Thrombotic Risk and Calculated Whole Blood Viscosity in a Cohort of Patients With New Diagnosis of Multiple Myeloma
The pathogenesis of venous thromboembolism in multiple myeloma is still poorly understood because multiple factors are involved. In particular, the increase in whole blood viscosity has a key role and, therefore, we performed an evaluation of some hemorheological determinants in multiple myeloma pat...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2024-01-01
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| Series: | Clinical and Applied Thrombosis/Hemostasis |
| Online Access: | https://doi.org/10.1177/10760296231222477 |
| _version_ | 1797366074082066432 |
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| author | Melania Carlisi MD Rosalia Lo Presti MD Salvatrice Mancuso MD Sergio Siragusa MD Gregorio Caimi MD |
| author_facet | Melania Carlisi MD Rosalia Lo Presti MD Salvatrice Mancuso MD Sergio Siragusa MD Gregorio Caimi MD |
| author_sort | Melania Carlisi MD |
| collection | DOAJ |
| description | The pathogenesis of venous thromboembolism in multiple myeloma is still poorly understood because multiple factors are involved. In particular, the increase in whole blood viscosity has a key role and, therefore, we performed an evaluation of some hemorheological determinants in multiple myeloma patients, putting them in relation to the thrombotic risk, with the aim to evaluate if an alteration of the hemorheological pattern was associated with a higher thrombotic risk. We performed an observational retrospective cohort study with data collected from January 2017 to September 2022. In a group of 190 patients with newly diagnosed multiple myeloma, we have examined the trend of calculated blood viscosity according to the Merrill formula, and we stratified the patients for the thrombotic risk in accordance with the IMWG/NCCN guidelines and with IMPEDE VTE score. Using the thrombotic risk stratification proposed by IMWG/NCCN any variation in calculated blood viscosity is evident, while, with the IMPEDE VTE score, we observed an increase in calculated blood viscosity in patients with “intermediate + high” risk. The calculated blood viscosity is higher in subjects presenting an “intermediate + high” thrombotic risk according to the IMPEDE VTE score. This association could therefore lay the groundwork for further research with the aim to confirm the role of hemorheological pattern in MM-related thrombotic risk. |
| first_indexed | 2024-03-08T16:59:02Z |
| format | Article |
| id | doaj.art-9bc4da46647645a995b2b1a484f95881 |
| institution | Directory Open Access Journal |
| issn | 1938-2723 |
| language | English |
| last_indexed | 2024-03-08T16:59:02Z |
| publishDate | 2024-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Clinical and Applied Thrombosis/Hemostasis |
| spelling | doaj.art-9bc4da46647645a995b2b1a484f958812024-01-04T16:08:39ZengSAGE PublishingClinical and Applied Thrombosis/Hemostasis1938-27232024-01-013010.1177/10760296231222477Thrombotic Risk and Calculated Whole Blood Viscosity in a Cohort of Patients With New Diagnosis of Multiple MyelomaMelania Carlisi MD0Rosalia Lo Presti MD1Salvatrice Mancuso MD2Sergio Siragusa MD3Gregorio Caimi MD4 Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, , Palermo, Italy Department of Psychology, Educational Science and Human Movement, , Palermo, Italy Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, , Palermo, Italy Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, , Palermo, Italy Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, , Palermo, ItalyThe pathogenesis of venous thromboembolism in multiple myeloma is still poorly understood because multiple factors are involved. In particular, the increase in whole blood viscosity has a key role and, therefore, we performed an evaluation of some hemorheological determinants in multiple myeloma patients, putting them in relation to the thrombotic risk, with the aim to evaluate if an alteration of the hemorheological pattern was associated with a higher thrombotic risk. We performed an observational retrospective cohort study with data collected from January 2017 to September 2022. In a group of 190 patients with newly diagnosed multiple myeloma, we have examined the trend of calculated blood viscosity according to the Merrill formula, and we stratified the patients for the thrombotic risk in accordance with the IMWG/NCCN guidelines and with IMPEDE VTE score. Using the thrombotic risk stratification proposed by IMWG/NCCN any variation in calculated blood viscosity is evident, while, with the IMPEDE VTE score, we observed an increase in calculated blood viscosity in patients with “intermediate + high” risk. The calculated blood viscosity is higher in subjects presenting an “intermediate + high” thrombotic risk according to the IMPEDE VTE score. This association could therefore lay the groundwork for further research with the aim to confirm the role of hemorheological pattern in MM-related thrombotic risk.https://doi.org/10.1177/10760296231222477 |
| spellingShingle | Melania Carlisi MD Rosalia Lo Presti MD Salvatrice Mancuso MD Sergio Siragusa MD Gregorio Caimi MD Thrombotic Risk and Calculated Whole Blood Viscosity in a Cohort of Patients With New Diagnosis of Multiple Myeloma Clinical and Applied Thrombosis/Hemostasis |
| title | Thrombotic Risk and Calculated Whole Blood Viscosity in a Cohort of Patients With New Diagnosis of Multiple Myeloma |
| title_full | Thrombotic Risk and Calculated Whole Blood Viscosity in a Cohort of Patients With New Diagnosis of Multiple Myeloma |
| title_fullStr | Thrombotic Risk and Calculated Whole Blood Viscosity in a Cohort of Patients With New Diagnosis of Multiple Myeloma |
| title_full_unstemmed | Thrombotic Risk and Calculated Whole Blood Viscosity in a Cohort of Patients With New Diagnosis of Multiple Myeloma |
| title_short | Thrombotic Risk and Calculated Whole Blood Viscosity in a Cohort of Patients With New Diagnosis of Multiple Myeloma |
| title_sort | thrombotic risk and calculated whole blood viscosity in a cohort of patients with new diagnosis of multiple myeloma |
| url | https://doi.org/10.1177/10760296231222477 |
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