Primary Synovial Sarcoma of the Thyroid Gland: Case Report and Review of the Literature
Synovial sarcoma (SVS) of the thyroid gland is exceedingly rare. We report the case of a 55-year-old man with a rapidly growing 7-cm neck mass. Because of suspicion of anaplastic thyroid carcinoma, a total thyroidectomy was planned, without preoperative cytology. During surgery, the tumor ruptured,...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Karger Publishers
2014-01-01
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| Series: | Case Reports in Oncology |
| Subjects: | |
| Online Access: | http://www.karger.com/Article/FullText/357913 |
| _version_ | 1819072363193434112 |
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| author | Laurys Boudin Nicolas Fakhry Bruno Chetaille Delphine Perrot Anh Tuan Nguyen Nassima Daidj Jérôme Guiramand Anthony Sarran Laurence Moureau-Zabotto François Bertucci |
| author_facet | Laurys Boudin Nicolas Fakhry Bruno Chetaille Delphine Perrot Anh Tuan Nguyen Nassima Daidj Jérôme Guiramand Anthony Sarran Laurence Moureau-Zabotto François Bertucci |
| author_sort | Laurys Boudin |
| collection | DOAJ |
| description | Synovial sarcoma (SVS) of the thyroid gland is exceedingly rare. We report the case of a 55-year-old man with a rapidly growing 7-cm neck mass. Because of suspicion of anaplastic thyroid carcinoma, a total thyroidectomy was planned, without preoperative cytology. During surgery, the tumor ruptured, leading to fragmented and incomplete resection. The morphological and immunohistochemical aspects suggested thyroid SVS, which was confirmed by fluorescent in situ hybridization (SYT gene rearrangement). The patient experienced immediate local relapse in close contact with large vessels and the thyroid cartilage and was referred to our institution. Doxorubicin-ifosfamide chemotherapy led to a minor response that authorized secondary conservative surgery. Because of microscopically incomplete resection, adjuvant radiotherapy was chosen and is ongoing 10 months after initial surgery. The prognosis of thyroid SVS is associated with a high risk for local and metastatic relapses. Pretreatment diagnosis is fundamental and may benefit from molecular analysis. Margin-free monobloc surgical excision is the best chance for cure, but adjuvant chemotherapy and radiotherapy deserve to be discussed. |
| first_indexed | 2024-12-21T17:36:32Z |
| format | Article |
| id | doaj.art-9bc822ce03f343c2956fed26f7b605b4 |
| institution | Directory Open Access Journal |
| issn | 1662-6575 |
| language | English |
| last_indexed | 2024-12-21T17:36:32Z |
| publishDate | 2014-01-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Oncology |
| spelling | doaj.art-9bc822ce03f343c2956fed26f7b605b42022-12-21T18:55:45ZengKarger PublishersCase Reports in Oncology1662-65752014-01-017161310.1159/000357913357913Primary Synovial Sarcoma of the Thyroid Gland: Case Report and Review of the LiteratureLaurys BoudinNicolas FakhryBruno ChetailleDelphine PerrotAnh Tuan NguyenNassima DaidjJérôme GuiramandAnthony SarranLaurence Moureau-ZabottoFrançois BertucciSynovial sarcoma (SVS) of the thyroid gland is exceedingly rare. We report the case of a 55-year-old man with a rapidly growing 7-cm neck mass. Because of suspicion of anaplastic thyroid carcinoma, a total thyroidectomy was planned, without preoperative cytology. During surgery, the tumor ruptured, leading to fragmented and incomplete resection. The morphological and immunohistochemical aspects suggested thyroid SVS, which was confirmed by fluorescent in situ hybridization (SYT gene rearrangement). The patient experienced immediate local relapse in close contact with large vessels and the thyroid cartilage and was referred to our institution. Doxorubicin-ifosfamide chemotherapy led to a minor response that authorized secondary conservative surgery. Because of microscopically incomplete resection, adjuvant radiotherapy was chosen and is ongoing 10 months after initial surgery. The prognosis of thyroid SVS is associated with a high risk for local and metastatic relapses. Pretreatment diagnosis is fundamental and may benefit from molecular analysis. Margin-free monobloc surgical excision is the best chance for cure, but adjuvant chemotherapy and radiotherapy deserve to be discussed.http://www.karger.com/Article/FullText/357913Primary synovial sarcomaThyroid glandChemotherapyPrognosis |
| spellingShingle | Laurys Boudin Nicolas Fakhry Bruno Chetaille Delphine Perrot Anh Tuan Nguyen Nassima Daidj Jérôme Guiramand Anthony Sarran Laurence Moureau-Zabotto François Bertucci Primary Synovial Sarcoma of the Thyroid Gland: Case Report and Review of the Literature Case Reports in Oncology Primary synovial sarcoma Thyroid gland Chemotherapy Prognosis |
| title | Primary Synovial Sarcoma of the Thyroid Gland: Case Report and Review of the Literature |
| title_full | Primary Synovial Sarcoma of the Thyroid Gland: Case Report and Review of the Literature |
| title_fullStr | Primary Synovial Sarcoma of the Thyroid Gland: Case Report and Review of the Literature |
| title_full_unstemmed | Primary Synovial Sarcoma of the Thyroid Gland: Case Report and Review of the Literature |
| title_short | Primary Synovial Sarcoma of the Thyroid Gland: Case Report and Review of the Literature |
| title_sort | primary synovial sarcoma of the thyroid gland case report and review of the literature |
| topic | Primary synovial sarcoma Thyroid gland Chemotherapy Prognosis |
| url | http://www.karger.com/Article/FullText/357913 |
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