Risk to human and animal health related to the presence of 4,15‐diacetoxyscirpenol in food and feed
Abstract 4,15‐Diacetoxyscirpenol (DAS) is a mycotoxin primarily produced by Fusarium fungi and occurring predominantly in cereal grains. As requested by the European Commission, the EFSA Panel on Contaminants in the Food Chain (CONTAM) assessed the risk of DAS to human and animal health related to i...
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| Format: | Article |
| Language: | English |
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Wiley
2018-08-01
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| Series: | EFSA Journal |
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| Online Access: | https://doi.org/10.2903/j.efsa.2018.5367 |
| _version_ | 1818735822739865600 |
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| author | EFSA Panel on Contaminants in the Food Chain (CONTAM) Helle Katrine Knutsen Jan Alexander Lars Barregård Margherita Bignami Beat Brüschweiler Sandra Ceccatelli Bruce Cottrill Michael Dinovi Bettina Grasl‐Kraupp Christer Hogstrand Laurentius (Ron) Hoogenboom Carlo Stefano Nebbia Isabelle P Oswald Annette Petersen Martin Rose Alain‐Claude Roudot Tanja Schwerdtle Christiane Vleminckx Günter Vollmer Heather Wallace Sarah De Saeger Gunnar Sundstøl Eriksen Peter Farmer Jean‐Marc Fremy Yun Yun Gong Karsten Meyer Dominique Parent‐Massin Hans van Egmond Andrea Altieri Paolo Colombo Zsuzsanna Horváth Sara Levorato Lutz Edler |
| author_facet | EFSA Panel on Contaminants in the Food Chain (CONTAM) Helle Katrine Knutsen Jan Alexander Lars Barregård Margherita Bignami Beat Brüschweiler Sandra Ceccatelli Bruce Cottrill Michael Dinovi Bettina Grasl‐Kraupp Christer Hogstrand Laurentius (Ron) Hoogenboom Carlo Stefano Nebbia Isabelle P Oswald Annette Petersen Martin Rose Alain‐Claude Roudot Tanja Schwerdtle Christiane Vleminckx Günter Vollmer Heather Wallace Sarah De Saeger Gunnar Sundstøl Eriksen Peter Farmer Jean‐Marc Fremy Yun Yun Gong Karsten Meyer Dominique Parent‐Massin Hans van Egmond Andrea Altieri Paolo Colombo Zsuzsanna Horváth Sara Levorato Lutz Edler |
| author_sort | EFSA Panel on Contaminants in the Food Chain (CONTAM) |
| collection | DOAJ |
| description | Abstract 4,15‐Diacetoxyscirpenol (DAS) is a mycotoxin primarily produced by Fusarium fungi and occurring predominantly in cereal grains. As requested by the European Commission, the EFSA Panel on Contaminants in the Food Chain (CONTAM) assessed the risk of DAS to human and animal health related to its presence in food and feed. Very limited information was available on toxicity and on toxicokinetics in experimental and farm animals. Due to the limitations in the available data set, human acute and chronic health‐based guidance values (HBGV) were established based on data obtained in clinical trials of DAS as an anticancer agent (anguidine) after intravenous administration to cancer patients. The CONTAM Panel considered these data as informative for the hazard characterisation of DAS after oral exposure. The main adverse effects after acute and repeated exposure were emesis, with a no‐observed‐adverse‐effect level (NOAEL) of 32 μg DAS/kg body weight (bw), and haematotoxicity, with a NOAEL of 65 μg DAS/kg bw, respectively. An acute reference dose (ARfD) of 3.2 μg DAS/kg bw and a tolerable daily intake (TDI) of 0.65 μg DAS/kg bw were established. Based on over 15,000 occurrence data, the highest acute and chronic dietary exposures were estimated to be 0.8 and 0.49 μg DAS/kg bw per day, respectively, and were not of health concern for humans. The limited information for poultry, pigs and dogs indicated a low risk for these animals at the estimated DAS exposure levels under current feeding practices, with the possible exception of fattening chicken. Assuming similar or lower sensitivity than for poultry, the risk was considered overall low for other farm and companion animal species for which no toxicity data were available. In consideration of the similarities of several trichothecenes and the likelihood of co‐exposure via food and feed, it could be appropriate to perform a cumulative risk assessment for this group of substances. |
| first_indexed | 2024-12-18T00:27:22Z |
| format | Article |
| id | doaj.art-9bc6130470d24728b695a03f35cbfe8a |
| institution | Directory Open Access Journal |
| issn | 1831-4732 |
| language | English |
| last_indexed | 2024-12-18T00:27:22Z |
| publishDate | 2018-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | EFSA Journal |
| spelling | doaj.art-9bc6130470d24728b695a03f35cbfe8a2022-12-21T21:27:13ZengWileyEFSA Journal1831-47322018-08-01168n/an/a10.2903/j.efsa.2018.5367Risk to human and animal health related to the presence of 4,15‐diacetoxyscirpenol in food and feedEFSA Panel on Contaminants in the Food Chain (CONTAM)Helle Katrine KnutsenJan AlexanderLars BarregårdMargherita BignamiBeat BrüschweilerSandra CeccatelliBruce CottrillMichael DinoviBettina Grasl‐KrauppChrister HogstrandLaurentius (Ron) HoogenboomCarlo Stefano NebbiaIsabelle P OswaldAnnette PetersenMartin RoseAlain‐Claude RoudotTanja SchwerdtleChristiane VleminckxGünter VollmerHeather WallaceSarah De SaegerGunnar Sundstøl EriksenPeter FarmerJean‐Marc FremyYun Yun GongKarsten MeyerDominique Parent‐MassinHans van EgmondAndrea AltieriPaolo ColomboZsuzsanna HorváthSara LevoratoLutz EdlerAbstract 4,15‐Diacetoxyscirpenol (DAS) is a mycotoxin primarily produced by Fusarium fungi and occurring predominantly in cereal grains. As requested by the European Commission, the EFSA Panel on Contaminants in the Food Chain (CONTAM) assessed the risk of DAS to human and animal health related to its presence in food and feed. Very limited information was available on toxicity and on toxicokinetics in experimental and farm animals. Due to the limitations in the available data set, human acute and chronic health‐based guidance values (HBGV) were established based on data obtained in clinical trials of DAS as an anticancer agent (anguidine) after intravenous administration to cancer patients. The CONTAM Panel considered these data as informative for the hazard characterisation of DAS after oral exposure. The main adverse effects after acute and repeated exposure were emesis, with a no‐observed‐adverse‐effect level (NOAEL) of 32 μg DAS/kg body weight (bw), and haematotoxicity, with a NOAEL of 65 μg DAS/kg bw, respectively. An acute reference dose (ARfD) of 3.2 μg DAS/kg bw and a tolerable daily intake (TDI) of 0.65 μg DAS/kg bw were established. Based on over 15,000 occurrence data, the highest acute and chronic dietary exposures were estimated to be 0.8 and 0.49 μg DAS/kg bw per day, respectively, and were not of health concern for humans. The limited information for poultry, pigs and dogs indicated a low risk for these animals at the estimated DAS exposure levels under current feeding practices, with the possible exception of fattening chicken. Assuming similar or lower sensitivity than for poultry, the risk was considered overall low for other farm and companion animal species for which no toxicity data were available. In consideration of the similarities of several trichothecenes and the likelihood of co‐exposure via food and feed, it could be appropriate to perform a cumulative risk assessment for this group of substances.https://doi.org/10.2903/j.efsa.2018.53674,15 ‐ diacetoxyscirpenolDASanguidineMASexposuretoxicity |
| spellingShingle | EFSA Panel on Contaminants in the Food Chain (CONTAM) Helle Katrine Knutsen Jan Alexander Lars Barregård Margherita Bignami Beat Brüschweiler Sandra Ceccatelli Bruce Cottrill Michael Dinovi Bettina Grasl‐Kraupp Christer Hogstrand Laurentius (Ron) Hoogenboom Carlo Stefano Nebbia Isabelle P Oswald Annette Petersen Martin Rose Alain‐Claude Roudot Tanja Schwerdtle Christiane Vleminckx Günter Vollmer Heather Wallace Sarah De Saeger Gunnar Sundstøl Eriksen Peter Farmer Jean‐Marc Fremy Yun Yun Gong Karsten Meyer Dominique Parent‐Massin Hans van Egmond Andrea Altieri Paolo Colombo Zsuzsanna Horváth Sara Levorato Lutz Edler Risk to human and animal health related to the presence of 4,15‐diacetoxyscirpenol in food and feed EFSA Journal 4,15 ‐ diacetoxyscirpenol DAS anguidine MAS exposure toxicity |
| title | Risk to human and animal health related to the presence of 4,15‐diacetoxyscirpenol in food and feed |
| title_full | Risk to human and animal health related to the presence of 4,15‐diacetoxyscirpenol in food and feed |
| title_fullStr | Risk to human and animal health related to the presence of 4,15‐diacetoxyscirpenol in food and feed |
| title_full_unstemmed | Risk to human and animal health related to the presence of 4,15‐diacetoxyscirpenol in food and feed |
| title_short | Risk to human and animal health related to the presence of 4,15‐diacetoxyscirpenol in food and feed |
| title_sort | risk to human and animal health related to the presence of 4 15 diacetoxyscirpenol in food and feed |
| topic | 4,15 ‐ diacetoxyscirpenol DAS anguidine MAS exposure toxicity |
| url | https://doi.org/10.2903/j.efsa.2018.5367 |
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