санкт-Петербург, Российская ФедерацияСанкт-Петербургский государственный педиатрический медицинский университет, Санкт-Петербург, Российская ФедерацияСанкт-Петербургский государственный педиатрический медицинский университет, Санкт-Петербург, Российская ФедерацияСанкт-Петербургский государственный педиатрический медицинский университет, Санкт-Петербург, Российская ФедерацияИнститут Г. Газлини, Генуя, Италия Университет Генуи, Генуя, ИталияСанкт-Петербургский государственный педиатрический медицинский университет, Санкт-Петербург, Российская ФедерацияBackground: Uveitis is one of the most common extra-articular manifestations of juvenile idiopathic arthritis (JIA). Currently, the possibility of reducing the risk of uveitis in children with JIA by using methotrexate has been studied.Objective: Our aim was to analyze the results of treatment of children with JIA by studying the relation between the use of methotrexate and the risk of uveitis.Methods: A retrospective uncontrolled study. The case histories of patients with JIA who were treated for at least 2 years after the onset of the disease were studied. The results of treatment of patients who received and who did not receive methotrexate were studied (standard therapy — non-steroidal anti-inflammatory drugs and intra-articular injections of glucocorticoids). The established cases of uveitis were taken into account.Results: The study analyzed the results of observation of 281 children with JIA. In the methotrexate group, uveitis was detected in 22/191 (11.5%), and in the control group — in 42/90 (46.7%) of patients (OR 6.7; 95% CI 3.7–12.3). The time period between the onset of JIA and development of uveitis in two groups under study was the same and equal to 24 (12; 67) and 17 months (7; 35), respectively (p = 0.232). Multivariate regression analysis showed that the main predictors of uveitis were oligoarticular course of JIA (HR = 1.89), positive antinuclear antibody test (HR = 2.14), onset of JIA under the age of 5 (HR = 2.56), female gender (HR = 1.82),and the absence of methotrexate in the therapy (HR = 0.24).Conclusion: The treatment with methotrexate may reduce the risk of uveitis in patients with JIA. To confirm this hypothesis, randomized studies are needed.https://vsp.spr-journal.ru/jour/article/view/1077детиювенильный идиопатический артритувеитрискметотрексат |
| spellingShingle | M. M. Kostik E. V. Gaydar M. F. Dubko V. V. Masalova L. S. Snegireva I. A. Chikova E. A. Isupova T. N. Nikitina E. D. Serogodskaya O. V. Kalashnikova A. Ravelli V. G. Chasnyk Can the Methotrexate Therapy Prevent the Development of Uveitis in Patients with Juvenile Idiopathic Arthritis: Results of a Retrospective Study Вопросы современной педиатрии дети ювенильный идиопатический артрит увеит риск метотрексат |
| title | Can the Methotrexate Therapy Prevent the Development of Uveitis in Patients with Juvenile Idiopathic Arthritis: Results of a Retrospective Study |
| title_full | Can the Methotrexate Therapy Prevent the Development of Uveitis in Patients with Juvenile Idiopathic Arthritis: Results of a Retrospective Study |
| title_fullStr | Can the Methotrexate Therapy Prevent the Development of Uveitis in Patients with Juvenile Idiopathic Arthritis: Results of a Retrospective Study |
| title_full_unstemmed | Can the Methotrexate Therapy Prevent the Development of Uveitis in Patients with Juvenile Idiopathic Arthritis: Results of a Retrospective Study |
| title_short | Can the Methotrexate Therapy Prevent the Development of Uveitis in Patients with Juvenile Idiopathic Arthritis: Results of a Retrospective Study |
| title_sort | can the methotrexate therapy prevent the development of uveitis in patients with juvenile idiopathic arthritis results of a retrospective study |
| topic | дети ювенильный идиопатический артрит увеит риск метотрексат |
| url | https://vsp.spr-journal.ru/jour/article/view/1077 |
| work_keys_str_mv | AT mmkostik canthemethotrexatetherapypreventthedevelopmentofuveitisinpatientswithjuvenileidiopathicarthritisresultsofaretrospectivestudy AT evgaydar canthemethotrexatetherapypreventthedevelopmentofuveitisinpatientswithjuvenileidiopathicarthritisresultsofaretrospectivestudy AT mfdubko canthemethotrexatetherapypreventthedevelopmentofuveitisinpatientswithjuvenileidiopathicarthritisresultsofaretrospectivestudy AT vvmasalova canthemethotrexatetherapypreventthedevelopmentofuveitisinpatientswithjuvenileidiopathicarthritisresultsofaretrospectivestudy AT lssnegireva canthemethotrexatetherapypreventthedevelopmentofuveitisinpatientswithjuvenileidiopathicarthritisresultsofaretrospectivestudy AT iachikova canthemethotrexatetherapypreventthedevelopmentofuveitisinpatientswithjuvenileidiopathicarthritisresultsofaretrospectivestudy AT eaisupova canthemethotrexatetherapypreventthedevelopmentofuveitisinpatientswithjuvenileidiopathicarthritisresultsofaretrospectivestudy AT tnnikitina canthemethotrexatetherapypreventthedevelopmentofuveitisinpatientswithjuvenileidiopathicarthritisresultsofaretrospectivestudy AT edserogodskaya canthemethotrexatetherapypreventthedevelopmentofuveitisinpatientswithjuvenileidiopathicarthritisresultsofaretrospectivestudy AT ovkalashnikova canthemethotrexatetherapypreventthedevelopmentofuveitisinpatientswithjuvenileidiopathicarthritisresultsofaretrospectivestudy AT aravelli canthemethotrexatetherapypreventthedevelopmentofuveitisinpatientswithjuvenileidiopathicarthritisresultsofaretrospectivestudy AT vgchasnyk canthemethotrexatetherapypreventthedevelopmentofuveitisinpatientswithjuvenileidiopathicarthritisresultsofaretrospectivestudy |