Alpha-Synuclein Expression in Acute Erythroleukaemia, Acute Megakaryoblastic Leukemia, and Normal Counterparts in Bone Marrow
Background:Alpha-synuclein is a member of synuclein family of proteins with unidentified function localized in the cytoplasm, mitochondria of neurons, and presynaptic nerve endings. Although it is found in the Lewy bodies in synucleinopathies and in Alzheimer’s disease, the protein could also be con...
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| Format: | Article |
| Language: | English |
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Iranian Society of Pathology
2017-01-01
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| Series: | Iranian Journal of Pathology |
| Subjects: | |
| Online Access: | https://ijp.iranpath.org/article_24230_0c2a4528d3d0e59b9d10962f8a2f59ee.pdf |
| _version_ | 1819096930105425920 |
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| author | Farid Kosari Sanam Akbarzadeh Hiva Saffar |
| author_facet | Farid Kosari Sanam Akbarzadeh Hiva Saffar |
| author_sort | Farid Kosari |
| collection | DOAJ |
| description | Background:Alpha-synuclein is a member of synuclein family of proteins with unidentified function localized in the cytoplasm, mitochondria of neurons, and presynaptic nerve endings. Although it is found in the Lewy bodies in synucleinopathies and in Alzheimer’s disease, the protein could also be considered as a novel marker in diagnosis of diseases related to the hematopoietic system.
Methods: The current study evaluated alpha-synuclein expression in bone marrow sections obtained from 9 patients with acute myeloblastic leukemia (AML)-M6, 2 patients with AML-M7, and 56 patients with other forms of AML by immunohistochemical (IHC) analysis Results: Seven out of 9 cases with erythroleukemia (66.7%) and 1 of the 2 cases with M7 (50%) were positive. In contrast; the blasts in 2 out of 56 AML cases with non-M6/M7 (3.6%) showed positive staining. Accordingly, alpha-synuclein was positive in normal erythroid precursors and megakaryocytes (if existing) in these cases; while, it was negative in lymphoid and myeloid precursors. Conclusion: Alpha-synuclein expression in non-neoplastic and neoplastic erythroid cells and megakaryocytes could be used as a complementary and useful marker for distinction between AML-M6/M7 and other types of AML |
| first_indexed | 2024-12-22T00:07:01Z |
| format | Article |
| id | doaj.art-9bc80c31cf084ce6a3dfd3d878b340d5 |
| institution | Directory Open Access Journal |
| issn | 1735-5303 2345-3656 |
| language | English |
| last_indexed | 2024-12-22T00:07:01Z |
| publishDate | 2017-01-01 |
| publisher | Iranian Society of Pathology |
| record_format | Article |
| series | Iranian Journal of Pathology |
| spelling | doaj.art-9bc80c31cf084ce6a3dfd3d878b340d52022-12-21T18:45:32ZengIranian Society of PathologyIranian Journal of Pathology1735-53032345-36562017-01-01121747810.30699/ijp.2017.2423024230Alpha-Synuclein Expression in Acute Erythroleukaemia, Acute Megakaryoblastic Leukemia, and Normal Counterparts in Bone MarrowFarid Kosari0Sanam Akbarzadeh1Hiva Saffar2Dept. of Pathology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, IranDept. of Pathology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, IranDept. of Pathology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, IranBackground:Alpha-synuclein is a member of synuclein family of proteins with unidentified function localized in the cytoplasm, mitochondria of neurons, and presynaptic nerve endings. Although it is found in the Lewy bodies in synucleinopathies and in Alzheimer’s disease, the protein could also be considered as a novel marker in diagnosis of diseases related to the hematopoietic system. Methods: The current study evaluated alpha-synuclein expression in bone marrow sections obtained from 9 patients with acute myeloblastic leukemia (AML)-M6, 2 patients with AML-M7, and 56 patients with other forms of AML by immunohistochemical (IHC) analysis Results: Seven out of 9 cases with erythroleukemia (66.7%) and 1 of the 2 cases with M7 (50%) were positive. In contrast; the blasts in 2 out of 56 AML cases with non-M6/M7 (3.6%) showed positive staining. Accordingly, alpha-synuclein was positive in normal erythroid precursors and megakaryocytes (if existing) in these cases; while, it was negative in lymphoid and myeloid precursors. Conclusion: Alpha-synuclein expression in non-neoplastic and neoplastic erythroid cells and megakaryocytes could be used as a complementary and useful marker for distinction between AML-M6/M7 and other types of AMLhttps://ijp.iranpath.org/article_24230_0c2a4528d3d0e59b9d10962f8a2f59ee.pdfacute myeloblastic leukemiaaml m6aml m7α- synuclein |
| spellingShingle | Farid Kosari Sanam Akbarzadeh Hiva Saffar Alpha-Synuclein Expression in Acute Erythroleukaemia, Acute Megakaryoblastic Leukemia, and Normal Counterparts in Bone Marrow Iranian Journal of Pathology acute myeloblastic leukemia aml m6 aml m7 α- synuclein |
| title | Alpha-Synuclein Expression in Acute Erythroleukaemia, Acute Megakaryoblastic Leukemia, and Normal Counterparts in Bone Marrow |
| title_full | Alpha-Synuclein Expression in Acute Erythroleukaemia, Acute Megakaryoblastic Leukemia, and Normal Counterparts in Bone Marrow |
| title_fullStr | Alpha-Synuclein Expression in Acute Erythroleukaemia, Acute Megakaryoblastic Leukemia, and Normal Counterparts in Bone Marrow |
| title_full_unstemmed | Alpha-Synuclein Expression in Acute Erythroleukaemia, Acute Megakaryoblastic Leukemia, and Normal Counterparts in Bone Marrow |
| title_short | Alpha-Synuclein Expression in Acute Erythroleukaemia, Acute Megakaryoblastic Leukemia, and Normal Counterparts in Bone Marrow |
| title_sort | alpha synuclein expression in acute erythroleukaemia acute megakaryoblastic leukemia and normal counterparts in bone marrow |
| topic | acute myeloblastic leukemia aml m6 aml m7 α- synuclein |
| url | https://ijp.iranpath.org/article_24230_0c2a4528d3d0e59b9d10962f8a2f59ee.pdf |
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