Regulation of the renin-angiotensin-aldosterone system by cyclic nucleotides and phosphodiesterases
The renin-angiotensin-aldosterone system (RAAS) is one of the key players in the regulation of blood volume and blood pressure. Dysfunction of this system is connected with cardiovascular and renal diseases. Regulation of RAAS is under the control of multiple intracellular mechanisms. Cyclic nucleot...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-08-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1239492/full |
| _version_ | 1797739334751748096 |
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| author | Stepan Gambaryan Sanika Mohagaonkar Sanika Mohagaonkar Viacheslav O. Nikolaev Viacheslav O. Nikolaev |
| author_facet | Stepan Gambaryan Sanika Mohagaonkar Sanika Mohagaonkar Viacheslav O. Nikolaev Viacheslav O. Nikolaev |
| author_sort | Stepan Gambaryan |
| collection | DOAJ |
| description | The renin-angiotensin-aldosterone system (RAAS) is one of the key players in the regulation of blood volume and blood pressure. Dysfunction of this system is connected with cardiovascular and renal diseases. Regulation of RAAS is under the control of multiple intracellular mechanisms. Cyclic nucleotides and phosphodiesterases are the major regulators of this system since they control expression and activity of renin and aldosterone. In this review, we summarize known mechanisms by which cyclic nucleotides and phosphodiesterases regulate renin gene expression, secretion of renin granules from juxtaglomerular cells and aldosterone production from zona glomerulosa cells of adrenal gland. We also discuss several open questions which deserve future attention. |
| first_indexed | 2024-03-12T13:57:02Z |
| format | Article |
| id | doaj.art-9bc8281ddd9c45c4a4471cd711cedeb1 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-12T13:57:02Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-9bc8281ddd9c45c4a4471cd711cedeb12023-08-22T14:00:12ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-08-011410.3389/fendo.2023.12394921239492Regulation of the renin-angiotensin-aldosterone system by cyclic nucleotides and phosphodiesterasesStepan Gambaryan0Sanika Mohagaonkar1Sanika Mohagaonkar2Viacheslav O. Nikolaev3Viacheslav O. Nikolaev4Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, Saint Petersburg, RussiaInstitute of Experimental Cardiovascular Research, University Medical Center Hamburg-Eppendorf, Hamburg, GermanyGerman Center for Cardiovascular Research (DZHK), partner site Hamburg/Kiel/Lübeck, Hamburg, GermanyInstitute of Experimental Cardiovascular Research, University Medical Center Hamburg-Eppendorf, Hamburg, GermanyGerman Center for Cardiovascular Research (DZHK), partner site Hamburg/Kiel/Lübeck, Hamburg, GermanyThe renin-angiotensin-aldosterone system (RAAS) is one of the key players in the regulation of blood volume and blood pressure. Dysfunction of this system is connected with cardiovascular and renal diseases. Regulation of RAAS is under the control of multiple intracellular mechanisms. Cyclic nucleotides and phosphodiesterases are the major regulators of this system since they control expression and activity of renin and aldosterone. In this review, we summarize known mechanisms by which cyclic nucleotides and phosphodiesterases regulate renin gene expression, secretion of renin granules from juxtaglomerular cells and aldosterone production from zona glomerulosa cells of adrenal gland. We also discuss several open questions which deserve future attention.https://www.frontiersin.org/articles/10.3389/fendo.2023.1239492/fullcAMPcGMPphosphodiesterasereninaldosterone |
| spellingShingle | Stepan Gambaryan Sanika Mohagaonkar Sanika Mohagaonkar Viacheslav O. Nikolaev Viacheslav O. Nikolaev Regulation of the renin-angiotensin-aldosterone system by cyclic nucleotides and phosphodiesterases Frontiers in Endocrinology cAMP cGMP phosphodiesterase renin aldosterone |
| title | Regulation of the renin-angiotensin-aldosterone system by cyclic nucleotides and phosphodiesterases |
| title_full | Regulation of the renin-angiotensin-aldosterone system by cyclic nucleotides and phosphodiesterases |
| title_fullStr | Regulation of the renin-angiotensin-aldosterone system by cyclic nucleotides and phosphodiesterases |
| title_full_unstemmed | Regulation of the renin-angiotensin-aldosterone system by cyclic nucleotides and phosphodiesterases |
| title_short | Regulation of the renin-angiotensin-aldosterone system by cyclic nucleotides and phosphodiesterases |
| title_sort | regulation of the renin angiotensin aldosterone system by cyclic nucleotides and phosphodiesterases |
| topic | cAMP cGMP phosphodiesterase renin aldosterone |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1239492/full |
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